Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry - Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort

Autor: Steven Gendreau, Martina Haberecker, Ata Tuna Ciftlik, Keith M. Kerr, Roswitha Kammler, Solange Peters, Richard Cheney, Kim Monkhorst, Karl-Friedrich Deml, Undine Rulle, Ruben Casanova, Irene Sansano, Bart Vrugt, Zoi Tsourti, Ernst-Jan M. Speel, Chengguang Wu, Rolf A. Stahel, Eric Verbeken, Antonio Marchetti, Urania Dafni, Thomas Geiger, Peter J. Wild, Walter Weder, Lukas Bubendorf, Arne Warth, Line Bille Madsen, Atilio Navarro, Panagiota Zygoura, Aleksandra Sejda, Holger Moch, Katja Schulze, Daisuke Nonaka, Erik Thunnissen, Alex Soltermann, Stephen P. Finn

Publikováno v: Journal of Thoracic Oncology, 13(12), 1851-1863. Elsevier Science
Journal of thoracic oncology, vol. 13, no. 12, pp. 1851-1863
Rulle, U, Tsourti, Z, Casanova, R, Deml, K-F, Verbeken, E, Thunnissen, E, Warth, A, Cheney, R, Sejda, A, Speel, E J, Madsen, L B, Nonaka, D, Navarro, A, Sansano, I, Marchetti, A, Finn, S P, Monkhorst, K, Kerr, K M, Haberecker, M, Wu, C, Zygoura, P, Kammler, R, Geiger, T, Gendreau, S, Schulze, K, Vrugt, B, Wild, P, Moch, H, Weder, W, Ciftlik, A T, Dafni, U, Peters, S, Bubendorf, L, Stahel, R A & Soltermann, A 2018, ' Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry — Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort ', Journal of Thoracic Oncology, vol. 13, no. 12, pp. 1851-1863 . https://doi.org/10.1016/j.jtho.2018.08.2034
Rulle, U, Tsourti, Z, Casanova, R, Deml, K F, Verbeken, E, Thunnissen, E, Warth, A, Cheney, R, Sejda, A, Speel, E J, Madsen, L B, Nonaka, D, Navarro, A, Sansano, I, Marchetti, A, Finn, S P, Monkhorst, K, Kerr, K M, Haberecker, M, Wu, C, Zygoura, P, Kammler, R, Geiger, T, Gendreau, S, Schulze, K, Vrugt, B, Wild, P, Moch, H, Weder, W, Ciftlik, A T, Dafni, U, Peters, S, Bubendorf, L, Stahel, R A & Soltermann, A 2018, ' Computer-Based Intensity Measurement Assists Pathologists in Scoring Phosphatase and Tensin Homolog Immunohistochemistry — Clinical Associations in NSCLC Patients of the European Thoracic Oncology Platform Lungscape Cohort ', Journal of Thoracic Oncology, vol. 13, no. 12, pp. 1851-1863 . https://doi.org/10.1016/j.jtho.2018.08.2034
Journal of Thoracic Oncology, 13(12), 1851-1863. International Association for the Study of Lung Cancer

Introduction: Phosphatase and tensin homolog (PTEN) loss is frequently observed in NSCLC and associated with both phosphoinositide 3-kinase activation and tumoral immunosuppression. PTEN immunohistochemistry is a valuable readout, but lacks standardi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fb2ccb7d2d967cc5751810d904963d5
https://cris.maastrichtuniversity.nl/en/publications/7b1f4130-0c4b-476b-acd0-1c8545a2ec7a

Chromogenic in situ hybridization is a reliable assay for detection of ALK rearrangements in adenocarcinomas of the lung

Autor: Sabine Merkelbach-Bruse, Reinhard Büttner, Karl-Friedrich Deml, Maren Meiboom, Elke Binot, Sven Hauke, Katja Schmitz, Hans-Ulrich Schildhaus

Publikováno v: Modern Pathology. 26:1468-1477

Reliable detection of anaplastic lymphoma kinase (ALK) rearrangements is a prerequisite for personalized treatment of lung cancer patients, as ALK rearrangements represent a predictive biomarker for the therapy with specific tyrosine kinase inhibitor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15120bb071059a404e253c6b71d59c0
https://doi.org/10.1038/modpathol.2013.95

Interactions of histamine H1-receptor agonists and antagonists with the human histamine H4-receptor

Autor: Detlef Neumann, Andrea Strasser, Karl-Friedrich Deml, Roland Seifert, Silke Beermann

Publikováno v: Molecular pharmacology. 76(5)

The human histamine H(4)-receptor (hH(4)R) possesses high constitutive activity and, like the human H(1)-receptor (hH(1)R), is involved in the pathogenesis of type-I allergic reactions. The study aims were to explore the value of dual H(1)/H(4)R anta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8fea87858a7b80b153f4827ceaf57f4
https://pubmed.ncbi.nlm.nih.gov/19720730