Zobrazeno 1 - 10
of 297
pro vyhledávání: '"Karl S, Peggs"'
Autor:
Amy P. Webster, Simone Ecker, Ismail Moghul, Xiaohong Liu, Pawan Dhami, Sarah Marzi, Dirk S. Paul, Michelle Kuxhausen, Stephanie J. Lee, Stephen R. Spellman, Tao Wang, Andrew Feber, Vardhman Rakyan, Karl S. Peggs, Stephan Beck
Publikováno v:
Frontiers in Genetics, Vol 15 (2024)
Allogeneic hematopoietic cell transplantation (HCT) is used to treat many blood-based disorders and malignancies, however it can also result in serious adverse events, such as the development of acute graft-versus-host disease (aGVHD). This study aim
Externí odkaz:
https://doaj.org/article/951e2cf5b5514896b6ba6afd2a1f92db
Autor:
Harry Dolstra, Claire Roddie, Martin A Pule, Vedika Mehra, Giulia Agliardi, Juliana Dias Alves Pinto, Manar S Shafat, Amaia Cadinanos Garai, Louisa Green, Alastair Hotblack, Fred Arce Vargas, Karl S Peggs, Anniek B van der Waart
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 9 (2023)
Background AUTO1 is a fast off-rate CD19-targeting chimeric antigen receptor (CAR), which has been successfully tested in adult lymphoblastic leukemia. Tscm/Tcm-enriched CAR-T populations confer the best expansion and persistence, but Tscm/Tcm number
Externí odkaz:
https://doaj.org/article/304fa86b5512400a84f30e4d82b38677
Autor:
Strachan Mackenzie, Manar Shafat, Harriet Roddy, Harpreet Hyare, Lorna Neill, Maria A. V. Marzolini, Michael Gilhooley, Teresa Marafioti, Eleanna Kara, Emilie Sanchez, Jeremy Rees, David S. Lynch, Kirsty Thomson, Kirit M. Ardeshna, Arian Laurence, Karl S. Peggs, Maeve O'Reilly, Claire Roddie
Publikováno v:
eJHaem, Vol 2, Iss 4, Pp 848-853 (2021)
Abstract Progressive multifocal leukoencephalopathy (PML) is an opportunistic brain infection with few treatment options and poor survival when reversal of the underlying immune dysfunction is not achievable. JC polyomavirus reactivation resulting in
Externí odkaz:
https://doaj.org/article/c0d674bf81494667b74ab208dbb6c5eb
Autor:
Emma Das-Gupta, Kirsty J. Thomson, Adrian J.C. Bloor, Andrew D. Clark, Stephen Mackinnon, Irfan Kayani, Laura Clifton-Hadley, Pip Patrick, Nadjet El-Mehidi, Anthony Lawrie, Amy A. Kirkwood, Nigel H. Russell, David C. Linch, Karl S. Peggs
Publikováno v:
Blood Advances, Vol 3, Iss 24, Pp 4264-4270 (2019)
Abstract: We evaluated the role of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in transplant-naïve patients with relapsed/refractory Hodgkin lymphoma (HL) who failed to attain metabolic complete response (mCR) to 1 to 2 lines of s
Externí odkaz:
https://doaj.org/article/fcbef3681889418ebbc0e8a61fd4114f
Publikováno v:
eJHaem, Vol 3, Iss 1, Pp 245-246 (2022)
Externí odkaz:
https://doaj.org/article/e5a487efc2624690a15408f179c66608
Autor:
Karl S. Peggs, Sarah J. Albon, Macarena Oporto Espuelas, Catherine Irving, Rachel Richardson, Joan Casanovas-Company, Rebecca Wallace, Aleks Guvenel, Sara Ghorashian, Angela Collura, Meera Subramaniyam, Barry Flutter, Bilyana Popova, Fernanda Castro, Andre Lopes, Kim Champion, Oliver Schofield, Laura Clifton-Hadley, Thomas Taylor, Maria Farrell, Stuart Adams, Kimberly C. Gilmour, Stephen Mackinnon, Eleni Tholouli, Persis J. Amrolia
Publikováno v:
Cytotherapy. 25:82-93
Delayed immune reconstitution is a major challenge after matched unrelated donor (MUD) stem cell transplant (SCT). In this randomized phase 2 multi-center trial, Adoptive Immunotherapy with CD25/71 allodepleted donor T cells to improve immunity after
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22853e7e3a66fb0693366f4cdaa363f2
https://doi.org/10.1016/j.jcyt.2022.08.010
https://doi.org/10.1016/j.jcyt.2022.08.010
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Cytomegalovirus (CMV) infection is common following allogeneic hematopoietic stem cell transplant (HSCT) and is a major cause of morbidity and increased mortality. Whilst pharmacotherapy can be effective in the prevention and treatment of CMV, these
Externí odkaz:
https://doaj.org/article/f9d6a219272a45fcb1f7cae199778889
Autor:
Karl S. Peggs
Publikováno v:
Blood Advances, Vol 2, Iss 7, Pp 817-820 (2018)
Externí odkaz:
https://doaj.org/article/8a1fdd43f83140a39f0e758cd95fefa1
Autor:
Maria M. Cuadrado, Richard M. Szydlo, Mike Watts, Nishil Patel, Hanna Renshaw, Jude Dorman, Mark Lowdell, Stuart Ings, Chloe Anthias, Alejandro Madrigal, Stephen Mackinnon, Panagiotis Kottaridis, Ben Carpenter, Rachael Hough, Emma Morris, Kirsty Thomson, Karl S. Peggs, Ronjon Chakraverty
Publikováno v:
Haematologica, Vol 105, Iss 11 (2019)
Poor graft function is a serious complication following allogeneic hematopoietic stem cell transplantation. Infusion of CD34+-selected stem cells without pre-conditioning has been used to correct poor graft function, but predictors of recovery are un
Externí odkaz:
https://doaj.org/article/e4c71e8fe9b44e8a8fab72731ed805f0
Autor:
Sergio A. Quezada, Karl S. Peggs, Javier Herrero, Martin Pule, Laurent Poirot, Julianne Smith, Frederick Arce Vargas, Katharina Bergerhoff, Anna Sledzinska, Laurie Menger
PD-1-TALEN activity screen in murine thymoma EL4 cells.PD-1 gene inactivation in pmel-1 CD8+T cells and functional analysis. PD-1-TALEN activity in TRL from MCA205. Effector/memory phenotype of TRL from MCA205.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::330b1d71f398947b2b453e000f8a8721
https://doi.org/10.1158/0008-5472.22413017
https://doi.org/10.1158/0008-5472.22413017
