Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Karl W. Aston"'
Autor:
Ann E. Hallinan, Jeffery S. Carter, David G. Brown, John J. Talley, Timothy Maziasz, Karl W. Aston, Bruce C. Hamper, Matthew J. Graneto, Koszyk Francis, Jaime L. Masferrer, Ludwig Cindy L, Jane L. Wang, David C. Limburg
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7164-7168
In this manuscript, we report the discovery of the substituted 2-trifluoromethyl-2H-benzopyran-3-carboxylic acids as a novel series of potent and selective cyclooxygenase-2 (COX-2) inhibitors. We provide the structure–activity relationships, optimi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca972ff580b09dc552a085ce8062ac97
https://doi.org/10.1016/j.bmcl.2010.07.059
https://doi.org/10.1016/j.bmcl.2010.07.059
Synthesis of conformationally tailored pentaazacyclopentadecanes. Preorganizing peptide cyclizations
Autor:
William L. Neumann, Randy H. Weiss, Kirby R. Sample, Dennis P. Riley, Karl W. Aston, Gary W. Franklin
Publikováno v:
Tetrahedron Letters. 38:779-782
A general method for the preparation of rigidified pentaazamacrocycles using trans-(1R,2R)-diaminocyclohexane as the conformational controller element. High macrocyclization yields have been obtained by strategic placement of the diaminocyclohexane g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5bee4280fb1b6f28ffa0f28b55653f4
https://doi.org/10.1016/s0040-4039(96)02446-x
https://doi.org/10.1016/s0040-4039(96)02446-x
Autor:
Randy H. Weiss, Kirby R. Sample, William L. Neumann, Witold Szulbinski, † Chaur-Sun Ling, Patrick J. Lennon, Dennis P. Riley, Willie J. Rivers, Jeng-Jong Shieh, Karl W. Aston, Hayat Rahman, and Daryle H. Busch, Susan L. Henke
Publikováno v:
Inorganic Chemistry. 35:5213-5231
Superoxide radical anion has been demonstrated to be a mediator of many disease states, including inflammatory, autoimmune, and cancerous diseases. As a consequence, we have developed a program to design, synthesize, and test synthetic low-molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::056ffc4cdfadf921ef7fe57c7355a58c
https://doi.org/10.1021/ic960262v
https://doi.org/10.1021/ic960262v
Autor:
Susan L. Henke, William L. Neumann, Randy H. Weiss, Kirby R. Sample, Anil S. Modak, Karl W. Aston, Dennis P. Riley
Publikováno v:
Tetrahedron Letters. 35:3687-3690
A general synthetic method for the preparation of carbon-functionalized polyazamacrocycles from the corresponding cyclic peptides is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51ab00906bbdcb4a88b2ef0ae1c229f3
https://doi.org/10.1016/s0040-4039(00)73072-3
https://doi.org/10.1016/s0040-4039(00)73072-3
Publikováno v:
Tetrahedron Letters. 35:853-856
The synthesis of two new series of conformationally constrained polyazamacrocycles featuring polysubstitution at macrocycle ring carbons is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43696daefd46cf01dad8cf85c1d4041c
https://doi.org/10.1016/s0040-4039(00)75981-8
https://doi.org/10.1016/s0040-4039(00)75981-8
Autor:
Medora M. Hardy, Karl W. Aston, A. G. Flickinger, Una S. Ryan, Willie J. Rivers, Randy H. Weiss, Dennis P. Riley
Publikováno v:
Journal of Biological Chemistry. 268:23049-23054
By stopped-flow kinetic analysis, we have directly evaluated the superoxide dismutase (SOD) activity of a number of organic nitroxides and iron- and manganese-based complexes that have been attributed with having SOD activity based upon competition e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65a85cfc7d53fdc35e7b1c08626aa7a2
https://doi.org/10.1016/s0021-9258(19)49423-4
https://doi.org/10.1016/s0021-9258(19)49423-4
Autor:
Barry L. Parnas, Randy H. Weiss, Richard W. Gross, Stanley L. Hazen, Daniel P. Getman, Karl W. Aston, Patrick J. Lennon, Lori A. Zupan
Publikováno v:
Journal of Medicinal Chemistry. 36:95-100
Haloenol lactones are potent mechanism-based inhibitors of a novel class of calcium-independent phospholipases A2 which have been implicated as the enzymic mediators of membrane dysfunction during myocardial ischemia (Hazen, S. L.; et al. J. Biol. Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e397d9026a25039dc79e818e404d01aa
https://doi.org/10.1021/jm00053a012
https://doi.org/10.1021/jm00053a012
Publikováno v:
ChemInform. 25
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1cb057463faa2c2b35d5618ec72855a
https://doi.org/10.1002/chin.199425160
https://doi.org/10.1002/chin.199425160
Autor:
Nigam P. Rath, Karl W. Aston, Kirby R. Sample, William L. Neumann, Randy H. Weiss, Gary W. Franklin, Dennis P. Riley
Publikováno v:
ChemInform. 28
The synthesis of a bis-cyclohexyl-fused pentaazamacrocycle via head-to-tail pseudopeptide cyclization chemistry is described. The bis-cyclohexyl-fused cyclic pseudopeptide 11 displays intramolecular hydrogen bonding which has been characterized by va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a2f5abfcf4b7ba3cc21aecc4cb1dbb4
https://doi.org/10.1002/chin.199733210
https://doi.org/10.1002/chin.199733210
Autor:
William L. Neumann, Randy H. Weiss, Dennis P. Riley, Kirby R. Sample, Karl W. Aston, Gary W. Franklin
Publikováno v:
ChemInform. 28
A general method for the preparation of rigidified pentaazamacrocycles using trans-(1R,2R)-diaminocyclohexane as the conformational controller element. High macrocyclization yields have been obtained by strategic placement of the diaminocyclohexane g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e9fb68d5207c321a45e1dabfe7f865eb
https://doi.org/10.1002/chin.199722175
https://doi.org/10.1002/chin.199722175