Zobrazeno 1 - 10 of 32 pro vyhledávání: '"Karl P. Nightingale"'
1
Developing the inclusive curriculum: Is supplementary lecture recording an effective approach in supporting students with Specific Learning Difficulties (SpLDs)?
Autor: Vikki Anderson, Helen Davies, Qulsom Fazil, Susan Onens, Karl P. Nightingale
Publikováno v: Computers & Education. 130:13-25
Supplementary lecture capture is widely used in higher education as the recordings generated are highly valued by students. Here we used a between-subjects, mixed methods study to evaluate whether this approach can support the learning of students di
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::352c48a64becb911015fa0e232ea78ad
https://doi.org/10.1016/j.compedu.2018.11.006
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2
Akademický článek
Genes are often sheltered from the global histone hyperacetylation induced by HDAC inhibitors.
Autor: John Halsall, Vibhor Gupta, Laura P O'Neill, Bryan M Turner, Karl P Nightingale
Publikováno v: PLoS ONE, Vol 7, Iss 3, p e33453 (2012)
Histone deacetylase inhibitors (HDACi) are increasingly used as therapeutic agents, but the mechanisms by which they alter cell behaviour remain unclear. Here we use microarray expression analysis to show that only a small proportion of genes (∼9%)
Externí odkaz: https://doaj.org/article/807e277a158b4988a06929a0a365d703
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3
Evaluating the use and impact of lecture recording in undergraduates: Evidence for distinct approaches by different groups of students
Autor: Karl P. Nightingale, Tom Shuttleworth, John Couperthwaite, Wendy Leadbeater
Publikováno v: Computers & Education. 61:185-192
Lecture recordings are increasingly used to supplement lecture attendance within higher education, but their impact on student learning remains unclear. Here we describe a study to evaluate student use of lecture recordings and quantify their impact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb5f02baf782c394a3a831c9a5fb4762
https://doi.org/10.1016/j.compedu.2012.09.011
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4
Protein kinase Msk1 physically and functionally interacts with the KMT2A/MLL1 methyltransferase complex and contributes to the regulation of multiple target genes
Autor: Maaike, Wiersma, Marianne, Bussiere, John A, Halsall, Nil, Turan, Robert, Slany, Bryan M, Turner, Karl P, Nightingale
Publikováno v: Epigenetics & Chromatin
Background The KMT2A/MLL1 lysine methyltransferase complex is an epigenetic regulator of selected developmental genes, in part through the SET domain-catalysed methylation of H3K4. It is essential for normal embryonic development and haematopoiesis a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ae83901b222a6a5ce02215eaeaebc59a
https://pubmed.ncbi.nlm.nih.gov/27895715
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6
Directed evolution of a histone acetyltransferase - enhancing thermostability, whilst maintaining catalytic activity and substrate specificity
Autor: Florian Hollfelder, Hans Leemhuis, Karl P. Nightingale
Publikováno v: FEBS Journal. 275:5635-5647
Histone acetylation plays an integral role in the epigenetic regulation of gene expression. Transcriptional activity reflects the recruitment of opposing classes of enzymes to promoter elements; histone acetyltransferases (EC 2.3.1.48) that deposit a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::250c649b4ae82fb5a76eb66ec7b01a88
https://doi.org/10.1111/j.1742-4658.2008.06689.x
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8
Acetylation increases access of remodelling complexes to their nucleosome targets to enhance initiation of V(D)J recombination
Autor: Karl P. Nightingale, Adamantios Mamais, Matthias Baumann, Peter B. Becker, Joan Boyes, Anton Eberharter
Publikováno v: Nucleic Acids Research
Targeted chromatin remodelling is essential for many nuclear processes, including the regulation of V(D)J recombination. ATP-dependent nucleosome remodelling complexes are important players in this process whose activity must be tightly regulated. We
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f42074cdd4fe442255a18d387ef57f19
https://doi.org/10.1093/nar/gkm650
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9
Cross-talk between Histone Modifications in Response to Histone Deacetylase Inhibitors
Autor: Susanne Gendreizig, Florian Hollfelder, Charlotte Bradbury, Darren A. White, Bryan M. Turner, Karl P. Nightingale
Publikováno v: Journal of Biological Chemistry. 282:4408-4416
Histones are subject to a wide variety of post-translational modifications that play a central role in gene activation and silencing. We have used histone modification-specific antibodies to demonstrate that two histone modifications involved in gene
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0bcc652ac71825ea8c5ff487489e426b
https://doi.org/10.1074/jbc.m606773200
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10
Epigenetics – What it is and Why it Matters
Autor: Karl P. Nightingale
Publikováno v: Epigenetics for Drug Discovery ISBN: 9781849738828
Over the last decade there has been a revolution in our understanding of gene regulation, and how patterns of gene expression are established and maintained in eukaryotic cells. We now know that many factors – including the chemical modification of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::01d5645b0240a6fd1b889b7158a42351
https://doi.org/10.1039/9781782628484-00001
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