Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Karl T Haelsig"'
Publikováno v:
Angewandte Chemie. 134
indolizidine alkaloids of unusual biosynthetic origin have recently been characterized from several species of fungi within the Pleosporaceae family. Possessing distinct polycyclic architectures with two embedded electron-rich pyrroles as well as rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cbebbb21ac9f5d0e987b1f9d10f1397
https://doi.org/10.1002/ange.202209457
https://doi.org/10.1002/ange.202209457
Publikováno v:
Acc Chem Res
From structure elucidation and biogenesis to synthetic methodology and total synthesis, terpene natural products have profoundly influenced the development of organic chemistry. Moreover, their myriad functional attributes range from fragrance to pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5bdc362e912240ba667302bcb25a690
https://doi.org/10.1021/acs.accounts.0c00055
https://doi.org/10.1021/acs.accounts.0c00055
Publikováno v:
Journal of the American Chemical Society. 142:1206-1210
Curvulamine and related polypyrrole alkaloids represent a fascinating new class of natural products with unprecedented chemical structures, intriguing biological activities, and mysterious biosynthetic origins. Herein we report the first studies towa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2af6a194b214e054360eb830c17da160
https://doi.org/10.1021/jacs.9b12546
https://doi.org/10.1021/jacs.9b12546
Autor:
Kelsey E. Sivick Gauthier, Dana Piovesan, Soonweng Cho, Kenneth V. Lawson, Patrick G. Schweickert, Alejandra Lopez, Suan Liu, Timothy Park, Artur Mailyan, Jeremy T. A. Fournier, Joel W. Beatty, Samuel L. Drew, Jarek Kalisiak, Balint Gal, Guillaume Mata, Zhang Wang, Brandon R. Rosen, Clayton Hardman, Matthaw P. Epplin, Kai Yu, Karl T. Haelsig, Lixia Jin, Elaine Ginn, Jennie Au, Cesar A. Meleza, Joel Tencer, Amber Pham, Hyock J. Kwon, Stephen W. Young, Manmohan Leleti, Jay P. Powers, Matthew J. Walters
Publikováno v:
Molecular Cancer Therapeutics. 20:P206-P206
Cells in the solid tumor microenvironment are frequently exposed to hypoxic conditions, necessitating molecular adaptations for survival. Of particular importance are transcriptional changes mediated by heterodimeric Hypoxia-Inducible Factor (HIF) pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3dcad50485d58db7e77ba50a6a9d4ed2
https://doi.org/10.1158/1535-7163.targ-21-p206
https://doi.org/10.1158/1535-7163.targ-21-p206
Publikováno v:
J Am Chem Soc
Structurally unprecedented antibacterial alkaloids containing multiple electron-rich pyrrole units have recently been isolated from Curvularia sp. and Bipolaris maydis fungi. This article documents the evolution of a synthetic program aimed at access
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2c9fe6e4f2c826c5b6b5e38a54f4b96
https://pubmed.ncbi.nlm.nih.gov/33570388
https://pubmed.ncbi.nlm.nih.gov/33570388
Autor:
Jamie B. Miyamoto, Julia H. Cochran, Karl T. Haelsig, Scott C. Jeffrey, Kim K. Emmerton, Peter D. Senter, Robert P. Lyon, Robert V. Kolakowski, Chris Leiske
Publikováno v:
Angewandte Chemie. 128:8080-8083
A strategy for the conjugation of alcohol-containing payloads to antibodies has been developed and involves the methylene alkoxy carbamate (MAC) self-immolative unit. A series of MAC β-glucuronide model constructs were prepared to evaluate stability
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4105d61c1b82fc6b62d624b50d7286
https://doi.org/10.1002/ange.201601506
https://doi.org/10.1002/ange.201601506
Publikováno v:
Angewandte Chemie. 125:4978-4982
An exo-selective cyclization of enantioenriched trisubstituted allenes is developed in the presence of combined Au/Ag catalyst which allows the asymmetric preparation of cyclic ethers containing a tetrasubstituted stereocenter.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::639973e51ebd217b38724bc6b2de828b
https://doi.org/10.1002/ange.201300174
https://doi.org/10.1002/ange.201300174
Publikováno v:
ChemInform. 44
An exo-selective cyclization of enantioenriched trisubstituted allenes is developed in the presence of combined Au/Ag catalyst which allows the asymmetric preparation of cyclic ethers containing a tetrasubstituted stereocenter.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bacca08bdf6f2bfef8b1b197045625cd
https://doi.org/10.1002/chin.201338096
https://doi.org/10.1002/chin.201338096
Autor:
Xuan, Jun1 (AUTHOR), Machicao, Paulo A.1 (AUTHOR), Haelsig, Karl T.1 (AUTHOR), Maimone, Thomas J.1 (AUTHOR) maimone@berkeley.edu
Publikováno v:
Angewandte Chemie. 9/12/2022, Vol. 134 Issue 37, p1-4. 4p.