Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Karl-Heinz Gührs"'
Autor:
Mohamad A. Zaini, Christine Müller, Tristan V. de Jong, Tobias Ackermann, Götz Hartleben, Gertrud Kortman, Karl-Heinz Gührs, Fabrizia Fusetti, Oliver H. Krämer, Victor Guryev, Cornelis F. Calkhoven
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 497-511 (2018)
Summary: Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic pathways in response to changes in nutrient supply. Among the transcription factors that regulate gene expression and thereby cause changes
Externí odkaz:
https://doaj.org/article/b89c785701114568b66cb56f03f0941a
Publikováno v:
PeerJ, Vol 3, p e754 (2015)
Mercury (Hg) is a bioaccumulating trace metal that globally circulates the atmosphere and waters in its elemental, inorganic and organic chemical forms. While Hg represents a notorious neurotoxicant, the underlying cellular pathways are insufficientl
Externí odkaz:
https://doaj.org/article/7a286878ce3644a3b81deaa97511d806
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81926 (2013)
The amyloid precursor protein (APP) and its processing by the α-, β- and γ-secretases is widely believed to play a central role during the development of Alzheimer´s disease. The three-dimensional structure of the entire protein, its physiologic
Externí odkaz:
https://doaj.org/article/db98e990c52943a7b53f1f35bda64cd5
Autor:
Tristan V. de Jong, Cornelis F. Calkhoven, Karl-Heinz Gührs, Mohamad A. Zaini, Oliver H. Krämer, Victor Guryev, Götz Hartleben, Christine Müller, Gertrud Kortman, Fabrizia Fusetti, Tobias Ackermann
Publikováno v:
Cell Reports, Vol 22, Iss 2, Pp 497-511 (2018)
Cell reports, 22(2), 497-511. CELL PRESS
Cell reports, 22(2), 497-511. CELL PRESS
Summary: Cellular metabolism is a tightly controlled process in which the cell adapts fluxes through metabolic pathways in response to changes in nutrient supply. Among the transcription factors that regulate gene expression and thereby cause changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983d3f620348d3e721ee7d9baa53e4f1
https://doi.org/10.1016/j.celrep.2017.12.061
https://doi.org/10.1016/j.celrep.2017.12.061
Autor:
Marie-Theres Vielberg, Karl-Heinz Gührs, Andreas Schmidt, Rolf Koehler, Stefan Schönland, Marcus Fändrich, Angelika Schierhorn, Matthias Schmidt, William Close, Hauke Lilie, Falk Liberta, Christian Haupt, Ute Hegenbart, Karthikeyan Annamalai, Michael Groll
Publikováno v:
Angewandte Chemie. 129:7618-7622
Systemic amyloidosis is caused by the misfolding of a circulating amyloid precursor protein and the deposition of amyloid fibrils in multiple organs. Chemical and biophysical analysis of amyloid fibrils from human AL and murine AA amyloidosis reveal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98f03a22a9169be54f89d632b09dfd9e
https://doi.org/10.1002/ange.201701761
https://doi.org/10.1002/ange.201701761
Autor:
Ute Hegenbart, Marcus Fändrich, Karl-Heinz Gührs, Patricia M. Gaffney, Christina J. Sigurdson, Karthikeyan Annamalai, Rolf Koehler, Stefan Schönland, Henri Michel, Cornelia Loos, Matthias Schmidt
Publikováno v:
Angewandte Chemie. 128:4903-4906
Polymorphismus ist ein weit verbreitetes Merkmal von in vitro gebildeten Amyloid-artigen Fibrillen, doch blieb bislang unklar, ob Amyloidfibrillen in vivo ebenso von diesem Phanomen betroffen sind. Hier zeigen wir, dass sich verschiedene innerhalb ei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a4cbb909a7c5a9dd40dfdb343d2e20a
https://doi.org/10.1002/ange.201511524
https://doi.org/10.1002/ange.201511524
Autor:
Rolf Koehler, Christina J. Sigurdson, Matthias Schmidt, Henri Michel, Patricia M. Gaffney, Marcus Fändrich, Karl-Heinz Gührs, Karthikeyan Annamalai, Stefan Schönland, Ute Hegenbart, Cornelia Loos
Publikováno v:
Angewandte Chemie International Edition. 55:4822-4825
Polymorphism is a wide-spread feature of amyloid-like fibrils formed in vitro, but it has so far remained unclear whether the fibrils formed within a patient are also affected by this phenomenon. In this study we show that the amyloid fibrils within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daaa67323ac09af81c914dabe0396971
https://doi.org/10.1002/anie.201511524
https://doi.org/10.1002/anie.201511524
Autor:
Michel Monod, Oumaïma Ibrahim-Granet, Rajashri Shende, Rémi Beau, Jean-Paul Latgé, Karl-Heinz Gührs, Taruna Madan, Jayanta K. Pal, Arvind Sahu, Vishukumar Aimanianda, Sarah Sze Wah Wong, Srikanth Rapole
Publikováno v:
Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (40), pp.15538-15555. ⟨10.1074/jbc.RA117.001476⟩
Journal of Biological Chemistry, 2018, 293 (40), pp.15538-15555. ⟨10.1074/jbc.RA117.001476⟩
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (40), pp.15538-15555. ⟨10.1074/jbc.RA117.001476⟩
Journal of Biological Chemistry, 2018, 293 (40), pp.15538-15555. ⟨10.1074/jbc.RA117.001476⟩
International audience; Innate immunity in animals including humans encompasses the complement system, which is considered an important host defense mechanism against Aspergillus fumigatus, one of the most ubiquitous opportunistic human fungal pathog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f61a53a45ed1816d0f371456e3abfc
https://hal-pasteur.archives-ouvertes.fr/pasteur-02501371
https://hal-pasteur.archives-ouvertes.fr/pasteur-02501371
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1510
Posttranslational acetylation of lysine residues has been discovered as multifaceted regulatory modification for various nuclear, cytoplasmic, and mitochondrial proteins. The implementation of high-resolution and high-throughput mass spectrometry (MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::80d537c2ee494c56236effbc87a2a68a
https://pubmed.ncbi.nlm.nih.gov/27761831
https://pubmed.ncbi.nlm.nih.gov/27761831
Publikováno v:
Methods in Molecular Biology ISBN: 9781493965250
Posttranslational acetylation of lysine residues has been discovered as multifaceted regulatory modification for various nuclear, cytoplasmic, and mitochondrial proteins. The implementation of high-resolution and high-throughput mass spectrometry (MS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e413fa7c671c2a87fc245a8c78ec49c
https://doi.org/10.1007/978-1-4939-6527-4_23
https://doi.org/10.1007/978-1-4939-6527-4_23