Detecting SARS-CoV-2 at point of care: preliminary data comparing loop-mediated isothermal amplification (LAMP) to polymerase chain reaction (PCR)

Autor: Marc F. Österdahl, Karla A. Lee, Mary Ni Lochlainn, Stuart Wilson, Sam Douthwaite, Rachel Horsfall, Alyce Sheedy, Simon D. Goldenberg, Christopher J. Stanley, Tim D. Spector, Claire J. Steves

Publikováno v: BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-8 (2020)

Abstract Background A cost effective and efficient diagnostic tool for COVID-19 as near to the point of care (PoC) as possible would be a game changer in the current pandemic. We tested reverse transcription loop mediated isothermal amplification (RT

Externí odkaz: https://doaj.org/article/3560d14154544216b8bb1e295d7fb5e5

Cutaneous Melanoma – A Review of Systemic Therapies

Autor: Karla A. Lee, Paul Nathan

Publikováno v: Acta Dermato-Venereologica, Vol 100, Iss 11, p adv00141 (2020)

This decade has brought significantly improved outcomes for patients with advanced melanoma with immunotherapies and targeted treatments offering utility in a variety of settings. In 2020, we can hope for durable long-term responses, and complete rem

Externí odkaz: https://doaj.org/article/ded58a3edaeb419d8de1127dfa0a2e3b

Neratinib in advanced HER2-positive breast cancer: experience from the royal Marsden hospital

Autor: Niamh Cunningham, Scott Shepherd, Kabir Mohammed, Karla A. Lee, Mark Allen, Stephen Johnston, Emma Kipps, Sophie McGrath, Jillian Noble, Marina Parton, Alistair Ring, Nicholas C. Turner, Alicia F. C. Okines

Publikováno v: Breast Cancer Research and Treatment. 195:333-340

To describe the tolerability and efficacy of neratinib as a monotherapy and in combination with capecitabine in advanced HER2-positive breast cancer in a real-world setting.Patients who received neratinib for advanced HER2-positive at the Royal Marsd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70465196bcca7cdac49a85377ff5fad2
https://doi.org/10.1007/s10549-022-06703-3

144 Probable Delirium is A Presenting Symptom of COVID-19 in Frail, Older Adults: A Study of Hospitalised and Community-Based Cohorts

Autor: Amy L. Roberts, Kerrin S. Small, Maxim B. Freidin, Finbarr C. Martin, Claire J. Steves, Carly Welch, Marc Modat, M. Ni Lochlainn, Carole H. Sudre, Rose S. Penfold, Massimo Mangino, J. S. El-Sayed Moustafa, M. B. Zazzara, Alessia Visconti, Benjamin J. Murray, Hannah Dooley, Sebastian Ourselin, Ruth C. E. Bowyer, Karla A. Lee, Jonathan Wolf

Publikováno v: Age and Ageing

Introduction COVID-19 exhibits a more severe disease course in older adults with frailty. Awareness of atypical presentations is critical to facilitate early disease identification. This study aimed to assess how frailty affects presenting symptoms o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dd04198ba517deb7efa3a0dc8921af
https://doi.org/10.1093/ageing/afab030.105

Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma

Autor: Karla A. Lee, Andrew Maltez Thomas, Laura A. Bolte, Johannes R. Björk, Laura Kist de Ruijter, Federica Armanini, Francesco Asnicar, Aitor Blanco-Miguez, Ruth Board, Neus Calbet-Llopart, Lisa Derosa, Nathalie Dhomen, Kelly Brooks, Mark Harland, Mark Harries, Emily R. Leeming, Paul Lorigan, Paolo Manghi, Richard Marais, Julia Newton-Bishop, Luigi Nezi, Federica Pinto, Miriam Potrony, Susana Puig, Patricio Serra-Bellver, Heather M. Shaw, Sabrina Tamburini, Sara Valpione, Amrita Vijay, Levi Waldron, Laurence Zitvogel, Moreno Zolfo, Elisabeth G. E. de Vries, Paul Nathan, Rudolf S. N. Fehrmann, Véronique Bataille, Geke A. P. Hospers, Tim D. Spector, Rinse K. Weersma, Nicola Segata

Publikováno v: Nature Medicine
Lee, K A, Thomas, A M, Bolte, L A, Björk, J R, de Ruijter, L K, Armanini, F, Asnicar, F, Blanco-Miguez, A, Board, R, Calbet-Llopart, N, Derosa, L, Dhomen, N, Brooks, K, Harland, M, Harries, M, Leeming, E R, Lorigan, P, Manghi, P, Marais, R, Newton-Bishop, J, Nezi, L, Pinto, F, Potrony, M, Puig, S, Serra-Bellver, P, Shaw, H M, Tamburini, S, Valpione, S, Vijay, A, Waldron, L, Zitvogel, L, Zolfo, M, de Vries, E G E, Nathan, P, Fehrmann, R S N, Bataille, V, Hospers, G A P, Spector, T D, Weersma, R K & Segata, N 2022, ' Cross-cohort gut microbiome associations with immune checkpoint inhibitor response in advanced melanoma ', Nature Medicine, vol. 28, no. 3, pp. 535-544 . https://doi.org/10.1038/s41591-022-01695-5
Nature Medicine, 28. Nature Publishing Group

The composition of the gut microbiome has been associated with clinical responses to immune checkpoint inhibitor (ICI) treatment, but there is limited consensus on the specific microbiome characteristics linked to the clinical benefits of ICIs. We pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14d9010bfaf4e6f5e7f69e6b0bbaca17