Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Karl Peter Giese"'
Autor:
Mark F. Bear, Sam F. Cooke, Karl Peter Giese, Bong-Kiun Kaang, Mary B. Kennedy, Ji-il Kim, Richard G. M. Morris, Pojeong Park
Publikováno v:
Molecular Brain, Vol 11, Iss 1, Pp 1-12 (2018)
Abstract Shortly before he died in October 2017, John Lisman submitted an invited review to Molecular Brain on ‘Criteria for identifying the molecular basis of the engram (CaMKII, PKMζ)’. John had no opportunity to read the referees’ comments,
Externí odkaz:
https://doaj.org/article/99a1e4f246f645e781b82540df3836dc
Autor:
Fabio Antonio Vigil, Keiko Mizuno, Walter Lucchesi, Victoria Valls-Comamala, Karl Peter Giese
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract CaMK2N1 and CaMK2N2 are endogenous inhibitors of calcium/calmodulin-dependent protein kinase II (CaMKII), a key synaptic signaling molecule for learning and memory. Here, we investigated the learning and memory function of CaMK2N1 by knockin
Externí odkaz:
https://doaj.org/article/bc2e7ec7e3ff46f7aa216e6251ca56ce
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140821 (2015)
p35 is an activation subunit of the cyclin-dependent kinase 5 (CDK5), which is a Ser/Thr kinase that is expressed predominantly in neurons. Disruption of the CDK5 or p35 (CDK5R1) genes induces abnormal neuronal layering in various regions of the mous
Externí odkaz:
https://doaj.org/article/60615799690c4e5f9b0e42d08152791d
Autor:
Keiko Mizuno, Karl Peter Giese
Publikováno v:
Journal of Pharmacological Sciences, Vol 98, Iss 3, Pp 191-197 (2005)
Long-term memory (LTM) formation requires gene transcription and de novo protein synthesis. The transcription factor CREB is required for hippocampus-dependent LTM formation, and it is activated by several signaling pathways, including protein kinase
Externí odkaz:
https://doaj.org/article/d69ee800d61e4e38bff457c47d2cb7cc
Autor:
Karl Peter Giese
Memory Mechanisms is an edited review volume that summarizes state-of-the-art knowledge on memory mechanisms at the molecular, cellular and circuit level. Each review is written by leading experts in the field, presenting not only current knowledge,
Autor:
Emily E Groves, Katherine Sung, Diana Flores‐Dominguez, Saskia J Pollack, Cara L Croft, Todd E Golde, Diane P Hanger, Robyn McAdam, Karl Peter Giese, Wendy Noble
Publikováno v:
Alzheimer's & Dementia. 18
Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer’s disease
Autor:
Huzefa Rupawala, Keshvi Shah, Caitlin Davies, Jamie Rose, Marti Colom-Cadena, Xianhui Peng, Lucy Granat, Manal Aljuhani, Keiko Mizuno, Claire Troakes, Beatriz Gomez Perez-Nievas, Alan Morgan, Po-Wah So, Tibor Hortobagyi, Tara L Spires-Jones, Wendy Noble, Karl Peter Giese
Publikováno v:
Rupawala, H, Shah, K, Davies, C, Rose, J, Colom-Cadena, M, Peng, X, Granat, L, Aljuhani, M, Mizuno, K, Troakes, C, Perez-Nievas, B G, Morgan, A, So, P-W, Hortobagyi, T, Spires-Jones, T L, Noble, W & Giese, K P 2022, ' Cysteine string protein alpha accumulates with early pre-synaptic dysfunction in Alzheimer's disease ', Brain Communications, vol. 4, no. 4, fcac192, pp. fcac192 . https://doi.org/10.1093/braincomms/fcac192
Brain communications
Brain communications
In Alzheimer’s disease, synapse loss causes memory and cognitive impairment. However, the mechanisms underlying synaptic degeneration in Alzheimer’s disease are not well understood. In the hippocampus, alterations in the level of cysteine string
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1c969cb1de3bf9724f960761798cc4c
Autor:
M. S. Shetty, Ethan Bahl, Snehajyoti Chatterjee, J. D. Lederman, A. L. Yan, Jacob J. Michaelson, E. N. Walsh, Karl Peter Giese, Ted Abel, U. Mukherjee, Y. Vanrobaeys
The mechanisms underlying memory loss associated with Alzheimer’s disease and related dementias (ADRD) remain unclear, and no effective treatments exist. Fundamental studies have shown that a set of transcriptional regulatory proteins of the nuclea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6885839efe03bd1b2c90ce6d47337d2d
https://doi.org/10.1101/2021.10.20.465191
https://doi.org/10.1101/2021.10.20.465191
Publikováno v:
Neuropharmacology. 207:108962
Autor:
Chang-Gyu Hahn, Cédrick Florian, Anamika Banerjee, Shane G. Poplawski, Joshua D. Hawk, Camille Lejards, Karl Peter Giese, Giulia S. Porcari, Robbert Havekes, Nelson Spruston, Hannah Schoch, Ted Abel, Morgan S. Bridi
Publikováno v:
JCI Insight, 5(5):92385. AMER SOC CLINICAL INVESTIGATION INC
Long-term memory depends on the control of activity-dependent neuronal gene expression, which is regulated by epigenetic modifications. The epigenetic modification of histones is orchestrated by the opposing activities of 2 classes of regulatory comp