Zobrazeno 1 - 10
of 69
pro vyhledávání: '"Karl Worm"'
Autor:
Carina Heydt, Christina B. Wölwer, Oscar Velazquez Camacho, Svenja Wagener-Ryczek, Roberto Pappesch, Janna Siemanowski, Jan Rehker, Florian Haller, Abbas Agaimy, Karl Worm, Thomas Herold, Nicole Pfarr, Wilko Weichert, Thomas Kirchner, Andreas Jung, Jörg Kumbrink, Wolfgang Goering, Irene Esposito, Reinhard Buettner, Axel M. Hillmer, Sabine Merkelbach-Bruse
Publikováno v:
BMC Medical Genomics, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Background Gene fusions represent promising targets for cancer therapy in lung cancer. Reliable detection of multiple gene fusions is therefore essential. Methods Five commercially available parallel sequencing assays were evaluated for thei
Externí odkaz:
https://doaj.org/article/44bdb1f0d72743ee9374126053306f77
Autor:
Frank Breitenbuecher, Sandra Hoffarth, Karl Worm, Diana Cortes-Incio, Thomas C Gauler, Jens Köhler, Thomas Herold, Kurt Werner Schmid, Lutz Freitag, Stefan Kasper, Martin Schuler
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85350 (2014)
BACKGROUND: Oncogenic mutations are powerful predictive biomarkers for molecularly targeted cancer therapies. For mutation detection patients have to undergo invasive tumor biopsies. Alternatively, archival samples are used which may no longer reflec
Externí odkaz:
https://doaj.org/article/7f0a02671f7148c3b3d30a83fe7b677b
Autor:
Sebastian Bauer, Jonathan A. Fletcher, Stefan Fröhling, Peter Hohenberger, Peter Horak, Benedikt Brors, Albrecht Stenzinger, Hanno Glimm, Hans-Ulrich Schildhaus, Thomas Herold, Stefanie Bertram, Karl Worm, Jürgen Treckmann, Eva Wardelmann, Wolfgang Hartmann, Marcel Trautmann, Adrian Marino-Enriquez, Susanne Grunewald, Michael C. Heinrich, Julia Ketzer, Thomas Mühlenberg
Sporadic gastrointestinal stromal tumors (GIST), characterized by activating mutations of KIT or PDGFRA, favorably respond to KIT inhibitory treatment but eventually become resistant. The development of effective salvage treatments is complicated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23adb7dca5bd417d759dcce3066cef7d
https://doi.org/10.1158/1535-7163.c.6539607
https://doi.org/10.1158/1535-7163.c.6539607
Autor:
Sebastian Bauer, Jonathan A. Fletcher, Stefan Fröhling, Peter Hohenberger, Peter Horak, Benedikt Brors, Albrecht Stenzinger, Hanno Glimm, Hans-Ulrich Schildhaus, Thomas Herold, Stefanie Bertram, Karl Worm, Jürgen Treckmann, Eva Wardelmann, Wolfgang Hartmann, Marcel Trautmann, Adrian Marino-Enriquez, Susanne Grunewald, Michael C. Heinrich, Julia Ketzer, Thomas Mühlenberg
Supplemental Methods; Supplemental Figure S1: Cancer-related mutations in the DKTK-Master patient cohort; Supplemental Figure S2: T1-PTEN cells were treated with increasing concentrations of approved KIT-inhibitors for 72h and analyzed by SRB assay;
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9065dee29f5f6a66402da93bf1874b2c
https://doi.org/10.1158/1535-7163.22510395.v1
https://doi.org/10.1158/1535-7163.22510395.v1
Autor:
Stefanie Bertram, Wolfgang Hartmann, Peter Horak, Thomas Mühlenberg, Thomas Herold, Peter Hohenberger, Adrián Mariño-Enríquez, Juergen Treckmann, Julia Ketzer, Benedikt Brors, Hanno Glimm, Susanne Grunewald, Karl Worm, Jonathan A. Fletcher, Marcel Trautmann, Stefan Fröhling, Albrecht Stenzinger, Michael Heinrich, Sebastian Bauer, Eva Wardelmann, Hans-Ulrich Schildhaus
Publikováno v:
Molecular Cancer Therapeutics. 18:1985-1996
Sporadic gastrointestinal stromal tumors (GIST), characterized by activating mutations of KIT or PDGFRA, favorably respond to KIT inhibitory treatment but eventually become resistant. The development of effective salvage treatments is complicated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d107615103d5446a3254b1899d80c50
https://doi.org/10.1158/1535-7163.mct-18-1224
https://doi.org/10.1158/1535-7163.mct-18-1224
Autor:
Henning Feist, Thomas Hager, Ben Davidson, Karl Worm, Kurt Werner Schmid, Horst Ostertag, Jeremias Wohlschlaeger, Jochen Peters
Publikováno v:
International Journal of Gynecological Pathology. 38:459-463
Papillomas of the fallopian tube are exceedingly rare benign tumors, and only very few cases have been reported in the literature. Clinically, they may present as a mass lesion or occur without symptoms. Histomorphologically, they are papillary tumor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::288f27f3d2cb03077d18b8e83a2f4aeb
https://doi.org/10.1097/pgp.0000000000000526
https://doi.org/10.1097/pgp.0000000000000526
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 3845, p 3845 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 8
International Journal of Molecular Sciences
Volume 22
Issue 8
Quantifying O⁶-methylguanine-DNA methyltransferase (MGMT) promoter methylation plays an essential role in assessing the potential efficacy of alkylating agents in the chemotherapy of malignant gliomas. MGMT promoter methylation is considered to be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e226939c7766e252787e93456f403a00
https://www.mdpi.com/1422-0067/22/8/3845
https://www.mdpi.com/1422-0067/22/8/3845
Autor:
Isabel Virchow, Karl Worm, Tanja Trarbach, Winfried Berger, Saskia Ting, Brigitte Schumacher, Tilman Steinmetz, Thomas Höhler, Johannes Meiler, Martin Schuler, Peter Reimer, Gabriele Linden, Stefan Kasper, Thomas Herold, Marcel Wiesweg, Kurt Werner Schmid, Peter Markus, Heike Knipp, Alexander Dechêne, Karina Kostbade, Andreas Paul, Henning Reis
Background The multicenter, single-arm, phase II study CEBIFOX evaluated the efficacy of a biweekly cetuximab administration in combination with FOLFOX6 as first-line therapy in KRAS (exon 2) wild-type (wt) metastatic colorectal cancer (mCRC). Patien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5696b5ebc448e4c4fa8e944cdfb072ca
https://www.ncbi.nlm.nih.gov/pubmed/32737003
https://www.ncbi.nlm.nih.gov/pubmed/32737003
Autor:
Henning Reis, Stefan Kasper, Martin Schuler, Brigitte Schumacher, Alexander Dechêne, Karl Worm, Gregor Zaun, Kurt Werner Schmid, Andreas Paul, Thomas Herold, Moritz Goetz, Nathalie Wolf, Tobias Köster, Peter Markus, Marcel Wiesweg, Karina Kostbade, Martin Metzenmacher, Isabel Virchow
Publikováno v:
Clinical Colorectal Cancer. 17:e331-e352
Deregulation of signal transduction pathways plays a critical role in oncogenesis of colorectal cancer (CRC) and directly affects sensitivity to targeted therapies. Against this background we developed a comprehensive biomarker profiling program incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e78fd6018da4ed5337bd2d7d0d452f
https://doi.org/10.1016/j.clcc.2018.02.003
https://doi.org/10.1016/j.clcc.2018.02.003
Autor:
Kurt Werner Schmid, Frederik Wein, Klaus Lennartz, Karl Worm, Sien-Yi Sheu-Grabellus, Suzan Schwertheim
Publikováno v:
Journal of Cancer Research and Clinical Oncology. 143:1143-1154
The therapy of unresectable advanced thyroid carcinomas shows unfavorable outcome. Constitutive nuclear factor-κB (NF-κB) activation in thyroid carcinomas frequently contributes to therapeutic resistance; the radioiodine therapy often fails due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1072cb2512a22ca54ffd82a7e4333f4
https://doi.org/10.1007/s00432-017-2380-z
https://doi.org/10.1007/s00432-017-2380-z