Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Karl W. Ace"'
Autor:
Robert B. Perni, Karl W. Ace, Bruce G. Szczepankiewicz, Ben Hagger, Simon A. Watson, Malcolm B. Berry, Gary Lacking, Ranjit Chima, Toby Broom, Gareth Alford, Andrew Rutter, Paul Evans, Christopher Cunningham, Graeme Marchbank, Mark J. Hughes, John C. Roberts
Publikováno v:
Organic Process Research & Development. 18:1354-1359
A continuous flow process was developed for the synthesis of potassium bromomethyltrifluoroborate, a key precursor for Suzuki–Miyaura coupling reagents. The continuous flow process was used to produce potassium bromomethyltrifluoroborate on scales
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72b26b36142b395dd2b0aa79cc67277b
https://doi.org/10.1021/op400090a
https://doi.org/10.1021/op400090a
Autor:
Herman O. Sintim, John D. Harling, Paul M. Guyo, Timothy J. Donohoe, Karl W. Ace, Leena Sisangia, Andrew R. Cowley
Publikováno v:
Chemistry - A European Journal. 11:4227-4238
A new synthesis of the 20S proteasome inhibitor clasto-lactacystin beta-lactone is described. Our route to this important natural product involves the partial reduction of an electron deficient pyrrole as a key step. By judicious choice of enolate co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34919361a6aa5b26148797f6423b04bd
https://doi.org/10.1002/chem.200401119
https://doi.org/10.1002/chem.200401119
Autor:
Laurence C. Powling, David S. Ennis, David Lathbury, Mark A. Armitage, Paul D. Blackler, Nigel Hussain, Graham H. Oakes, Noah O'Connor, David O. Morgan, Richard K. Bellingham, and Stephen C. Passey, Karl W. Ace
Publikováno v:
Organic Process Research & Development. 5:479-490
A literature route to 1-(2-{4-[(E)-1-(4-iodophenyl)-2-phenyl-but-1-enyl]phenoxy}ethyl)pyrrolidine (idoxifene) has been modified to tackle various scale-up issues and provide initial supplies. A new highly efficient, robust, and stereoselective manufa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f260d40b01d7ee2e398cabc11937c066
https://doi.org/10.1021/op0100394
https://doi.org/10.1021/op0100394
Publikováno v:
Tetrahedron Letters. 36:8141-8144
The α-diazo esters (6) and (7) react, in the absence of any catalyst, with a variety of HONR2 and HONCR2 compounds to give the 0-alkylated adducts (8) to (16). In particular, reaction of (7) with N-hydroxyphthalimide in refluxing benzene followed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d014470f129ad1274b7c97429184b6c3
https://doi.org/10.1016/0040-4039(95)01697-g
https://doi.org/10.1016/0040-4039(95)01697-g
Publikováno v:
ChemInform. 27
The α-diazo esters (6) and (7) react, in the absence of any catalyst, with a variety of HONR2 and HONCR2 compounds to give the 0-alkylated adducts (8) to (16). In particular, reaction of (7) with N-hydroxyphthalimide in refluxing benzene followed by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c7bfd4f9dbb1167f42131b640428954a
https://doi.org/10.1002/chin.199607141
https://doi.org/10.1002/chin.199607141
Publikováno v:
ChemInform. 31
The Birch reduction of both pyrroles and furans can be quenched with an aldehyde electrophile, thus constituting a reductive aldol reaction. Although the reaction was not stereoselective, the pyrrolines derived from reduction of pyrroles could be oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f465a7e914c8c46e7caad86d56b0f7f9
https://doi.org/10.1002/chin.200018084
https://doi.org/10.1002/chin.200018084
Autor:
Karl W. Ace, John D. Sutherland
Publikováno v:
Chemistrybiodiversity. 1(11)
The potentially prebiotic synthesis of pyrimidine ribonucleotides by stepwise nucleobase assembly on arabinose-3-phosphate derivatives has been demonstrated in previous work. The generation of xylose-2-phosphate derivatives by aldolisation, and the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81c021070c3f41f9316e7204442dda48
https://pubmed.ncbi.nlm.nih.gov/17191808
https://pubmed.ncbi.nlm.nih.gov/17191808
Publikováno v:
TETRAHEDRON LETTERS. 41(7)
The Birch reduction of both pyrroles and furans can be quenched with an aldehyde electrophile, thus constituting a reductive aldol reaction. Although the reaction was not stereoselective, the pyrrolines derived from reduction of pyrroles could be oxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29081e98aee1703c57ce45129bf991d
http://ora.ox.ac.uk/objects/uuid:45cdd7bd-8e0f-470e-afde-ba7912c9bc8e
http://ora.ox.ac.uk/objects/uuid:45cdd7bd-8e0f-470e-afde-ba7912c9bc8e
Publikováno v:
Organic & Biomolecular Chemistry. 1:3749
The reductive aldol reaction of electron deficient aromatic compounds has been investigated and found to be a viable method for carbon–carbon bond formation. Reductions under ammonia and ammonia-free conditions were both capable of facilitating the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee59568c42ea9329c7f9115e35c687f5
https://doi.org/10.1039/b306937k
https://doi.org/10.1039/b306937k
Autor:
Timothy J. Donohoe, Herman O. Sintim, Leena Sisangia, Karl W. Ace, Paul M. Guyo, Andrew Cowley, John D. Harling
Publikováno v:
Chemistry - A European Journal; Jun2005, Vol. 11 Issue 14, p4227-4238, 12p