Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Karl T Riabowol"'
Autor:
Arash Nabbi, Urszula L. McClurg, Subhash Thalappilly, Amal Almami, Mahsa Mobahat, Tarek A. Bismar, Olivier Binda, Karl T. Riabowol
Publikováno v:
BMC Medicine, Vol 15, Iss 1, Pp 1-14 (2017)
Abstract Background The androgen receptor (AR) is a major driver of prostate cancer, and increased AR levels and co-activators of the receptor promote the development of prostate cancer. INhibitor of Growth (ING) proteins target lysine acetyltransfer
Externí odkaz:
https://doaj.org/article/545e526d0f004c84aa98ff320fe478e9
Publikováno v:
Aging cell. 4(2)
Telomere length is linked to age-associated diseases, with shorter telomeres in blood associated with an increased probability of mortality from infection or heart disease. Little is known about how human telomere length is regulated despite convinci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::257de55df725da3da669825727cac2b4
https://pubmed.ncbi.nlm.nih.gov/15771613
https://pubmed.ncbi.nlm.nih.gov/15771613
Autor:
Karl T Riabowol, Jason K Quarrie
Publikováno v:
Science of aging knowledge environment : SAGE KE. 2004(31)
Mice are excellent experimental models for genetic research and are being used to investigate the genetic component of organismal aging. Several mutant mice are known to possess defects in the growth hormone/insulin-like growth factor 1 (GH/IGF-1) ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0124fb07464af4f9c8f9addef6ad7b9e
https://pubmed.ncbi.nlm.nih.gov/15295107
https://pubmed.ncbi.nlm.nih.gov/15295107
Publikováno v:
AGE. 8:114-121
Extrachromosomal molecules of covalently closed cirular DNA (cccDNAs) were isolated from human fibroblasts near the end of their in vitro replicative lifespan and cloned into plasmid pBR322. Uncloned cccDNAs varied from several hundred to several tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa8412e7a3b8ab8709f88e2e15e3bb6
https://doi.org/10.1007/bf02431951
https://doi.org/10.1007/bf02431951
Autor:
Samuel Goldstein, Robert J. Shmookler Reis, John R. McGill, Charles K. Lumpkin, Karl T. Riabowol
Publikováno v:
Nature. 301:394-398
A DNA sequence situated in the human genome between Alu-repeat clusters (‘inter-Alu’ DNA) is progressively amplified in extrachromosomal DNA, including covalently closed DNA circles, during serial passage of diploid fibroblasts. A single-size cla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca84f29a7da20397098dfe08c1c460bb
https://doi.org/10.1038/301394a0
https://doi.org/10.1038/301394a0
Publikováno v:
Nucleic Acids Research. 13:5563-5584
Extrachromosomal covalently closed circular DNA (cccDNA) was isolated from human diploid fibroblasts by alkaline denaturation/renaturation and CsCl-ethidium bromide isopycnic centrifugation. Probing across these gradient fractions showed a higher pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b612bdcbebc111674bc7637d1476b40e
https://doi.org/10.1093/nar/13.15.5563
https://doi.org/10.1093/nar/13.15.5563
Publikováno v:
Molecular and cellular biology. 9(10)
Agents that elevate the intracellular concentration of cyclic AMP (cAMP) rapidly and transiently induce expression of the c-fos proto-oncogene in BALB/c 3T3 cells. We show that the mouse c-fos promoter-enhancer region contains multiple elements that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::548cb02e50a0d04c84f405274528d18d
https://pubmed.ncbi.nlm.nih.gov/2555687
https://pubmed.ncbi.nlm.nih.gov/2555687
Transcription of the protooncogene c-fos is increased greater than 10-fold within minutes of treatment of fibroblasts with serum or purified growth factors. Recent experiments with mouse 3T3 cell lines containing inducible fos antisense RNA construct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546f70219d38885cfcd97b48371ce3b3
https://europepmc.org/articles/PMC363327/
https://europepmc.org/articles/PMC363327/
Publikováno v:
Molecular Biology of Aging ISBN: 9781489922205
In this paper we review our recent studies on the human fibroblast model of cellular aging, which illustrate how physiological decline and certain age-dependent diseases may develop at the cellular level. We will demonstrate that the basis of these c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97f37036635a617b7333bcdf44d9df96
https://doi.org/10.1007/978-1-4899-2218-2_16
https://doi.org/10.1007/978-1-4899-2218-2_16
Publikováno v:
Cold Spring Harbor symposia on quantitative biology.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68192d6e8f4636e8e46d8176aeb853c6
https://pubmed.ncbi.nlm.nih.gov/6574863
https://pubmed.ncbi.nlm.nih.gov/6574863