Zobrazeno 1 - 10
of 616
pro vyhledávání: '"Karl T. Kelsey"'
Autor:
Emily Nissen, Alexander Reiner, Simin Liu, Robert B. Wallace, Annette M. Molinaro, Lucas A. Salas, Brock C. Christensen, John K. Wiencke, Devin C. Koestler, Karl T. Kelsey
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-16 (2023)
Abstract Background Over the past decade, DNA methylation (DNAm)-based deconvolution methods that leverage cell-specific DNAm markers of immune cell types have been developed to provide accurate estimates of the proportions of leukocytes in periphera
Externí odkaz:
https://doaj.org/article/208d74f53e1241a0b7e56fbcf8f4dbbb
Autor:
Yifan Xu, Ziqiao Wang, Peng Wei, Richa Gairola, Karl T. Kelsey, Andrew G. Sikora, Guojun Li, Jian Gu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 30, Iss , Pp 596-605 (2022)
The incidence of oropharyngeal squamous cell carcinoma (OPSCC) has increased rapidly in the United States, driven by rising human papillomavirus (HPV) infections in the U.S. population. HPV-positive OPSCC patients have a better prognosis than HPV-neg
Externí odkaz:
https://doaj.org/article/ce1115de010f4b128ef5604551fd3a29
Autor:
Ze Zhang, John K. Wiencke, Karl T. Kelsey, Devin C. Koestler, Brock C. Christensen, Lucas A. Salas
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-17 (2022)
Abstract Background Cellular compositions of solid tumor microenvironments are heterogeneous, varying across patients and tumor types. High-resolution profiling of the tumor microenvironment cell composition is crucial to understanding its biological
Externí odkaz:
https://doaj.org/article/06b0130bd3f842a289f23b1a27017723
Autor:
J. K. Wiencke, Annette M. Molinaro, Gayathri Warrier, Terri Rice, Jennifer Clarke, Jennie W. Taylor, Margaret Wrensch, Helen Hansen, Lucie McCoy, Emily Tang, Stan J. Tamaki, Courtney M. Tamaki, Emily Nissen, Paige Bracci, Lucas A. Salas, Devin C. Koestler, Brock C. Christensen, Ze Zhang, Karl T. Kelsey
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Glucocorticoids, such as dexamethasone, are used as anti-inflammatory and immunosuppressive drugs, however patients may exhibit resistance or side effects. Here the authors propose that a dexamethasone related neutrophil-specific DNA methylation inde
Externí odkaz:
https://doaj.org/article/8c78f67ff3fe480fa4daea5990680400
Autor:
Ze Zhang, John K. Wiencke, Karl T. Kelsey, Devin C. Koestler, Annette M. Molinaro, Steven C. Pike, Prasoona Karra, Brock C. Christensen, Lucas A. Salas
Publikováno v:
Frontiers in Neuroscience, Vol 17 (2023)
IntroductionThe human brain comprises heterogeneous cell types whose composition can be altered with physiological and pathological conditions. New approaches to discern the diversity and distribution of brain cells associated with neurological condi
Externí odkaz:
https://doaj.org/article/10a18efbf4754420ba4472deb6d19ab0
Autor:
Naisi Zhao, Mengyuan Ruan, Devin C. Koestler, Jiayun Lu, Carmen J. Marsit, Karl T. Kelsey, Elizabeth A. Platz, Dominique S. Michaud
Publikováno v:
Epigenetics, Vol 17, Iss 4, Pp 460-472 (2022)
Background: DNA methylation markers have been associated with lung cancer risk and may identify aetiologically relevant genomic regions, or alternatively, be markers of disease risk factors or biological processes associated with disease development.
Externí odkaz:
https://doaj.org/article/26a22d3ddeac421d887ddb2bc5d0527c
Autor:
John K. Wiencke, Ze Zhang, Devin C. Koestler, Lucas A. Salas, Annette M. Molinaro, Brock C. Christensen, Karl T. Kelsey
Publikováno v:
Epigenetics, Vol 17, Iss 3, Pp 335-355 (2022)
The mammalian kidney has extensive repair capacity; however, identifying adult renal stem cells has proven elusive. We applied an epigenetic marker of foetal cell origin (FCO) in diverse human tissues as a probe for developmental cell persistence, fi
Externí odkaz:
https://doaj.org/article/3929b242fa784d08bf5beb8278f5720d
Autor:
Lucas A. Salas, Ze Zhang, Devin C. Koestler, Rondi A. Butler, Helen M. Hansen, Annette M. Molinaro, John K. Wiencke, Karl T. Kelsey, Brock C. Christensen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Deconvolution algorithms facilitate studying cell type-specific changes using bulk data from complex tissues. Here, the authors present a deconvolution method that predicts DNA methylation levels in 12 leukocyte subtypes using human microarray data a
Externí odkaz:
https://doaj.org/article/ccebbe6ed99f41e78e9a2e3097b42b84
Autor:
Mei Chung, Mengyuan Ruan, Naisi Zhao, Devin C. Koestler, Immaculata De Vivo, Karl T. Kelsey, Dominique S. Michaud
Publikováno v:
Epigenetics, Vol 16, Iss 12, Pp 1306-1316 (2021)
DNA methylation (DNAm) age may reflect age-related variations in biological changes and abnormalities related to ageing. DNAm age acceleration measures have been associated with a number of cancers, but to our knowledge, have not been examined in rel
Externí odkaz:
https://doaj.org/article/99addb5db9ac4b5983f8bc5385e70afb
Autor:
Matthew R. Rytel, Rondi Butler, Melissa Eliot, Joseph M. Braun, E. Andres Houseman, Karl T. Kelsey
Publikováno v:
Environmental Health, Vol 20, Iss 1, Pp 1-13 (2021)
Abstract Background Between 1962 and 1971, the US Air Force sprayed Agent Orange across Vietnam, exposing many soldiers to this dioxin-containing herbicide. Several negative health outcomes have been linked to Agent Orange exposure, but data is lacki
Externí odkaz:
https://doaj.org/article/6a2193cf270b4615a7562703e1901b4e