Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Karl Kramer"'
Autor:
Jana Zecha, Florian P. Bayer, Svenja Wiechmann, Julia Woortman, Nicola Berner, Julian Müller, Annika Schneider, Karl Kramer, Mar Abril-Gil, Thomas Hopf, Leonie Reichart, Lin Chen, Fynn M. Hansen, Severin Lechner, Patroklos Samaras, Stephan Eckert, Ludwig Lautenbacher, Maria Reinecke, Firas Hamood, Polina Prokofeva, Larsen Vornholz, Chiara Falcomatà, Madeleine Dorsch, Ayla Schröder, Anton Venhuizen, Stephanie Wilhelm, Guillaume Médard, Gabriele Stoehr, Jürgen Ruland, Barbara M. Grüner, Dieter Saur, Maike Buchner, Benjamin Ruprecht, Hannes Hahne, Matthew The, Mathias Wilhelm, Bernhard Kuster
Although most cancer drugs modulate the activities of cellular pathways by changing posttranslational modifications (PTMs), little is known regarding the extent and the time- and dose-response characteristics of drug-regulated PTMs. In this work, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c87d1d00a70e16be3fa10729e9a3ae2
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85152012772
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85152012772
Autor:
Severin Lechner, Martin Ian P. Malgapo, Christian Grätz, Raphael R. Steimbach, Agnes Baron, Patrick Rüther, Simon Nadal, Carmen Stumpf, Christina Loos, Xin Ku, Polina Prokofeva, Ludwig Lautenbacher, Tino Heimburg, Vivian Würf, Chen Meng, Mathias Wilhelm, Wolfgang Sippl, Karin Kleigrewe, Josch K. Pauling, Karl Kramer, Aubry K. Miller, Michael W. Pfaffl, Maurine E. Linder, Bernhard Kuster, Guillaume Médard
Publikováno v:
Nature Chemical Biology. 18:913-913
Autor:
Gabriel Lassabe, Bruce D. Hammock, Gualberto González-Sapienza, Karl Kramer, Andrés González-Techera
Publikováno v:
Analytical chemistry, vol 90, iss 10
Our group has previously developed immunoassays for noncompetitive detection of small molecules based on the use of phage borne anti-immunocomplex peptides. Recently, we substituted the phage particles by biotinylated synthetic anti-immunocomplex pep
Autor:
Andreas Huhmer, Tobias Schmidt, Derek J. Bailey, Stephan Aiche, Johannes Zerweck, Daniel P Zolg, Eric W. Deutsch, Bernhard Kuster, Robert L. Moritz, Ruedi Aebersold, Thomas Moehring, Peng Yu, Bernard Delanghe, Tobias Knaute, Judith Schlegl, Siegfried Gessulat, Karsten Schnatbaum, Ulf Reimer, Maximilian Weininger, Hans-Christian Ehrlich, Ulrike Kusebauch, Mathias Wilhelm, Karl Kramer, Holger Wenschuh
Publikováno v:
Nature Methods
Nature Methods, 14 (3)
Nature Methods, 14 (3)
We describe ProteomeTools, a project building molecular and digital tools from the human proteome to facilitate biomedical research. Here we report the generation and multimodal liquid chromatography-tandem mass spectrometry analysis of >330,000 synt
Autor:
Chen Meng, Heiner Koch, Riccardo Zenezini Chiozzi, Stefan Knapp, Karl Kramer, Susan Klaeger, Enric Domingo, Stephanie Heinzlmeir, Julia Slotta-Huspenina, Wilko Weichert, Bernhard Kuster, Stephan M. Feller, Anna Jarzab, Runsheng Zheng, Mathias Wilhelm, Elaine C. Johnstone, David J. Kerr, Benjamin Ruprecht, Moritz Jesinghaus, Martin Frejno
Publikováno v:
Molecular Systems Biology
Colorectal cancer (CRC) is one of the top three most common cancers and among the top four causes of cancer-related deaths worldwide (Torre et al., 2015). CRC patients are well characterised on the transcriptome and proteome level, but proteomics dat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d19c5cba5afe83c3c8b032aaa32b07a
https://ora.ox.ac.uk/objects/uuid:6db32cfe-48c4-47f0-9f94-925d784ab335
https://ora.ox.ac.uk/objects/uuid:6db32cfe-48c4-47f0-9f94-925d784ab335
Autor:
Natasha Danda, Guillaume Médard, Chris Williams, Alexandra Schindl, Jonas Lohse, Bernhard Kuster, Karl Kramer, Martin D. Witte
Publikováno v:
Chem. Commun., 53(87), 11929-11932. ROYAL SOC CHEMISTRY
A method for identifying probe modification of proteins via tandem mass spectrometry was developed. Azide bearing molecules are immobilized on functionalised sepharose beads via copper catalysed Huisgen-type click chemistry and selectively released u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5378bae7aa44173c62a350a2645b8d4d
https://research.rug.nl/en/publications/c353f980-d0c8-49ba-8bd9-a56ee5ffda9d
https://research.rug.nl/en/publications/c353f980-d0c8-49ba-8bd9-a56ee5ffda9d
Autor:
Stefania Re Depaolini, Tõnu Vooder, Paul-Albert Koenig, Jana Zecha, Mathias Wilhelm, Florian Bassermann, Harald Polzer, Tobias Schmidt, Hannes Hahne, Jan Huenges, Judith Schlegl, Axel Walch, Irmela Jeremias, Stephanie Heinzlmeir, Binje Vick, Bernhard Kuster, Bjoern-Oliver Gohlke, Dominic Helm, Karsten Spiekermann, Karl Kramer, Daniel P Zolg, Neeme Tõnisson, Juergen Ruland, Hans-Christian Ehrlich, Annette Feuchtinger, Wilhelm Becker, Benjamin Ruprecht, Katharina Götze, Svenja Petzoldt, Stephan Aiche, Lars Rueckert, Susan Klaeger, Sabine Schneider, Melanie Schoof, Anne-Kathrin Garz, Maria Reinecke, G. Canevari, Eduard R. Felder, Guillaume Médard, Chen Meng, Philipp A. Greif, Gian Kayser, Elena Casale, Zhixiang Wu, Robert Preissner, Heiner Koch, Huichao Qiao, Katrin Reiter
Publikováno v:
Science
Science 358:eaan4368 (2017)
Science 358:eaan4368 (2017)
An atlas for drug interactions Kinase inhibitors are an important class of drugs that block certain enzymes involved in diseases such as cancer and inflammatory disorders. There are hundreds of kinases within the human body, so knowing the kinase “
Autor:
Andrej Bluwstein, Zhixiang Wu, Konrad Müller, Simone Lemeer, Bernhard Kuster, Karl Kramer, Julia Leberfinger
Publikováno v:
Journal of Proteomics. 75:3465-3477
The receptor tyrosine kinase DDR1 has been implicated in multiple human cancers and fibrosis and is targeted by the leukemia drug Gleevec. This suggests that DDR1 might be a new therapeutic target. However, further insight into the DDR1 signaling pat
Publikováno v:
Analytical Letters. 43:119-132
The development of a monoclonal antibody enables a specific and sensitive detection of a potentially allergenic epitope from proglycinin in soy and constitutes an appropriate tool for analytical purposes in medical diagnostics and food labeling. Prog
Autor:
Susan Klaeger, Benjamin Ruprecht, Zhixiang Wu, Fiona Pachl, Carsten Hopf, Karl Kramer, Xin Ku, Stephanie Heinzlmeir, Dominic Helm, Guillaume Médard, Antje Dittmann, Bernhard Kuster, Mathias Wilhelm, Huichao Qiao, Thomas Kuehne
Publikováno v:
Journal of proteome research. 14(3)
Solid supported probes have proven to be an efficient tool for chemical proteomics. The kinobeads technology features kinase inhibitors covalently attached to Sepharose for affinity enrichment of kinomes from cell or tissue lysates. This technology,