Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Karl Ploessl"'
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 9, Iss 1, Pp 1-17 (2024)
Abstract Background Recent advancements in positron emission tomograph (PET) using prostate specific membrane antigen (PSMA)-targeted radiopharmaceuticals have changed the standard of care for prostate cancer patients by providing more accurate infor
Externí odkaz:
https://doaj.org/article/c68203cee7834f80a54764d3e4f6a5e3
Autor:
Haiyan Hong, Zhihao Zha, Ruiyue Zhao, Yang Luo, Wenbin Jin, Linlin Li, Ran Wang, Li Yan, Hui Wang, Karl Ploessl, Jinping Qiao, Lin Zhu, Hank F. Kung
Publikováno v:
Molecular Pharmaceutics. 20:2159-2169
Autor:
Zhihao Zha, Seok Rye Choi, Linlin Li, Ruiyue Zhao, Karl Ploessl, Xinyue Yao, David Alexoff, Lin Zhu, Hank F. Kung
Publikováno v:
Journal of Medicinal Chemistry. 65:13001-13012
Prostate-specific membrane antigen (PSMA) is a promising target for the diagnosis and radionuclide therapy of prostate cancer. This study reports conversion of a previously reported
Autor:
David A. Mankoff, Robert H. Mach, Hank F. Kung, Hsiaoju Lee, Eric Blankemeyer, Hoon Choi, Karl Ploessl, Brian P. Lieberman, Shihong Li, Austin R. Pantel, Rong Zhou
Supplemental Methods. SI-Fig 1 HPLC chromatogram of [18F]4F-Glu and [18F]4F-Gln mixture. SI-Fig 2 Comparison of T/B values obtained by two readers. SI-Fig 3 Comparison of T/B ratios obtained from different tumor ROI methods. SI-Fig 4 Comparison of T/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35458ae9c2e5779cff4fce0e60127565
https://doi.org/10.1158/0008-5472.22416504
https://doi.org/10.1158/0008-5472.22416504
Autor:
David A. Mankoff, Robert H. Mach, Hank F. Kung, Hsiaoju Lee, Eric Blankemeyer, Hoon Choi, Karl Ploessl, Brian P. Lieberman, Shihong Li, Austin R. Pantel, Rong Zhou
Glutaminolysis is a metabolic pathway adapted by many aggressive cancers, including triple-negative breast cancers (TNBC), to utilize glutamine for survival and growth. In this study, we examined the utility of [18F](2S,4R)4-fluoroglutamine ([18F]4F-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0272970429b925dd792fc11d9c8b2520
https://doi.org/10.1158/0008-5472.c.6509568.v1
https://doi.org/10.1158/0008-5472.c.6509568.v1
Kit-based preparation of [68Ga]Ga-P16-093 (PSMA-093) using different commercial 68Ge/68Ga generators
Autor:
Haiyan Hong, Guochang Wang, Karl Ploessl, Zhihao Zha, Jie Zang, Zhaohui Zhu, Lin Zhu, Hank F. Kung
Publikováno v:
Nuclear Medicine and Biology. :1-9
Radiolabeling Optimization and Preclinical Evaluation of the New PSMA Imaging Agent [18F]AlF-P16-093
Publikováno v:
Bioconjugate Chemistry. 32:1017-1026
Prostate-specific membrane antigen (PSMA)-targeted radioligands have played an increasing role in the diagnosis of prostate cancer. [68Ga]Ga-P16-093 is a PSMA-targeting agent for positron emission tomography imaging, currently under a Phase 2 clinica
Publikováno v:
Nuclear Medicine and Biology. 92:97-106
Introduction Since the approval of three 18F labeled β-amyloid-targeting PET imaging agents, Amyvid (florbetapir f18, AV-45), Neuraceq (florbetaben f18, AV-1) and Vizamyl (flutemetamol f18, F-PIB), they have increasingly been employed to assist diff
Publikováno v:
Molecular Pharmaceutics. 17:4589-4602
Prostate-specific membrane antigen (PSMA) is overexpressed in prostate cancer cells and therefore is an attractive target for prostate cancer diagnosis and radionuclide therapy. Recently, published results from clinical studies using a new PSMA-targe
Autor:
Kyle J. Labban, Karl Ploessl, Janet S. Reddin, Robert K. Doot, Erin K. Schubert, Hank F. Kung, Seok Rye Choi, David Alexoff, Hsiaoju Lee, Lin Zhu, Hwan Lee, Daniel A. Pryma, Zhihao Zha, Margaret E. Daube-Witherspoon, Zehui Wu, Joel S. Karp, Anthony J. Young
Publikováno v:
Nucl Med Biol
INTRODUCTION: [(68)Ga]Ga-P15-041 ([(68)Ga]Ga-HBED-CC-BP) is a novel bone-seeking PET radiotracer that can be generator-produced. We undertook a Phase 0/I clinical trial to assess its potential for imaging bone metastases in prostate cancer including