Zobrazeno 1 - 10
of 475
pro vyhledávání: '"Karl Ludwig, Laugwitz"'
Platelet mass cytometry reveals dysregulation of prothrombotic pathways in essential thrombocythemia
Autor:
Veronika Dill, Kilian Kirmes, Jiaying Han, Melissa Klug, Marc Rosenbaum, Giacomo Viggiani, Moritz von Scheidt, Markus List, Peter Herhaus, Jürgen Ruland, Florian Bassermann, Karl-Ludwig Laugwitz, Katharina S. Götze, Philipp J. Jost, Stefanie Jilg, Conor J. Bloxham, Philip W.J. Raake, Isabell Bernlochner, Dario Bongiovanni
Publikováno v:
Platelets, Vol 35, Iss 1 (2024)
Thromboembolic events are common in patients with essential thrombocythemia (ET). However, the pathophysiological mechanisms underlying the increased thrombotic risk remain to be determined. Here, we perform the first phenotypical characterization of
Externí odkaz:
https://doaj.org/article/6b03b9ff955e40ae9ff5ee319c518d34
Autor:
Gjin Ndrepepa, Salvatore Cassese, Robert A. Byrne, Blerina Bevapi, Michael Joner, Hendrik B. Sager, Sebastian Kufner, Erion Xhepa, Tareq Ibrahim, Karl‐Ludwig Laugwitz, Heribert Schunkert, Adnan Kastrati
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 21 (2024)
Background The association between left ventricular ejection fraction (LVEF) change (ΔLVEF) following percutaneous coronary intervention (PCI) and the long‐term mortality rate in patients with coronary artery disease is incompletely investigated.
Externí odkaz:
https://doaj.org/article/acc1735c326f4f7ebc085eb0ad265059
Autor:
Aleksandra M. Paciorek, Claudio E. von Schacky, Sarah C. Foreman, Felix G. Gassert, Florian T. Gassert, Jan S. Kirschke, Karl-Ludwig Laugwitz, Tobias Geith, Martin Hadamitzky, Jonathan Nadjiri
Publikováno v:
BMC Medical Imaging, Vol 24, Iss 1, Pp 1-13 (2024)
Abstract Background A deep learning (DL) model that automatically detects cardiac pathologies on cardiac MRI may help streamline the diagnostic workflow. To develop a DL model to detect cardiac pathologies on cardiac MRI T1-mapping and late gadoliniu
Externí odkaz:
https://doaj.org/article/a5ad92af55354f5f974c629581339eff
Autor:
Eimo Martens, Hans-Ulrich Haase, Giulio Mastella, Andreas Henkel, Christoph Spinner, Franziska Hahn, Congyu Zou, Augusto Fava Sanches, Julia Allescher, Daniel Heid, Elena Strauss, Melanie-Maria Maier, Mark Lachmann, Georg Schmidt, Dominik Westphal, Tobias Haufe, David Federle, Daniel Rueckert, Martin Boeker, Matthias Becker, Karl-Ludwig Laugwitz, Alexander Steger, Alexander Müller
Publikováno v:
Frontiers in Digital Health, Vol 6 (2024)
IntroductionToday, modern technology is used to diagnose and treat cardiovascular disease. These medical devices provide exact measures and raw data such as imaging data or biosignals. So far, the Broad Integration of These Health Data into Hospital
Externí odkaz:
https://doaj.org/article/176988035c0c45fcb7a158e6a7f97d46
Autor:
Tobias Koppara, Isabel Dregely, Stephan G. Nekolla, Jörg Nährig, Nicolas Langwieser, Christian Bradaric, Carl Ganter, Karl-Ludwig Laugwitz, Markus Schwaiger, Tareq Ibrahim
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundSimultaneous positron emission tomography (PET) and magnetic resonance imaging (MRI) is a novel hybrid imaging method integrating the advances of morphological tissue characterization of MRI with the pathophysiological insights of PET appli
Externí odkaz:
https://doaj.org/article/ec37c33fd7c44a4996b11225d72ec30d
Autor:
Dorota Zawada, Jessica Kornherr, Anna B. Meier, Gianluca Santamaria, Tatjana Dorn, Monika Nowak-Imialek, Daniel Ortmann, Fangfang Zhang, Mark Lachmann, Martina Dreßen, Mariaestela Ortiz, Victoria L. Mascetti, Stephen C. Harmer, Muriel Nobles, Andrew Tinker, Maria Teresa De Angelis, Roger A. Pedersen, Phillip Grote, Karl-Ludwig Laugwitz, Alessandra Moretti, Alexander Goedel
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The heart is formed from several spatiotemporally distinct progenitor pools during development. Here they show that modulation of retinoic acid signaling can instruct human pluripotent stems cells into heart progenitors that are useful for studying h
Externí odkaz:
https://doaj.org/article/10a747d5fcc140e6a38c4095415e2a1f
Autor:
Melissa Klug, Kilian Kirmes, Jiaying Han, Olga Lazareva, Marc Rosenbaum, Giacomo Viggiani, Moritz von Scheidt, Jürgen Ruland, Jan Baumbach, Gianluigi Condorelli, Karl-Ludwig Laugwitz, Markus List, Isabell Bernlochner, Dario Bongiovanni
Publikováno v:
Platelets, Vol 33, Iss 6, Pp 841-848 (2022)
Mass cytometry (CyTOF) is a new technology that allows the investigation of protein expression at single cell level with high resolution. While several protocols are available to investigate leukocyte expression, platelet staining and analysis with C
Externí odkaz:
https://doaj.org/article/7fc3a8132ec841acad8e1aeef211a611
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 5 (2023)
Externí odkaz:
https://doaj.org/article/157e044ef2334e2eade288edbfc84648
Autor:
Hilansi Rawat, Jessica Kornherr, Dorota Zawada, Sara Bakhshiyeva, Christian Kupatt, Karl-Ludwig Laugwitz, Andrea Bähr, Tatjana Dorn, Alessandra Moretti, Monika Nowak-Imialek
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Domestic pigs (Sus scrofa) share many genetic, anatomical, and physiological traits with humans and therefore constitute an excellent preclinical animal model. Fundamental understanding of the cellular and molecular processes governing early porcine
Externí odkaz:
https://doaj.org/article/92c757b9ac5643cbbc33c41437a503ed
Autor:
Alexander Steger, Michael Dommasch, Alexander Müller, Petra Barthel, Daniel Sinnecker, Larissa Wieg, Alexander Hapfelmeier, Helene Hildegard Heidegger, Katharina Maria Huster, Eimo Martens, Karl-Ludwig Laugwitz, Georg Schmidt, Ralf Dirschinger
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Survivors of an acute myocardial infarction with diabetes mellitus retain an increased mortality risk. Reliable assessment of individual risk is required for effective and cost-efficient medical care in these patients. The Polyscore is a pre
Externí odkaz:
https://doaj.org/article/0ea3cb22a7a240fb98999e081a99e40a