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Autor:
Karl-Artur Kovar, Leo Hermle
Publikováno v:
InFo Neurologie & Psychiatrie. 18:36-46
Als „Legal Highs“ werden chemische psychoaktive Substanzen bezeichnet, deren molekulare Struktur Variationen von vorhandenen (illegalen) Substanzen sind oder vollig neue chemische Strukturen darstellen. Diese Substanzen sind in Europa und damit a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::424ba43d653f3c658542a1e72118fe81
https://doi.org/10.1007/s15005-016-1593-z
https://doi.org/10.1007/s15005-016-1593-z
Autor:
Karsten Heekeren, Euphrosyne Gouzoulis-Mayfrank, A. Neukirch, M. Stoll, M. Obradovic, Karl-Artur Kovar, Carsten Stock
Publikováno v:
Pharmacopsychiatry. 38:301-311
Introduction: Pharmacological challenges with hallucinogens are used as models for psychosis in experimental research. The state induced by glutamate antagonists such as phencyclidine (PCP) is often considered as a more appropriate model of psychosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88d63e8bd2218c25566a0e886d806a1f
https://doi.org/10.1055/s-2005-916185
https://doi.org/10.1055/s-2005-916185
Publikováno v:
Addiction Biology. 10:243-249
Recent studies have revealed the effectiveness of 2-methyl-6-(phenylethynyl)pyridine (MPEP), a highly selective antagonist of metabotropic glutamate receptors subtype 5 (mGluR5), in conditioned drug reward. In a previous study we showed that MPEP blo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81d89de55d1790351acc74c70ae930f
https://doi.org/10.1080/13556210500223272
https://doi.org/10.1080/13556210500223272
Publikováno v:
Synapse. 55:148-155
We have shown recently that 3,4-methylenedioxymethamphetamine (MDMA) has symptomatic antiparkinsonian activity in rodent models of Parkinson's disease. In search of its mechanism of action, we further investigated the enantiomers of MDMA in the rotat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3a9cc951593acbc8e38a7b92e3c773
https://doi.org/10.1002/syn.20102
https://doi.org/10.1002/syn.20102
Autor:
Helmut Heinle, Olaf Kelber, Dieter Weiser, Karl-Artur Kovar, Ines Germann, Gudrun Roos, Kim Wuthold
Publikováno v:
Journal of Chromatographic Science. 42:306-309
In most cases the pharmacological activity of plant extracts is not assigned to single components and often not all active ingredients are known. Approaches other than those considering single compounds only to analyze plant material have proven help
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0d7cf45e98f780dad0847f3e79de45e
https://doi.org/10.1093/chromsci/42.6.306
https://doi.org/10.1093/chromsci/42.6.306
Autor:
Claudia Marx, Matthias Schwab, Gerd Mikus, Georg Grön, Karl Artur Kovar, Jochen Buechler, Manfred Spitzer, Leo Hermle, Beate Fischer
Publikováno v:
Journal of Chromatography B. 793:207-222
An enantioselective HPLC method has been developed and validated for the stereospecific analysis of N -ethyl-3,4-methylenedioxyamphetamine (MDE) and its major metabolites N -ethyl-4-hydroxy-3-methoxyamphetamine (HME) and 3,4-methylenedioxyamphetamine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4804016458ceccf0f2cee3a3a85ec774
https://doi.org/10.1016/s1570-0232(03)00266-6
https://doi.org/10.1016/s1570-0232(03)00266-6
Publikováno v:
Journal of Neural Transmission. 110:707-718
3,4-Methylenedioxymethamphetamine (MDMA) has recently been hypothesized to be effective against the symptoms of Parkinson's disease. Therefore we tested the effects of MDMA-derivatives in the rotational behavioural model. Male Sprague Dawley rats wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e711d8b81b9f2fa982d759ca19ec216f
https://doi.org/10.1007/s00702-003-0823-y
https://doi.org/10.1007/s00702-003-0823-y
Publikováno v:
Journal of Planar Chromatography – Modern TLC. 16:15-18
HPTLC with multivariate data analysis has been used as a new means of evaluating the quality of herbal extracts. Spectral data from three-dimensional chromatograms obtained from St John’s wort ( Hypericum perforatum ) extracts were correlated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71d0ff132370444810cdd19a8e355bc1
https://doi.org/10.1556/jpc.16.2003.1.3
https://doi.org/10.1556/jpc.16.2003.1.3
Publikováno v:
Neuroscience Letters. 330:193-197
The metabolism of MDA (3,4-methylenedioxyamphetamine), HMMA (3-hydroxy-4-methoxymethylamphetamine) and HME (3-hydroxy-4-methoxyethylamphetamin) of the popular designer drugs MDMA (‘ecstasy’, 3,4-methylenedioxymethamphetamine) and MDE (‘eve’,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85eae08997d3319f98da94c1a793ebab
https://doi.org/10.1016/s0304-3940(02)00776-0
https://doi.org/10.1016/s0304-3940(02)00776-0