Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Karl W. Hasel"'
Autor:
J. Gregor Sutcliffe, P. Austin Nelson, Brian S. Hilbush, Karl W. Hasel, Patria E. Danielson, Elizabeth A. Thomas, Thomas M. Pribyl
Publikováno v:
Journal of Neurochemistry. 76:789-796
In contrast to typical neuroleptic drugs, which have high affinities for dopamine D2 receptors, clozapine binds to multiple neurotransmitter receptors. The mechanisms responsible for its superior clinical efficacy over typical neuroleptics remain unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c244196aff0d208ad5f0d34ba6dddfe1
https://doi.org/10.1046/j.1471-4159.2001.00027.x
https://doi.org/10.1046/j.1471-4159.2001.00027.x
Autor:
Monica J. Carson, Karl W. Hasel, Brian S. Hilbush, Lauren N. Sautkulis, J. Gregor Sutcliffe, Christoph D. Schmid, Patria E. Danielson, Judith Cooper
Publikováno v:
Journal of Neurochemistry. 83:1309-1320
Microglial activation is an early and common feature of almost all neuropathologies, including multiple sclerosis, Alzheimer's disease and mechanical injury. To better understand the relative contributions microglia make toward neurodegeneration and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9218a4a60c68113e30928590bc01d87
https://doi.org/10.1046/j.1471-4159.2002.01243.x
https://doi.org/10.1046/j.1471-4159.2002.01243.x
Autor:
Leon J. Bodzin, J T Durham, B S Hilbush, J G Sutcliffe, Mark G. Erlander, Pamela E. Foye, Karl W. Hasel
Publikováno v:
Proceedings of the National Academy of Sciences. 97:1976-1981
We have developed an automated, high-throughput, systematic cDNA display method called TOGA, an acronym for total gene expression analysis. TOGA utilizes 8-nt sequences, comprised of a 4-nt restriction endonuclease cleavage site and adjacent 4-nt par
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2fa4ef3e9027e68faef2e32cc098916
https://doi.org/10.1073/pnas.040537997
https://doi.org/10.1073/pnas.040537997
Autor:
Jianshan Ma, J. C. Norton, J G Sutcliffe, Karl W. Hasel, Gabriel H. Travis, A. C. Allen, J. B. Burns, J. L. Burns
Publikováno v:
Genomics. 28:212-219
Retinal degeneration slow (rds) is a semidominant mutation of mice that causes dysplasia and degeneration of rod and cone photoreceptors. Mutations in RDS, the human ortholog of the rds gene, are responsible for several inherited retinal dystrophies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13721997c91a8dc091818d8f055d9a2a
https://doi.org/10.1006/geno.1995.1133
https://doi.org/10.1006/geno.1995.1133
Publikováno v:
The FASEB Journal. 9:107-114
The crystal structure of anti-idiotopic Fab 409.5.3, made against an E2 specific feline infectious peritonitis virus-neutralizing antibody 730.1.4, has been determined in its free from, at 2.9 A resolution by molecular replacement. This antibody, use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a8003f62cebc9a6e6c65ba2de7f19d
https://doi.org/10.1096/fasebj.9.1.7821749
https://doi.org/10.1096/fasebj.9.1.7821749
Autor:
Aaron Greenwood, John Day, Alexander McPherson, Lisa J. Harris, Karl W. Hasel, Steven B. Larson
Publikováno v:
Nature. 360:369-372
Crystal structures of Fab antibody fragments determined by X-ray diffraction characteristically feature four-domain, beta-barrel arrangements. A human antibody Fc fragment has also been found to have four beta-barrel domains. The structures of a few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e57863e789742d416dbfa5daa28164c5
https://doi.org/10.1038/360369a0
https://doi.org/10.1038/360369a0
Publikováno v:
Molecular and Cellular Biology. 11:3484-3491
Cyclophilin is a ubiquitously expressed cytosolic peptidyl-prolyl cis-trans isomerase that is inhibited by the immunosuppressive drug cyclosporin A. A degenerate oligonucleotide based on a conserved cyclophilin sequence was used to isolate cDNA clone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::230b3b1dc1d5802e739cd7304bd5a591
https://doi.org/10.1128/mcb.11.7.3484
https://doi.org/10.1128/mcb.11.7.3484
Autor:
Winrow Christopher J, Zoë Weaver, Amy J. Warren, David J. Lockhart, Daniel G. Pankratz, Karl W. Hasel, Anthony Wynshaw-Boris, Marie A. Callahan, Carrolee Barlow, T. J. Bowen, Brian S. Hilbush, Cecile Rose T. Vibat
Publikováno v:
Human molecular genetics. 14(18)
Ataxia telangiectasia (A-T) is an autosomal recessive disease caused by loss of function of the serine/ threonine protein kinase ATM (ataxia telangiectasia mutated). A-T patients have a 250-700-fold increased risk of developing lymphomas and leukemia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257ff163d4a3f009067bf3f6ae6fc433
https://pubmed.ncbi.nlm.nih.gov/16087685
https://pubmed.ncbi.nlm.nih.gov/16087685
Autor:
GRAHAM P. ALLAWAY, KAREN L. DAVIS-BRUNO, GARY A. BEAUDRY, ELISA B. GARCIA, EMILY L. WONG, ANDREW M. RYDER, KARL W. HASEL, MARIE-CLAIRE GAUDUIN, RICHARD A. KOUP, J. STEVEN McDOUGAL, PAUL J. MADDON
Publikováno v:
AIDS research and human retroviruses. 11(5)
CD4-IgG2 is a novel fusion protein comprising human IgG2 in which the Fv portions of both heavy and light chains have been replaced by the V1 and V2 domains of human CD4. This tetrameric protein is being developed as an immunoprophylactic agent to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794c4dbc5d86411d551a1484050927b0
https://pubmed.ncbi.nlm.nih.gov/7576908
https://pubmed.ncbi.nlm.nih.gov/7576908
Autor:
Nenad Ban, Robyn Garcia, Carlos Escobar, Karl W. Hasel, Alexander McPherson, Aaron Greenwood, John Day
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 91(5)
Anti-idiotypic monoclonal antibody 409.5.3 is raised against an antibody that neutralizes feline infectious peritonitis virus. This antibody, used as an immunogen, elicits the production of anti-anti-idiotypic antibodies that in turn neutralize the v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1089a9e1fc112f6230b363039bc8d230
https://pubmed.ncbi.nlm.nih.gov/8127852
https://pubmed.ncbi.nlm.nih.gov/8127852