Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Karl P. Hodel"'
Autor:
Uri Tabori, Zachary F. Pursell, Cynthia J. Guidos, Cynthia E. Hawkins, James G. Jackson, Zucai Suo, Eric Bouffet, Adam Shlien, Alberto Martin, Carol Durno, Oz Mordechai, Jonathan N. Byrd, Gavin P. Dunn, Tomasz Sarosiek, Andrea Seeley, Jagadeesh Ramdas, Xia Wang, Melyssa Aronson, Nuno M. Nunes, Victoria J. Forster, Jiil Chung, Dana Elshaer, Richard de Borja, Melissa Edwards, Robert Siddaway, Iram Siddiqui, Lazar Joksimovic, Ayse B. Ercan, Vivian S. Park, Nathan A. Ungerleider, Walter J. Zahurancik, Taylor Bridge, Sumedha Sudhaman, Miki S. Gams, Karl P. Hodel, Melissa A. Galati
Supplementary Figure S1 (related to Figure 1): PoleP286R mouse model design, validation, and tumor findings. Supplementary Figure S2 (related to Figure 1): PoleS459F mouse model design, validation, and tumor findings. Supplementary Figure S3 (related
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be86ccbe1dd1695c7f2fa2cfc56c0fe6
https://doi.org/10.1158/0008-5472.22427518.v1
https://doi.org/10.1158/0008-5472.22427518.v1
Autor:
Uri Tabori, Zachary F. Pursell, Cynthia J. Guidos, Cynthia E. Hawkins, James G. Jackson, Zucai Suo, Eric Bouffet, Adam Shlien, Alberto Martin, Carol Durno, Oz Mordechai, Jonathan N. Byrd, Gavin P. Dunn, Tomasz Sarosiek, Andrea Seeley, Jagadeesh Ramdas, Xia Wang, Melyssa Aronson, Nuno M. Nunes, Victoria J. Forster, Jiil Chung, Dana Elshaer, Richard de Borja, Melissa Edwards, Robert Siddaway, Iram Siddiqui, Lazar Joksimovic, Ayse B. Ercan, Vivian S. Park, Nathan A. Ungerleider, Walter J. Zahurancik, Taylor Bridge, Sumedha Sudhaman, Miki S. Gams, Karl P. Hodel, Melissa A. Galati
POLE mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype–phenotype correlation, and therapeutic considerations. In this study, we establish mouse models harboring cancer-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b21c938f653fba762197235f84abd90d
https://doi.org/10.1158/0008-5472.c.6512707.v1
https://doi.org/10.1158/0008-5472.c.6512707.v1
Autor:
Uri Tabori, Zachary F. Pursell, Cynthia J. Guidos, Cynthia E. Hawkins, James G. Jackson, Zucai Suo, Eric Bouffet, Adam Shlien, Alberto Martin, Carol Durno, Oz Mordechai, Jonathan N. Byrd, Gavin P. Dunn, Tomasz Sarosiek, Andrea Seeley, Jagadeesh Ramdas, Xia Wang, Melyssa Aronson, Nuno M. Nunes, Victoria J. Forster, Jiil Chung, Dana Elshaer, Richard de Borja, Melissa Edwards, Robert Siddaway, Iram Siddiqui, Lazar Joksimovic, Ayse B. Ercan, Vivian S. Park, Nathan A. Ungerleider, Walter J. Zahurancik, Taylor Bridge, Sumedha Sudhaman, Miki S. Gams, Karl P. Hodel, Melissa A. Galati
CyTOF panel antibodies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7302cb13b127ac54bae952f0f0eb418a
https://doi.org/10.1158/0008-5472.22427512
https://doi.org/10.1158/0008-5472.22427512
Autor:
Uri Tabori, Zachary F. Pursell, Cynthia J. Guidos, Cynthia E. Hawkins, James G. Jackson, Zucai Suo, Eric Bouffet, Adam Shlien, Alberto Martin, Carol Durno, Oz Mordechai, Jonathan N. Byrd, Gavin P. Dunn, Tomasz Sarosiek, Andrea Seeley, Jagadeesh Ramdas, Xia Wang, Melyssa Aronson, Nuno M. Nunes, Victoria J. Forster, Jiil Chung, Dana Elshaer, Richard de Borja, Melissa Edwards, Robert Siddaway, Iram Siddiqui, Lazar Joksimovic, Ayse B. Ercan, Vivian S. Park, Nathan A. Ungerleider, Walter J. Zahurancik, Taylor Bridge, Sumedha Sudhaman, Miki S. Gams, Karl P. Hodel, Melissa A. Galati
Supplemental Titles and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fed73302977c2511b68fd4a2c7a1b84
https://doi.org/10.1158/0008-5472.22427515
https://doi.org/10.1158/0008-5472.22427515
Autor:
Karl P Hodel, Richard de Borja, Erin E Henninger, Brittany B Campbell, Nathan Ungerleider, Nicholas Light, Tong Wu, Kimberly G LeCompte, A Yasemin Goksenin, Bruce A Bunnell, Uri Tabori, Adam Shlien, Zachary F Pursell
Publikováno v:
eLife, Vol 7 (2018)
Tumors defective for DNA polymerase (Pol) ε proofreading have the highest tumor mutation burden identified. A major unanswered question is whether loss of Pol ε proofreading by itself is sufficient to drive this mutagenesis, or whether additional f
Externí odkaz:
https://doaj.org/article/b21959d54c17454baf2f9fe1bada282c
Autor:
Cynthia Hawkins, Daniel A. Morgenstern, Victoria J. Forster, Scott Lindhorst, Sumedha Sudhaman, Uri Tabori, An Van Damme, Eric Bouffet, Alexander Lossos, Ben George, Annika Bronsema, Anita Villani, Michael Osborn, Annie Huang, Yosef E. Maruvka, Melyssa Aronson, Patrick Tomboc, Michal Yalon-Oren, David S. Ziegler, Reid Hayes, Carol Durno, Vanessa Bianchi, Melissa Galati, Nuno Miguel Nunes, Magimairajan Issai Vanan, Vanja Cabric, Gregory Thomas, Nicholas Light, Scott Davidson, Matthew Zatzman, Michael D. Taylor, A. Sorana Morrissy, Martin Komosa, Melissa Edwards, Gary Mason, Jiil Chung, Adam Shlien, Gad Getz, Shriya Deshmukh, Alyssa Reddy, Karl P. Hodel, Zachary F. Pursell, Robert Siddaway, Maura Massimino, Enrico Opocher, Ledia Brunga, David Malkin, Ben Ho, Jacalyn Kelly, Daniel C. Bowers, Nathaniel D. Anderson, Valerie Larouche, Thomas A. Kunkel, Nicholas J. Haradhvala, Kristina A. Cole
Publikováno v:
Cancer Discov
Cancer discovery, Vol. 11, no. 5, p. 1176-1191 (2021)
Cancer discovery, Vol. 11, no. 5, p. 1176-1191 (2021)
Although replication repair deficiency, either by mismatch repair deficiency (MMRD) and/or loss of DNA polymerase proofreading, can cause hypermutation in cancer, microsatellite instability (MSI) is considered a hallmark of MMRD alone. By genome-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de55153537729f642eb68eecd06318c8
https://doi.org/10.1158/2159-8290.cd-20-0790
https://doi.org/10.1158/2159-8290.cd-20-0790
Autor:
Jonathan N. Byrd, James G. Jackson, Cynthia Hawkins, Alberto Martin, Uri Tabori, Walter J. Zahurancik, Dana Elshaer, Cynthia J. Guidos, Melissa Galati, Sumedha Sudhaman, Oz Mordechai, Ayse Bahar Ercan, Tomasz Sarosiek, Melyssa Aronson, Miki S. Gams, Victoria J. Forster, Taylor Bridge, Eric Bouffet, Andrea H. Seeley, Carol Durno, Melissa Edwards, Nathan Ungerleider, Vivian S. Park, Adam Shlien, Zachary F. Pursell, Lazar Joksimovic, Robert Siddaway, Nuno Miguel Nunes, Xia Wang, Zucai Suo, Iram Siddiqui, Jagadeesh Ramdas, Gavin P. Dunn, Jiil Chung, Richard de Borja, Karl P. Hodel
Publikováno v:
Cancer Research. 80:5606-5618
POLE mutations are a major cause of hypermutant cancers, yet questions remain regarding mechanisms of tumorigenesis, genotype–phenotype correlation, and therapeutic considerations. In this study, we establish mouse models harboring cancer-associate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72e350303ebf67f9812e527e5ce195b3
https://doi.org/10.1158/0008-5472.can-20-0624
https://doi.org/10.1158/0008-5472.can-20-0624
Autor:
Vivian S Park, Meijuan J S Sun, Wesley D Frey, Leonard G Williams, Karl P Hodel, Juliet D Strauss, Sydney J Wellens, James G Jackson, Zachary F Pursell
Publikováno v:
NAR Cancer. 4
Mutations in the exonuclease domain of POLE are associated with tumors harboring very high mutation burdens. The mechanisms linking this significant mutation accumulation and tumor development remain poorly understood. Pole+/P286R;Trp53+/– mice sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02c233d41a537deace5149c04b2221f7
https://doi.org/10.1093/narcan/zcac004
https://doi.org/10.1093/narcan/zcac004
Autor:
Zachary F. Pursell, Juliet D Strauss, Vivian S. Park, Wesley D. Frey, Sydney J Wellens, Leonard G. Williams, James G. Jackson, Meijuan Js Sun, Karl P. Hodel
Mutations in the exonuclease domain of POLE are associated with tumors harboring very high mutation burdens. The mechanisms linking this significant mutation accumulation and tumor development remain poorly understood. Pole+/P286R;Trp53+/− mice sho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf86055b02ae2f735dd72e12d7b66b95
https://doi.org/10.1101/2021.10.10.463847
https://doi.org/10.1101/2021.10.10.463847
Autor:
Meijuan J. Sun, Vivian S. Park, Wesley D. Frey, Leonard G. Williams, Karl P. Hodel, Juliet D. Strauss, Sydney J. Wellens, James G. Jackson, Zachary F. Pursell
Publikováno v:
Cancer Research. 82:1504-1504
Mutations in the exonuclease domain of POLE are associated with tumors harboring very high mutation burdens. The mechanisms linking this significant mutation accumulation and tumor development remain poorly understood. Pole+/P286R;Trp53+/- mice showe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95a6fd6db6a1d921a91e0fa2a0b33374
https://doi.org/10.1158/1538-7445.am2022-1504
https://doi.org/10.1158/1538-7445.am2022-1504