Zobrazeno 1 - 10
of 338
pro vyhledávání: '"Karl S, Lang"'
Autor:
Paweł Stachura, Wei Liu, Haifeng C. Xu, Agnès Wlodarczyk, Olivia Stencel, Piyush Pandey, Melina Vogt, Sanil Bhatia, Daniel Picard, Marc Remke, Karl S. Lang, Dieter Häussinger, Bernhard Homey, Philipp A. Lang, Arndt Borkhardt, Aleksandra A. Pandyra
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-20 (2023)
Abstract Background New therapies are urgently needed in melanoma, particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors. To uncover novel potentiators of T cell anti-tumor immunity, we carried out an ex vivo pha
Externí odkaz:
https://doaj.org/article/f770cd12a72b4c18be56dafec7315fc0
Autor:
Hanna Abberger, Matthias Hose, Anne Ninnemann, Christopher Menne, Mareike Eilbrecht, Karl S Lang, Kai Matuschewski, Robert Geffers, Josephine Herz, Jan Buer, Astrid M Westendorf, Wiebke Hansen
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011837 (2023)
Neuropilin-1 (Nrp-1) expression on CD8+ T cells has been identified in tumor-infiltrating lymphocytes and in persistent murine gamma-herpes virus infections, where it interferes with the development of long-lived memory T cell responses. In parasitic
Externí odkaz:
https://doaj.org/article/7b59caa70b0d472fb4113dc9f186b875
Autor:
Haifeng C. Xu, Jun Huang, Aleksandra A. Pandyra, Piyush Pandey, Ruifeng Wang, Zeli Zhang, Yuan Zhuang, Christoph G.W. Gertzen, Carsten Münk, Diran Herebian, Arndt Borkhardt, Mike Recher, Holger Gohlke, Irene Esposito, Martin Oberbarnscheidt, Dieter Häussinger, Karl S. Lang, Philipp A. Lang
Publikováno v:
Hepatology Communications, Vol 6, Iss 7, Pp 1620-1633 (2022)
Major histocompatibility complex I (MHC‐I) molecules present epitopes on the cellular surface of antigen‐presenting cells to prime cytotoxic clusters of differentiation 8 (CD8)+ T cells (CTLs), which then identify and eliminate other cells such a
Externí odkaz:
https://doaj.org/article/162c721aae254ca7b08f8550afa6f30a
Autor:
Phyllis F. Cheung, JiaJin Yang, Rui Fang, Arianna Borgers, Kirsten Krengel, Anne Stoffel, Kristina Althoff, Chi Wai Yip, Elaine H. L. Siu, Linda W. C. Ng, Karl S. Lang, Lamin B. Cham, Daniel R. Engel, Camille Soun, Igor Cima, Björn Scheffler, Jana K. Striefler, Marianne Sinn, Marcus Bahra, Uwe Pelzer, Helmut Oettle, Peter Markus, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Konstantinos Savvatakis, Sven-Thorsten Liffers, Smiths S. Lueong, Christian Neander, Anna Bazarna, Xin Zhang, Annette Paschen, Howard C. Crawford, Anthony W. H. Chan, Siu Tim Cheung, Jens T. Siveke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation o
Externí odkaz:
https://doaj.org/article/c9aa189db2194c2eba13f30f461a6fdd
Autor:
Haifeng C. Xu, Ruifeng Wang, Prashant V. Shinde, Lara Walotka, Anfei Huang, Gereon Poschmann, Jun Huang, Wei Liu, Kai Stühler, Heiner Schaal, Andreas Bergthaler, Aleksandra A. Pandyra, Cornelia Hardt, Karl S. Lang, Philipp A. Lang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as
Externí odkaz:
https://doaj.org/article/e64f13b539b04accba130bd3d10b5844
Autor:
Julia Zöller, Jana-Fabienne Ebel, Vishal Khairnar, Verena Schmitt, Robert Klopfleisch, Jana Meiners, Virginia Seiffart, Wiebke Hansen, Jan Buer, Bernhard B. Singer, Karl S. Lang, Astrid M. Westendorf
Publikováno v:
Gut Microbes, Vol 11, Iss 6, Pp 1790-1805 (2020)
The incidence of gastrointestinal infections continues to increase, and infectious colitis contributes significantly to morbidity and mortality worldwide. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been discovered to be s
Externí odkaz:
https://doaj.org/article/ff034aef2bb14218ab6925a441b6330f
Autor:
Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer, Burkhard Kleuser, Eduard B. Babiychuk, Beate Sodeik, Jürgen Seibel, Urs F. Greber, Philipp A. Lang, Erich Gulbins, Karl S. Lang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
Externí odkaz:
https://doaj.org/article/ce87beeac86246829e4b47c4ed971f39
Autor:
Wei Liu, Paweł Stachura, Haifeng C. Xu, Nikkitha Umesh Ganesh, Fiona Cox, Ruifeng Wang, Karl S. Lang, Jay Gopalakrishnan, Dieter Häussinger, Bernhard Homey, Philipp A. Lang, Aleksandra A. Pandyra
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-16 (2020)
Abstract Background New therapies are urgently needed in melanoma particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors. Methods Drug screening, IC50 determinations as well as synergy assays were detected by the
Externí odkaz:
https://doaj.org/article/4e58bc7a3f57475c980c5ecf84365c51
Autor:
Vikas Duhan, Vishal Khairnar, Simo Kitanovski, Thamer A. Hamdan, Andrés D. Klein, Judith Lang, Murtaza Ali, Tom Adomati, Hilal Bhat, Sarah-Kim Friedrich, Fanghui Li, Philippe Krebs, Anthony H. Futerman, Marylyn M. Addo, Cornelia Hardt, Daniel Hoffmann, Philipp A. Lang, Karl S. Lang
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide associ
Externí odkaz:
https://doaj.org/article/49106a4d1a9d447db837fc95b1d9fd9c
Autor:
Hilal Bhat, Gregor Zaun, Thamer A. Hamdan, Judith Lang, Tom Adomati, Rosa Schmitz, Sarah-Kim Friedrich, Michael Bergerhausen, Lamin B. Cham, Fanghui Li, Murtaza Ali, Fan Zhou, Vishal Khairnar, Vikas Duhan, Tim Brandenburg, Yara Maria Machlah, Maximilian Schiller, Arshia Berry, Haifeng Xu, Jörg Vollmer, Dieter Häussinger, Beatrice Thier, Aleksandra A. Pandyra, Dirk Schadendorf, Annette Paschen, Martin Schuler, Philipp A. Lang, Karl S. Lang
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Immune activation within the tumor microenvironment is one promising approach to induce tumor regression. Certain viruses including oncolytic viruses such as the herpes simplex virus (HSV) and non-oncolytic viruses such as the lymphocytic choriomenin
Externí odkaz:
https://doaj.org/article/75601dc4b0134284b6d488ec8fac6ac6