Zobrazeno 1 - 10
of 350
pro vyhledávání: '"Karl-Heinz Altmann"'
Autor:
Andrea E Prota, Daniel Lucena-Agell, Yuntao Ma, Juan Estevez-Gallego, Shuo Li, Katja Bargsten, Fernando Josa-Prado, Karl-Heinz Altmann, Natacha Gaillard, Shinji Kamimura, Tobias Mühlethaler, Federico Gago, Maria A Oliva, Michel O Steinmetz, Wei-Shuo Fang, J Fernando Díaz
Publikováno v:
eLife, Vol 12 (2023)
Paclitaxel (Taxol) is a taxane and a chemotherapeutic drug that stabilizes microtubules. While the interaction of paclitaxel with microtubules is well described, the lack of high-resolution structural information on a tubulin-taxane complex precludes
Externí odkaz:
https://doaj.org/article/ae0411d1a2f8477a839b678a56356407
Autor:
Jean-Marc Jeckelmann, Jonas Zaugg, Veronika Morozova, Jennifer Müller, Satish Kantipudi, Mariana Schroeder, Julien Graff, Christiane Albrecht, Karl-Heinz Altmann, Jürg Gertsch, Dimitrios Fotiadis
Publikováno v:
CHIMIA, Vol 76, Iss 12 (2022)
Amino acids are essential components of all living cells serving as building blocks of proteins, as energy source, and as precursors of metabolites and signaling molecules. Amino acid transporters are membrane proteins that mediate the transfer of am
Externí odkaz:
https://doaj.org/article/eced44bd17e44a3f86e4513d38f6789c
Autor:
Karl-Heinz Altmann
Publikováno v:
CHIMIA, Vol 76, Iss 5 (2022)
Externí odkaz:
https://doaj.org/article/f369d79080694381a37f7c389785f6d6
Publikováno v:
CHIMIA, Vol 76, Iss 5 (2022)
The computer-assisted design of new chemical entities has made a leap forward with the development of machine learning models for automated molecule generation. The overarching goal of this conceptual approach is to augment the creativity of medicina
Externí odkaz:
https://doaj.org/article/f27caec299d642a58a1b8fe6654b4da3
Autor:
Renhong Yan, Yaning Li, Jennifer Müller, Yuanyuan Zhang, Simon Singer, Lu Xia, Xinyue Zhong, Jürg Gertsch, Karl-Heinz Altmann, Qiang Zhou
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract LAT1 (SLC7A5) is one of the representative light chain proteins of heteromeric amino acid transporters, forming a heterodimer with its heavy chain partner 4F2hc (SLC3A2). LAT1 is overexpressed in many types of tumors and mediates the transfe
Externí odkaz:
https://doaj.org/article/5519880d1f784d94a4c45a0208921b2a
Autor:
Louisa Warryn, Jean-Pierre Dangy, Philipp Gersbach, Matthias Gehringer, Anja Schäfer, Marie-Thérèse Ruf, Nicolas Ruggli, Karl-Heinz Altmann, Gerd Pluschke
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008357 (2020)
Mycolactones, macrolide cytotoxins, are key virulence factors of Mycobacterium ulcerans, the etiological agent of the chronic necrotizing skin disease Buruli ulcer. There is urgent need for a simple point-of-care laboratory test for Buruli ulcer and
Externí odkaz:
https://doaj.org/article/deaf562998254bd3ae3722701aa7df5e
The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model
Autor:
Pascal Häfliger, Julien Graff, Matthias Rubin, Amandine Stooss, Matthias S. Dettmer, Karl-Heinz Altmann, Jürg Gertsch, Roch-Philippe Charles
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 37, Iss 1, Pp 1-15 (2018)
Abstract Background The L-type amino acid transporter 1 (LAT1/SLC7A5) transports essential amino acids across the plasma membrane. While LAT1 is overexpressed in a variety of human neoplasms, its expression and its role in thyroid cancer is currently
Externí odkaz:
https://doaj.org/article/8eacdf8b41754b9abae1d4b4b79be208
Autor:
Grégory Menchon, Andrea E. Prota, Daniel Lucena-Agell, Pascal Bucher, Rolf Jansen, Herbert Irschik, Rolf Müller, Ian Paterson, J. Fernando Díaz, Karl-Heinz Altmann, Michel O. Steinmetz
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
Microtubule-targeting agents are used successfully as anticancer therapeutics. Here authors develop a fluorescence-anisotropy-based assay to identify and characterize ligands for the maytansine site of tubulin and provide crystal structures of identi
Externí odkaz:
https://doaj.org/article/0ff5964567e04f11ab1504ca1c9d29cf
Autor:
Matthias Gehringer, Karl-Heinz Altmann
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 1596-1660 (2017)
Mycolactones are a group of macrolides excreted by the human pathogen Mycobacterium ulcerans, which exhibit cytotoxic, immunosuppressive and analgesic properties. As the virulence factor of M. ulcerans, mycolactones are central to the pathogenesis of
Externí odkaz:
https://doaj.org/article/4ea2205718c24001a911333ec34d2f80
Autor:
Caroline S. Foo, Andréanne Lupien, Maryline Kienle, Anthony Vocat, Andrej Benjak, Raphael Sommer, Dirk A. Lamprecht, Adrie J. C. Steyn, Kevin Pethe, Jérémie Piton, Karl-Heinz Altmann, Stewart T. Cole
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT New drugs are needed to control the current tuberculosis (TB) pandemic caused by infection with Mycobacterium tuberculosis. We report here on our work with AX-35, an arylvinylpiperazine amide, and four related analogs, which are potent antit
Externí odkaz:
https://doaj.org/article/adb9ac67e2c14c6b855d0f2b8719a48c