Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Karla, Frydenvang"'
Autor:
Karla Frydenvang, Marlies C A Verkade-Vreeker, Floor Dohmen, Jan N M Commandeur, Maria Rafiq, Osman Mirza, Flemming Steen Jørgensen, Daan P Geerke
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0217292 (2019)
The bacterial Cytochrome P450 (CYP) BM3 (CYP102A1) is one of the most active CYP isoforms. BM3 mutants can serve as a model for human drug-metabolizing CYPs and/or as biocatalyst for selective formation of drug metabolites. Hence, molecular and compu
Externí odkaz:
https://doaj.org/article/4ca0b68792244c2ca63e3d37d9ec192e
Autor:
Pippione, Agnese C., Sainas, Stefano, Vigato, Chiara, Mannella, Iole, Castellino, Irene, Kovachka, Sandra, Iakovleva, Mariia, Rolando, Barbara, Tomasz, Wrobel, Mirza, Osman A., Karla, Frydenvang, Spyrakis, Francesca, OLIARO BOSSO, Simonetta, Lolli, Marco L., Boschi, Donatella
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od_______970::14914218b23cf1d7b89ac5cd31f95bae
https://hdl.handle.net/2318/1909310
https://hdl.handle.net/2318/1909310
Autor:
Tuo Li, Xue Ma, Daniil Fedotov, Louise Kjaerulff, Karla Frydenvang, Sonia Coriani, Paul Robert Hansen, Kenneth T. Kongstad, Dan Staerk
Publikováno v:
Molecules, Vol 25, Iss 7, p 1706 (2020)
Crude ethyl acetate extract of Gerbera piloselloides (L.) Cass. was investigated by dual high-resolution PTP1B/α-glucosidase inhibition profiling and LC-PDA-HRMS. This indicated the presence of a series of unprecedented prenyl- and geranyl-substitut
Externí odkaz:
https://doaj.org/article/b3574d0e863c4e44af906dc9bfd82f9c
Publikováno v:
The Journal of Physiology. 600:181-200
This paper summarizes the present knowledge on how positive allosteric modulators (PAMs) interact with the ligand-binding domain (LBD) of AMPA and kainate receptors, based on structure determinations. AMPA and kainate receptors belong to the family o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d696d2a02e951acd56490c77c4c8cce
https://doi.org/10.1113/jp280873
https://doi.org/10.1113/jp280873
Autor:
Anne Mette Kærn, D. Sprogoe, Darryl S. Pickering, Jette S. Kastrup, Giridhar U. Kshirsagar, Giulia Chemi, Stefania Butini, Giuseppe Campiani, Sandra Gemma, Karla Frydenvang, Simone Brogi
Publikováno v:
ACS Chemical Neuroscience. 11:1791-1800
(S)-2-Amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic acid (AMPA) receptors comprise an important class of ionotropic glutamate receptors activated by glutamate in the central nervous system. Th...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::752228f075c082fae49a1210330c35bb
https://doi.org/10.1021/acschemneuro.0c00195
https://doi.org/10.1021/acschemneuro.0c00195
Publikováno v:
Makedonsko Farmacevtski Bilten, Vol 57, Iss (1, 2), Pp 3-16 (2011)
Ionotropic glutamate receptors (iGluRs) constitute a family of ligand gated ion channels subdivided in three classes, NMDA, AMPA (iGluA1-4) and KA (1-5) according to the agonists that selectively activate them. iGluRs are tetrameric assemblies of hig
Externí odkaz:
https://doaj.org/article/d287df465a054dc0b636ab6f06e5d564
Autor:
Kasper B. Hansen, Mikkel Krell-Jørgensen, Eloi Astier, Younes Larsen, Birgitte Nielsen, Jed T. Syrenne, Christian B. M. Poulie, Anna Alcaide, Feng Yi, Darryl S. Pickering, Morten Storgaard, Walden E. Bjørn-Yoshimoto, Karla Frydenvang, Lennart Bunch, Anders A. Jensen
Publikováno v:
ACS Chem Neurosci
Development of pharmacological tools for the ionotropic glutamate receptors (iGluRs) is imperative for the study and understanding of the role and function of these receptors in the central nervous system. We report the synthesis of 18 analogues of (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::390076e4d98182631a6a5e9f6f0470f4
https://doi.org/10.1021/acschemneuro.9b00205
https://doi.org/10.1021/acschemneuro.9b00205
Publikováno v:
The Journal of organic chemistry. 85(16)
We report the synthesis of a series of bis-functionalized b-peptoid oligomers of the hexamer length. This was achieved by synthesizing and incorporating protected amino- or azido-functionalized chiral building blocks into precursor oligomers by a tri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45907b9028c4b4b8c7e46a8e32defd1c
https://pubmed.ncbi.nlm.nih.gov/32806085
https://pubmed.ncbi.nlm.nih.gov/32806085
Autor:
Magdalena Masternak, Thomas Drapier, Jette S. Kastrup, Karla Frydenvang, Pierre Francotte, Bernard Pirotte, Saara Laulumaa, Kathrine Voigt Hansen
Publikováno v:
ACS Medicinal Chemistry Letters. 10:243-247
[Image: see text] The ionotropic glutamate receptor GluA2 is considered to be an attractive target for positive allosteric modulation for the development of pharmacological tools or cognitive enhancers. Here, we report a detailed structural character
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::caa39b00ab48193af9afe6aade30e38d
https://doi.org/10.1021/acsmedchemlett.8b00369
https://doi.org/10.1021/acsmedchemlett.8b00369
Autor:
Sebastian Winther, Thor Seneca Thorsen, Jette S. Kastrup, Raminta Venskutonytė, Laura Marconi, Stine Møllerud, Paola Conti, Darryl S. Pickering, Andrea Pinto, Lucia Tamborini, Karla Frydenvang, Saara Laulumaa, Ana Maria Cuñado Moral
Publikováno v:
ACS Chemical Neuroscience. 8:2056-2064
Ionotropic glutamate receptors (iGluRs) are involved in most of the fast excitatory synaptic transmission in the central nervous system. These receptors are important for learning and memory formation, but are also involved in the development of dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecc8a3370a56192c1f178bb9a26035ac
https://doi.org/10.1021/acschemneuro.7b00201
https://doi.org/10.1021/acschemneuro.7b00201