Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Karla A Lee"'
Autor:
Alessia Visconti, Niccolò Rossi, Helena Deriš, Karla A Lee, Maja Hanić, Irena Trbojević-Akmačić, Andrew M. Thomas, Laura A. Bolte, Johannes R. Björk, Jahlisa S. Hooiveld-Noeken, Ruth Board, Mark Harland, Julia Newton-Bishop, Mark Harries, Joseph J. Sacco, Paul Lorigan, Heather M. Shaw, Elisabeth G.E. de Vries, Rudolf S.N. Fehrmann, Rinse K. Weersma, Tim D. Spector, Paul Nathan, Geke A. P. Hospers, Peter Sasieni, Veronique Bataille, Gordan Lauc, Mario Falchi
Publikováno v:
BMC Cancer, Vol 23, Iss 1, Pp 1-12 (2023)
Abstract Background Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of melanoma and other cancers. However, no reliable biomarker of survival or response has entered the clinic to identify those patients with melanoma who are mo
Externí odkaz:
https://doaj.org/article/50b511b7f9af46e6993f096da9d33865
Autor:
Ricardo Costeira, Karla A Lee, Benjamin Murray, Colette Christiansen, Juan Castillo-Fernandez, Mary Ni Lochlainn, Joan Capdevila Pujol, Heather Macfarlane, Louise C Kenny, Iain Buchan, Jonathan Wolf, Janice Rymer, Sebastien Ourselin, Claire J Steves, Timothy D Spector, Louise R Newson, Jordana T Bell
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257051 (2021)
It has been widely observed that adult men of all ages are at higher risk of developing serious complications from COVID-19 when compared with women. This study aimed to investigate the association of COVID-19 positivity and severity with estrogen ex
Externí odkaz:
https://doaj.org/article/80044696924c4141b3a6844546d1683d
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)
Five patients receiving checkpoint inhibitor immunotherapy (CPI) under our care across two cancer centers over a 12-month period have subsequently developed campylobacterosis. All had received immune-suppressive treatment for CPI-related colitis in t
Externí odkaz:
https://doaj.org/article/1395f589ae88473fb361597c0c8e68f4
Autor:
Marc F. Österdahl, Karla A. Lee, Mary Ni Lochlainn, Stuart Wilson, Sam Douthwaite, Rachel Horsfall, Alyce Sheedy, Simon D. Goldenberg, Christopher J. Stanley, Tim D. Spector, Claire J. Steves
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-8 (2020)
Abstract Background A cost effective and efficient diagnostic tool for COVID-19 as near to the point of care (PoC) as possible would be a game changer in the current pandemic. We tested reverse transcription loop mediated isothermal amplification (RT
Externí odkaz:
https://doaj.org/article/3560d14154544216b8bb1e295d7fb5e5
Autor:
Niamh Cunningham, Scott Shepherd, Kabir Mohammed, Karla A. Lee, Mark Allen, Stephen Johnston, Emma Kipps, Sophie McGrath, Jillian Noble, Marina Parton, Alistair Ring, Nicholas C. Turner, Alicia F. C. Okines
Publikováno v:
Breast Cancer Research and Treatment. 195:333-340
To describe the tolerability and efficacy of neratinib as a monotherapy and in combination with capecitabine in advanced HER2-positive breast cancer in a real-world setting.Patients who received neratinib for advanced HER2-positive at the Royal Marsd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70465196bcca7cdac49a85377ff5fad2
https://doi.org/10.1007/s10549-022-06703-3
https://doi.org/10.1007/s10549-022-06703-3
Autor:
Niccolò Rossi, Karla A. Lee, Maria V. Bermudez, Alessia Visconti, Andrew Maltez Thomas, Laura A. Bolte, Johannes R. Björk, Laura Kist de Ruijter, Julia Newton-Bishop, Mark Harland, Heather M. Shaw, Mark Harries, Joseph Sacco, Ruth Board, Paul Lorigan, Elisabeth G.E. de Vries, Nicola Segata, Leonie S. Taams, Sophie Papa, Tim D. Spector, Paul Nathan, Rinse K. Weersma, Geke A.P. Hospers, Rudolf S.N. Fehrmann, Veronique Bataille, Mario Falchi
Publikováno v:
EBioMedicine, 83:104235. ELSEVIER SCIENCE BV
Rossi, N, Lee, K A, Bermudez, M V, Visconti, A, Thomas, A M, Bolte, L A, Björk, J R, de Ruijter, L K, Newton-Bishop, J, Harland, M, Shaw, H M, Harries, M, Sacco, J, Board, R, Lorigan, P, de Vries, E G E, Segata, N, Taams, L, Papa, S, Spector, T D, Nathan, P, Weersma, R K, Hospers, G A P, Fehrmann, R S N, Bataille, V & Falchi, M 2022, ' Circulating inflammatory proteins associate with response to immune checkpoint inhibition therapy in patients with advanced melanoma ', EBioMedicine, vol. 83, 104235 . https://doi.org/10.1016/j.ebiom.2022.104235
Rossi, N, Lee, K A, Bermudez, M V, Visconti, A, Thomas, A M, Bolte, L A, Björk, J R, de Ruijter, L K, Newton-Bishop, J, Harland, M, Shaw, H M, Harries, M, Sacco, J, Board, R, Lorigan, P, de Vries, E G E, Segata, N, Taams, L, Papa, S, Spector, T D, Nathan, P, Weersma, R K, Hospers, G A P, Fehrmann, R S N, Bataille, V & Falchi, M 2022, ' Circulating inflammatory proteins associate with response to immune checkpoint inhibition therapy in patients with advanced melanoma ', EBioMedicine, vol. 83, 104235 . https://doi.org/10.1016/j.ebiom.2022.104235
BACKGROUND: Inflammation can modulate tumour growth and progression, and influence clinical response to treatment. We investigated the potential of circulating inflammatory proteins for response stratification of immune checkpoint inhibitor (ICI) the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b62e91d05782c528505dc9c86b02e7c
https://research.rug.nl/en/publications/cba53c74-4cba-4887-b364-b8661711b46d
https://research.rug.nl/en/publications/cba53c74-4cba-4887-b364-b8661711b46d
Publikováno v:
British Journal of Cancer
The gut microbiome (GM) has been implicated in a vast number of human pathologies and has become a focus of oncology research over the past 5 years. The normal gut microbiota imparts specific function in host nutrient metabolism, xenobiotic and drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d168a332fe613d9eb0363e190439e568
https://doi.org/10.1038/s41416-021-01467-x
https://doi.org/10.1038/s41416-021-01467-x
Autor:
Amy L. Roberts, Kerrin S. Small, Maxim B. Freidin, Finbarr C. Martin, Claire J. Steves, Carly Welch, Marc Modat, M. Ni Lochlainn, Carole H. Sudre, Rose S. Penfold, Massimo Mangino, J. S. El-Sayed Moustafa, M. B. Zazzara, Alessia Visconti, Benjamin J. Murray, Hannah Dooley, Sebastian Ourselin, Ruth C. E. Bowyer, Karla A. Lee, Jonathan Wolf
Publikováno v:
Age and Ageing
Introduction COVID-19 exhibits a more severe disease course in older adults with frailty. Awareness of atypical presentations is critical to facilitate early disease identification. This study aimed to assess how frailty affects presenting symptoms o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9dd04198ba517deb7efa3a0dc8921af
https://doi.org/10.1093/ageing/afab030.105
https://doi.org/10.1093/ageing/afab030.105
Autor:
Laura A. Bolte, Karla A. Lee, Johannes R. Björk, Emily R. Leeming, Marjo J. E. Campmans-Kuijpers, Jacco J. de Haan, Arnau Vich Vila, Andrew Maltez-Thomas, Nicola Segata, Ruth Board, Mark Harries, Paul Lorigan, Elisabeth G. E. de Vries, Paul Nathan, Rudolf Fehrmann, Véronique Bataille, Tim D. Spector, Geke A. P. Hospers, Rinse K. Weersma
Publikováno v:
JAMA Oncology. 9:705
ImportanceImmune checkpoint blockade (ICB) has improved the survival of patients with advanced melanoma. Durable responses are observed for 40% to 60% of patients, depending on treatment regimens. However, there is still large variability in the resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e249d7f0d0240515bbd406ecb2bc6ec
https://doi.org/10.1001/jamaoncol.2022.7753
https://doi.org/10.1001/jamaoncol.2022.7753
Publikováno v:
J Immunother Precis Oncol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10ba04936b4a98351bf0787097f95b5
https://doi.org/10.36401/jipo-20-7
https://doi.org/10.36401/jipo-20-7