Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Karl-Heinz Tomaszowski"'
Autor:
Michael A. Longo, Sunetra Roy, Yue Chen, Karl-Heinz Tomaszowski, Andrew S. Arvai, Jordan T. Pepper, Rebecca A. Boisvert, Selvi Kunnimalaiyaan, Caezanne Keshvani, David Schild, Albino Bacolla, Gareth J. Williams, John A. Tainer, Katharina Schlacher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract RAD51C is an enigmatic predisposition gene for breast, ovarian, and prostate cancer. Currently, missing structural and related functional understanding limits patient mutation interpretation to homology-directed repair (HDR) function analysi
Externí odkaz:
https://doaj.org/article/3d21ced31b7c4fa39d8b21ed94cd204f
Autor:
Karl-Heinz Tomaszowski, Sunetra Roy, Carolina Guerrero, Poojan Shukla, Caezaan Keshvani, Yue Chen, Martina Ott, Xiaogang Wu, Jianhua Zhang, Courtney D. DiNardo, Detlev Schindler, Katharina Schlacher
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The prototypic cancer-predisposition disease Fanconi Anemia (FA) is identified by biallelic mutations in any one of twenty-three FANC genes. Puzzlingly, inactivation of one Fanc gene alone in mice fails to faithfully model the pleiotropic hu
Externí odkaz:
https://doaj.org/article/388412a5d9a24c389d84b1801b5d84c2
Autor:
Karl-Heinz Tomaszowski, Sunetra Roy, Carolina Guerrero, Poojan Shukla, Caezaan Keshvani, Yue Chen, Martina Ott, Xiaogang Wu, Jianhua Zhang, Courtney D. DiNardo, Detlev Schindler, Katharina Schlacher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/bdd8e1d34d054aafb53fa411bf22758e
Autor:
Martina Ott, Karl-Heinz Tomaszowski, Anantha Marisetty, Ling-Yuan Kong, Jun Wei, Maya Duna, Katia Blumberg, Xiaorong Ji, Carmen Jacobs, Gregory N. Fuller, Lauren A. Langford, Jason T. Huse, James P. Long, Jian Hu, Shulin Li, Jeffrey S. Weinberg, Sujit S. Prabhu, Raymond Sawaya, Sherise Ferguson, Ganesh Rao, Frederick F. Lang, Michael A. Curran, Amy B. Heimberger
Publikováno v:
JCI Insight, Vol 5, Iss 17 (2020)
In order to prioritize available immune therapeutics, immune profiling across glioma grades was conducted, followed by preclinical determinations of therapeutic effect in immune-competent mice harboring gliomas. T cells and myeloid cells were isolate
Externí odkaz:
https://doaj.org/article/bd19fbd424ce488a8909a2a850262eae
Autor:
Sunetra Roy, Karl-Heinz Tomaszowski, Jessica W Luzwick, Soyoung Park, Jun Li, Maureen Murphy, Katharina Schlacher
Publikováno v:
eLife, Vol 7 (2018)
Classically, p53 tumor suppressor acts in transcription, apoptosis, and cell cycle arrest. Yet, replication-mediated genomic instability is integral to oncogenesis, and p53 mutations promote tumor progression and drug-resistance. By delineating human
Externí odkaz:
https://doaj.org/article/d59ddfa5c38f4f2cae38704cb46a36dd
Autor:
Anna V Knizhnik, Wynand P Roos, Teodora Nikolova, Steve Quiros, Karl-Heinz Tomaszowski, Markus Christmann, Bernd Kaina
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e55665 (2013)
Apoptosis, autophagy, necrosis and cellular senescence are key responses of cells that were exposed to genotoxicants. The types of DNA damage triggering these responses and their interrelationship are largely unknown. Here we studied these responses
Externí odkaz:
https://doaj.org/article/d1805c316e3544fd8ddb9943073983b2
Autor:
Amy B. Heimberger, Erik P. Sulman, John DeGroot, Gregory N. Fuller, Ling-Yuan Kong, James P. Long, Jared K. Burks, Rafal J. Zielinski, Waldemar Priebe, Pravesh Gupta, Dexing Fang, Aria Sabbagh, Karl-Heinz Tomaszowski, Jia-Shiun Leu, Daniel Zamler, Jun Wei, Yuuri Hashimoto, Anantha Marisetty, Cynthia Kassab, Martina Ott
Table S1 shows KINOMEscan profiling of WP1066.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::255faf72e13c5b74de12ab3ca1c78a42
https://doi.org/10.1158/1078-0432.22475615
https://doi.org/10.1158/1078-0432.22475615
Autor:
Amy B. Heimberger, Erik P. Sulman, John DeGroot, Gregory N. Fuller, Ling-Yuan Kong, James P. Long, Jared K. Burks, Rafal J. Zielinski, Waldemar Priebe, Pravesh Gupta, Dexing Fang, Aria Sabbagh, Karl-Heinz Tomaszowski, Jia-Shiun Leu, Daniel Zamler, Jun Wei, Yuuri Hashimoto, Anantha Marisetty, Cynthia Kassab, Martina Ott
Video 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb9f1b020fa0ca0cbe30d9aa300ec945
https://doi.org/10.1158/1078-0432.22475606
https://doi.org/10.1158/1078-0432.22475606
Autor:
Amy B. Heimberger, Erik P. Sulman, John DeGroot, Gregory N. Fuller, Ling-Yuan Kong, James P. Long, Jared K. Burks, Rafal J. Zielinski, Waldemar Priebe, Pravesh Gupta, Dexing Fang, Aria Sabbagh, Karl-Heinz Tomaszowski, Jia-Shiun Leu, Daniel Zamler, Jun Wei, Yuuri Hashimoto, Anantha Marisetty, Cynthia Kassab, Martina Ott
Video
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21c37cecd66c0db92618288c81fe19b8
https://doi.org/10.1158/1078-0432.22475609.v1
https://doi.org/10.1158/1078-0432.22475609.v1
Autor:
Amy B. Heimberger, Erik P. Sulman, John DeGroot, Gregory N. Fuller, Ling-Yuan Kong, James P. Long, Jared K. Burks, Rafal J. Zielinski, Waldemar Priebe, Pravesh Gupta, Dexing Fang, Aria Sabbagh, Karl-Heinz Tomaszowski, Jia-Shiun Leu, Daniel Zamler, Jun Wei, Yuuri Hashimoto, Anantha Marisetty, Cynthia Kassab, Martina Ott
Supplementary Figure legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c1269d95c12c87288289afc586c3808
https://doi.org/10.1158/1078-0432.22475618.v1
https://doi.org/10.1158/1078-0432.22475618.v1