Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Karl-Heinz Kostka"'
Autor:
Ulrich F. Schaefer, Karl-Heinz Kostka, Claus-Michael Lehr, Dominik Selzer, Dirk Neumann, Heike Neumann
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 95:68-76
For some time, in-silico models to address substance transport into and through the skin are gaining more and more importance in different fields of science and industry. In particular, the mathematical prediction of in-vivo skin absorption is of gre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2d92975a6611315dbb8cedc89f3c7d
https://doi.org/10.1016/j.ejpb.2015.05.002
https://doi.org/10.1016/j.ejpb.2015.05.002
Autor:
Adriana Raffin Pohlmann, Aline Ferreira Ourique, Ruy Carlos Ruver Beck, Silvia Stanisçuaski Guterres, Claus-Michael Lehr, Ana Melero, Cristiane de Bona da Silva, Ulrich F. Schaefer, Karl-Heinz Kostka
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 79:95-101
The aims of this work were to increase the photostability and to reduce the skin permeation of tretinoin through nanoencapsulation. Tretinoin is widely used in the topical treatment of various dermatological diseases such as acne, psoriasis, skin can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e2a757e1d440cf40d28b00b2bd43f6
https://doi.org/10.1016/j.ejpb.2011.03.008
https://doi.org/10.1016/j.ejpb.2011.03.008
Autor:
Mingyuan Gao, Renata Fonseca Vianna Lopez, Marc Schneider, Tais Gratieri, Lihong Jing, Ulrich F. Schaefer, Karl-Heinz Kostka
Publikováno v:
Journal of Biomedical Nanotechnology. 6:586-595
The skin is a large and accessible area of the body, offering the possibility to be used as an alternative route for drug delivery. In the last few years strong progress has been made on the developing of nanoparticulate systems for specific applicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5694121d39e9e37f9d819ade1ec99b7
https://doi.org/10.1166/jbn.2010.1155
https://doi.org/10.1166/jbn.2010.1155
Autor:
Ana Melero, Ulrich F. Schaefer, Karl-Heinz Kostka, T.M. Garrigues, M. Alós, Claus-Michael Lehr
Publikováno v:
International Journal of Pharmaceutics. 378:101-107
The objective of this work was to develop a simple and inexpensive transdermal formulation containing Nortriptyline Hydrochloride (NTH) for smoking cessation support therapy. Hydroxypropyl-methyl-cellulose was chosen as polymer and a mixture of trans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00af961a812dccf80bf057314a73eac9
https://doi.org/10.1016/j.ijpharm.2009.05.048
https://doi.org/10.1016/j.ijpharm.2009.05.048
Autor:
Andreas Henning, Gabriel Wittum, Ulrich F. Schaefer, Claus-Michael Lehr, Karl-Heinz Kostka, Dirk Neumann, Jarmila Zbytovská, Arne Naegel, Steffi Hansen, Michael Heisig
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 68:352-367
Mathematical modeling of skin transport is considered a valuable alternative of in-vitro and in-vivo investigations especially considering ethical and economical questions. Mechanistic diffusion models describe skin transport by solving Fick's 2nd la
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41893f20a4cebca174177b2bc309e49b
https://doi.org/10.1016/j.ejpb.2007.05.012
https://doi.org/10.1016/j.ejpb.2007.05.012
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 55:57-65
Investigations to determine pH profiles across human stratum corneum (SC), in vivo as well as in vitro, were carried out using the tape stripping technique and a flat surface pH electrode. This method was extended to the deeper skin layers (=viable e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ed8de4061c1a257bf1f97a300bce646
https://doi.org/10.1016/s0939-6411(02)00125-x
https://doi.org/10.1016/s0939-6411(02)00125-x
Autor:
Ulrich F. Schaefer, Claus-Michael Lehr, Dominik Selzer, Dirk Neumann, Karl-Heinz Kostka, Tsambika Hahn
Publikováno v:
Experimental Dermatology. 21:233-235
For finite dose skin absorption experiments, a homogeneous donor distribution over the skin surface is usually assumed. However, the influence of the surface distribution on skin absorption is still unknown. The aim of this study was to evaluate the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::016c41b5f032bf1627f4ff9189f1db0b
https://doi.org/10.1111/j.1600-0625.2011.01424.x
https://doi.org/10.1111/j.1600-0625.2011.01424.x
Publikováno v:
Journal of Pharmaceutical Sciences. 91:1915-1921
The stratum corneum of various donors differs in particular in the composition of the lipoidal phase. Considering the drug amounts penetrating into the stratum corneum a simple methodology to correlate these differences in the stratum corneum composi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4323cdf6de2bbb8e30f72e748368e84
https://doi.org/10.1002/jps.10183
https://doi.org/10.1002/jps.10183
Publikováno v:
Journal of Investigative Dermatology. 118:540-544
Previously, the interest in in vivo / in vitro correlations in the dermal field of research has increased steadily. Unfortunately, in most cases the skin from different human donors was taken for in vivo and in vitro experiments, which led to problem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1275cd70fee3bd6b6df52eac295b1897
https://doi.org/10.1046/j.0022-202x.2001.01688.x
https://doi.org/10.1046/j.0022-202x.2001.01688.x
Publikováno v:
Experimental dermatology. 23(12)
In the area of dermatological research, the knowledge of rate and extent of substance penetration into the human skin is essential not only for evaluation of therapeutics, but also for risk assessment of chemicals and cosmetic ingredients. Recently,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b218ade606f82f3131cc28df5f84459
https://pubmed.ncbi.nlm.nih.gov/25219950
https://pubmed.ncbi.nlm.nih.gov/25219950