Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Karl-Heinz, Klempnauer"'
Autor:
Karl-Heinz Klempnauer
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 6, p 3231 (2024)
The MYB protein is a pivotal player in the cellular transcriptional network, influencing major important processes such as cell proliferation, differentiation, and apoptosis. Because of its role in oncogenesis, MYB is now a compelling target for ther
Externí odkaz:
https://doaj.org/article/3158684e5e3044bfadb69a0b94f21520
Publikováno v:
BBA Advances, Vol 2, Iss , Pp 100034- (2022)
A large body of work has shown that MYB acts as a master transcription regulator in hematopoietic cells and has pinpointed MYB as a potential drug target for acute myeloid leukemia (AML). Here, we have examined the MYB-inhibitory potential of the HDA
Externí odkaz:
https://doaj.org/article/bf2e6bbeff074621b97b1746d59ec016
Publikováno v:
Cells, Vol 11, Iss 7, p 1162 (2022)
Recent studies have disclosed transcription factor MYB as a potential drug target for malignancies that are dependent on deregulated MYB function, including acute myeloid leukemia (AML) and adenoid cystic carcinoma (ACC). Although transcription facto
Externí odkaz:
https://doaj.org/article/6db7f5a532f7406e801f03cfa85a2ff0
Publikováno v:
Molecules, Vol 27, Iss 7, p 2077 (2022)
The transcription factor MYB is expressed predominantly in hematopoietic progenitor cells, where it plays an essential role in the development of most lineages of the hematopoietic system. In the myeloid lineage, MYB is known to cooperate with member
Externí odkaz:
https://doaj.org/article/9e84f5d571c24d399d6663b5c8b07ef7
Autor:
Karl-Heinz Klempnauer
Publikováno v:
Oncotarget. 14:174-177
Autor:
Leonhard H. F. Köhler, Sebastian Reich, Maria Yusenko, Karl-Heinz Klempnauer, Gerrit Begemann, Rainer Schobert, Bernhard Biersack
Publikováno v:
Cancer Drug Resistance. 6:59-78
Aim: Efficient and readily available anticancer drugs are sought as treatment options. For this reason, chromene derivatives were prepared using the one-pot reaction and tested for their anticancer and anti-angiogenic properties. Methods: 2-Amino-3-c
Autor:
Maria V. Yusenko, Abhiruchi Biyanee, Daria Frank, Leonhard H. F. Köhler, Mattias K. Andersson, Cyrus Khandanpour, Rainer Schobert, Göran Stenman, Bernhard Biersack, Karl-Heinz Klempnauer
Publikováno v:
Cancers, Vol 14, Iss 1, p 43 (2021)
Studies of the role of MYB in human malignancies have highlighted MYB as a potential drug target for acute myeloid leukemia (AML) and adenoid cystic carcinoma (ACC). Here, we present the initial characterization of 2-amino-4-(3,4,5-trimethoxyphenyl)-
Externí odkaz:
https://doaj.org/article/874f8c2163b947f4a23a51099bf0d508
Autor:
Leonhard H. F. Köhler, Sebastian Reich, Maria Yusenko, Karl-Heinz Klempnauer, Amin H. Shaikh, Khursheed Ahmed, Gerrit Begemann, Rainer Schobert, Bernhard Biersack
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1783-1790
Autor:
Karl-Heinz Klempnauer, Joachim Jose, Michael Goblirsch, Bertan Bopp, Sandeep Dukare, Sagar Uttarkar
Suppl. Fig. 1. Analysis of the c-Myb/CBP interaction by microscale thermophoresis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5baab4d9a1cf6a95399c2cb3294ff784
https://doi.org/10.1158/1535-7163.22499746.v1
https://doi.org/10.1158/1535-7163.22499746.v1
Autor:
Karl-Heinz Klempnauer, Joachim Jose, Michael Goblirsch, Bertan Bopp, Sandeep Dukare, Sagar Uttarkar
The transcription factor c-Myb is highly expressed in hematopoietic progenitor cells and controls the transcription of genes important for lineage determination, cell proliferation, and differentiation. Deregulation of c-Myb has been implicated in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a42251dcd1c4cd679d53209f79007864
https://doi.org/10.1158/1535-7163.c.6536242
https://doi.org/10.1158/1535-7163.c.6536242