Zobrazeno 1 - 10
of 363
pro vyhledávání: '"Karl S Lang"'
Autor:
Hanna Abberger, Matthias Hose, Anne Ninnemann, Christopher Menne, Mareike Eilbrecht, Karl S Lang, Kai Matuschewski, Robert Geffers, Josephine Herz, Jan Buer, Astrid M Westendorf, Wiebke Hansen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011837 (2023)
Neuropilin-1 (Nrp-1) expression on CD8+ T cells has been identified in tumor-infiltrating lymphocytes and in persistent murine gamma-herpes virus infections, where it interferes with the development of long-lived memory T cell responses. In parasitic
Externí odkaz:
https://doaj.org/article/7b59caa70b0d472fb4113dc9f186b875
Autor:
Paul David, Malgorzata Drabczyk-Pluta, Eva Pastille, Torben Knuschke, Tanja Werner, Nadine Honke, Dominik A Megger, Ilseyar Akhmetzyanova, Namir Shaabani, Annette Eyking-Singer, Elke Cario, Olivia Kershaw, Achim D Gruber, Matthias Tenbusch, Kirsten K Dietze, Mirko Trilling, Jia Liu, Dirk Schadendorf, Hendrik Streeck, Karl S Lang, Youhua Xie, Lisa Zimmer, Barbara Sitek, Annette Paschen, Astrid M Westendorf, Ulf Dittmer, Gennadiy Zelinskyy
Publikováno v:
PLoS Pathogens, Vol 16, Iss 3, p e1008340 (2020)
Combination immunotherapy (CIT) is currently applied as a treatment for different cancers and is proposed as a cure strategy for chronic viral infections. Whether such therapies are efficient during an acute infection remains elusive. To address this
Externí odkaz:
https://doaj.org/article/9987cb67515b4dc9a412c66b03e91f68
Autor:
Vikas Duhan, Thamer A Hamdan, Haifeng C Xu, Prashant Shinde, Hilal Bhat, Fanghui Li, Yahya Al-Matary, Dieter Häussinger, Judith Bezgovsek, Sarah-Kim Friedrich, Cornelia Hardt, Philipp A Lang, Karl S Lang
Publikováno v:
PLoS Pathogens, Vol 15, Iss 6, p e1007797 (2019)
During viral infection, tight regulation of CD8+ T-cell functions determines the outcome of the disease. Recently, others and we determined that the natural killer (NK) cells kill hyperproliferative CD8+ T cells in the context of viral infection, but
Externí odkaz:
https://doaj.org/article/bc0e1ae72f5c4a9d8271e174024902fd
Autor:
Denisa Bojkova, Sandra Westhaus, Rui Costa, Lejla Timmer, Nora Funkenberg, Marek Korencak, Hendrik Streeck, Florian Vondran, Ruth Broering, Stefan Heinrichs, Karl S Lang, Sandra Ciesek
Publikováno v:
Cells, Vol 9, Iss 4, p 1003 (2020)
Direct acting antivirals (DAAs) revolutionized the therapy of chronic hepatitis C infection. However, unexpected high recurrence rates of hepatocellular carcinoma (HCC) after DAA treatment became an issue in patients with advanced cirrhosis and fibro
Externí odkaz:
https://doaj.org/article/61dce93ede87435f83fd9adb9337619d
Autor:
Ilseyar Akhmetzyanova, Malgorzata Drabczyk, C Preston Neff, Kathrin Gibbert, Kirsten K Dietze, Tanja Werner, Jia Liu, Lieping Chen, Karl S Lang, Brent E Palmer, Ulf Dittmer, Gennadiy Zelinskyy
Publikováno v:
PLoS Pathogens, Vol 11, Iss 12, p e1005364 (2015)
Externí odkaz:
https://doaj.org/article/06d2444bd35b4024acb725f5f91289f7
Autor:
Ilseyar Akhmetzyanova, Malgorzata Drabczyk, C Preston Neff, Kathrin Gibbert, Kirsten K Dietze, Tanja Werner, Jia Liu, Lieping Chen, Karl S Lang, Brent E Palmer, Ulf Dittmer, Gennadiy Zelinskyy
Publikováno v:
PLoS Pathogens, Vol 11, Iss 10, p e1005224 (2015)
Cytotoxic CD8+ T Lymphocytes (CTL) efficiently control acute virus infections but can become exhausted when a chronic infection develops. Signaling of the inhibitory receptor PD-1 is an important mechanism for the development of virus-specific CD8+ T
Externí odkaz:
https://doaj.org/article/0a9cc906c58e419eb9bfd18863d16ca0
Autor:
Jamshed Warsi, Zohreh Hosseinzadeh, Bernat Elvira, Lisann Pelzl, Ekaterina Shumilina, Dong-Er Zhang, Karl S Lang, Philipp A Lang, Florian Lang
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0129365 (2015)
USP18 (Ubiquitin-like specific protease 18) is an enzyme cleaving ubiquitin from target proteins. USP18 plays a pivotal role in antiviral and antibacterial immune responses. On the other hand, ubiquitination participates in the regulation of several
Externí odkaz:
https://doaj.org/article/f90e6e77cbcc43d1b76693b2c1356d28
Autor:
Nadine Honke, Namir Shaabani, Dong-Er Zhang, George Iliakis, Haifeng C Xu, Dieter Häussinger, Mike Recher, Max Löhning, Philipp A Lang, Karl S Lang
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003650 (2013)
Infection with viruses carrying cross-reactive antigens is associated with break of immunological tolerance and induction of autoimmune disease. Dendritic cells play an important role in this process. However, it remains unclear why autoimmune-tolera
Externí odkaz:
https://doaj.org/article/78af1e8107c046f8840cf3a0445a0b8e
Autor:
Kathrin Gibbert, Jara J Joedicke, Andreas Meryk, Mirko Trilling, Sandra Francois, Janine Duppach, Anke Kraft, Karl S Lang, Ulf Dittmer
Publikováno v:
PLoS Pathogens, Vol 8, Iss 8, p e1002868 (2012)
The innate immune response mediated by cells such as natural killer (NK) cells is critical for the rapid containment of virus replication and spread during acute infection. Here, we show that subtype 11 of the type I interferon (IFN) family greatly p
Externí odkaz:
https://doaj.org/article/8a9c4e555e654d089ea8c3a31ce2cd58
Autor:
Marius Lötscher, Mike Recher, Karl S Lang, Alexander Navarini, Lukas Hunziker, Roger Santimaria, Markus Glatzel, Petra Schwarz, Jürg Böni, Rolf M Zinkernagel
Publikováno v:
PLoS ONE, Vol 2, Iss 11, p e1158 (2007)
The prion protein (PrP) is crucially involved in transmissible spongiform encephalopathies (TSE), but neither its exact role in disease nor its physiological function are known. Here we show for mice, using histological, immunochemical and PCR-based
Externí odkaz:
https://doaj.org/article/1083097775c24fe99dffa8d5120cf6df