Výsledky vyhledávání - "Karl Kornacker"

Akademický článek

Age-associated disruption of molecular clock expression in skeletal muscle of the spontaneously hypertensive rat.

Autor: Mitsunori Miyazaki, Elizabeth Schroder, Stephanie E Edelmann, Michael E Hughes, Karl Kornacker, C William Balke, Karyn A Esser

Publikováno v: PLoS ONE, Vol 6, Iss 11, p e27168 (2011)

It is well known that spontaneously hypertensive rats (SHR) develop muscle pathologies with hypertension and heart failure, though the mechanism remains poorly understood. Woon et al. (2007) linked the circadian clock gene Bmal1 to hypertension and m

Externí odkaz: https://doaj.org/article/369e7471af7f48568e8746552ebabde8

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Akademický článek

Accurate expression profiling of very small cell populations.

Autor: Eva Gonzalez-Roca, Xabier Garcia-Albéniz, Silvia Rodriguez-Mulero, Roger R Gomis, Karl Kornacker, Herbert Auer

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14418 (2010)

BACKGROUND: Expression profiling, the measurement of all transcripts of a cell or tissue type, is currently the most comprehensive method to describe their physiological states. Given that accurate profiling methods currently available require RNA am

Externí odkaz: https://doaj.org/article/7bab709ebba9412e9de75c6f3f45173b

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Cyclobutane Pyrimidine Dimer Hyperhotspots as Sensitive Indicators of Keratinocyte UV Exposure

Autor: Alejandro Garcia‐Ruiz, Karl Kornacker, Douglas E. Brash

Publikováno v: Photochemistry and photobiology. 98(5)

The dominant DNA damage generated by UV exposure is the cyclobutane pyrimidine dimer (CPD), which alters skin cell physiology and induces cell death and mutation. Genome-wide nucleotide-resolution analysis of CPDs in melanocytes and fibroblasts has i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c9d028d8c60a927d3771d7b5cb71f49
https://pubmed.ncbi.nlm.nih.gov/35944237

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Genomic sites hypersensitive to ultraviolet radiation

Autor: Karl Kornacker, James R. Knight, Sanjay Premi, Dejian Zhao, Lynn Han, Douglas E. Brash, Meg A Palmatier, Sameet Mehta

Publikováno v: Proc Natl Acad Sci U S A

If the genome contains outlier sequences extraordinarily sensitive to environmental agents, these would be sentinels for monitoring personal carcinogen exposure and might drive direct changes in cell physiology rather than acting through rare mutatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7273d31522e3807d8f4861875c5f5aa4
https://doi.org/10.1073/pnas.1907860116

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Guidelines for Genome-Scale Analysis of Biological Rhythms

Autor: Achim Kramer, Karl Kornacker, Justin Blau, Susan S. Golden, Samuel S. C. Rund, Michael H. Hastings, Han Wang, Joanna C. Chiu, Pierre Baldi, Andrew J. Millar, David Gatfield, Tanya L. Leise, Christy Hoffmann, María Teresa Camacho Olmedo, Scott Sherrill-Mix, Derk-Jan Dijk, Debra J. Skene, Jason P. DeBruyne, Hanspeter Herzel, Charles J. Weitz, Gad Asher, Jiajia Li, Katja A. Lamia, Francis J. Doyle, John B. Hogenesch, Tomasz Zielinski, Stacey L. Harmer, Xiaodong Li, Jacob J. Hughey, Christian I. Hong, Zheng Chen, Michael Rosbash, Jennifer J. Loros, Maria S. Robles, Jennifer M. Hurley, Jerome S. Menet, Scott A. Lewis, Karyn A. Esser, Juergen Cox, M. Fernanda Ceriani, Ying-Hui Fu, Joseph S. Takahashi, Ying Xu, Hiroki R. Ueda, Giles E. Duffield, Garret A. FitzGerald, Michael E. Hughes, Deborah Bell-Pedersen, Carl Hirschie Johnson, Marc D. Ruben, Felix Naef, Paul de Goede, Amita Sehgal, Horacio O. de la Iglesia, Akhilesh B. Reddy, Alaaddin Bulak Arpat, Todd C. Mockler, Emi Nagoshi, Dmitri A. Nusinow, Luciano DiTacchio, Gang Wu, Lauren J. Francey, John Harer, Steve A. Kay, Charissa de Bekker, Aziz Sancar, Ron C. Anafi, Katherine C. Abruzzi, Seung Hee Yoo, Kai-Florian Storch, Nobuya Koike, Daniel B. Forger, Erik D. Herzog, Andrew C. Liu, Louis J. Ptáček, Carla B. Green, Michael W. Young, Michael N. Nitabach, Eric E. Zhang, Jay C. Dunlap, Alexander M. Crowell, Tami A. Martino, Frédéric Gachon, Ravi Allada, Pål O. Westermark, Till Roenneberg, Martha Merrow, Herman Wijnen, Kristin Eckel-Mahan, Steve Brown, Jeff Haspel, Paolo Sassone-Corsi, David A. Rand

Publikováno v: Journal of Biological Rhythms, vol. 32, no. 5, pp. 380-393
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Journal of biological rhythms, 32(5), 380-393. SAGE Publications Inc.
Journal of Biological Rhythms
Hughes, M E, Abruzzi, K C, Allada, R, Anafi, R, Arpat, A B, Asher, G, Baldi, P, de Bekker, C, Bell-Pedersen, D, Blau, J, Brown, S, Ceriani, M F, Chen, Z, Chiu, J C, Cox, J, Crowell, A M, DeBruyne, J P, Dijk, D-J, DiTacchio, L, Doyle, F J, Duffield, G E, Dunlap, J C, Eckel-Mahan, K, Esser, K A, FitzGerald, G A, Forger, D B, Francey, L J, Fu, Y-H, Gachon, F, Gatfield, D, de Goede, P, Golden, S S, Green, C, Harer, J, Harmer, S, Haspel, J, Hastings, M H, Herzel, H, Herzog, E D, Hoffmann, C, Hong, C, Hughey, J J, Hurley, J M, de la Iglesia, H O, Johnson, C, Kay, S A, Koike, N, Kornacker, K, Kramer, A, Lamia, K, Leise, T, Lewis, S A, Li, J, Li, X, Liu, A C, Loros, J J, Martino, T A, Menet, J S, Merrow, M, Millar, A J, Mockler, T, Naef, F, Nagoshi, E, Nitabach, M N, Olmedo, M, Nusinow, D A, Ptáček, L J, Rand, D, Reddy, A B, Robles, M S, Roenneberg, T, Rosbash, M, Ruben, M D, Rund, S S C, Sancar, A, Sassone-Corsi, P, Sehgal, A, Sherrill-Mix, S, Skene, D J, Storch, K-F, Takahashi, J S, Ueda, H R, Wang, H, Weitz, C, Westermark, P O, Wijnen, H, Xu, Y, Wu, G, Yoo, S-H, Young, M, Zhang, E E, Zielinski, T & Hogenesch, J B 2017, ' Guidelines for Genome-Scale Analysis of Biological Rhythms ', Journal of biological rhythms, vol. 32, no. 5, 748730417728663, pp. 380-393 . https://doi.org/10.1177/0748730417728663
Hughes, ME; Abruzzi, KC; Allada, R; Anafi, R; Arpat, AB; Asher, G; et al.(2017). Guidelines for Genome-Scale Analysis of Biological Rhythms. Journal of Biological Rhythms, 32(5), 380-393. doi: 10.1177/0748730417728663. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/2dq117tj
Journal of biological rhythms, 32(5): 380-393

Genome biology approaches have made enormous contributions to our understanding of biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and metabolites, whose abundance oscillates throughout the day. These m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98132f5b6879e2975b22c568261f17f7
https://doi.org/10.1177/0748730417728663

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Abstract PR01: Genomic UV-hypersensitive sites as sentinels for personal UV exposure

Autor: Sanjay Premi, Lynn Han, Sameet Mehta, James Knight, Dejian Zhao, Antonella Bacchiocchi, Ruth Halaban, Meg A. Palmatier, Karl Kornacker, Douglas E. Brash

Publikováno v: Cancer Prevention Research. 13:PR01-PR01

The largest risk factor for skin cancers such as melanoma is past sun exposure, so an objective measurement of traces of an individual’s sun history would allow a general practitioner to identify people who should be monitored for early cancer dete

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9627667cb7f9685b8bdd5473202263c8
https://doi.org/10.1158/1940-6215.envcaprev19-pr01

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MetaCycle: an integrated R package to evaluate periodicity in large scale data

Autor: Ron C. Anafi, Karl Kornacker, Michael E. Hughes, Gang Wu, John B. Hogenesch

Summary: Detecting periodicity in large scale data remains a challenge. While efforts have been made to identify best of breed algorithms, relatively little research has gone into integrating these methods in a generalizable method. Here, we present

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc1aa1bf6e675f801c0e04d1f77d4ae5
https://doi.org/10.1101/040345

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Transcriptional profiling of the megabladder mouse: A unique model of bladder dysmorphogenesis

Autor: Monalee Saha, Karl Kornacker, Herbert Auer, Michael L. Robinson, Carlton M. Bates, Sunita Singh, Ihab Ismail, Melissa Robinson, Kirk M. McHugh

Publikováno v: Developmental Dynamics. 237:170-186

Recent studies in our lab identified a mutant mouse model of obstructive nephropathy designated mgb for megabladder. Homozygotic mgb mice (mgb−/−) develop lower urinary tract obstruction in utero due to a lack of bladder smooth muscle differentia

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db29a08d273497574e0b9e6d88f8dfed
https://doi.org/10.1002/dvdy.21391

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The Triform algorithm: improved sensitivity and specificity in ChIP-Seq peak finding

Autor: Tony Håndstad, Morten Beck Rye, Finn Drabløs, Karl Kornacker

Publikováno v: BMC Bioinformatics
BMC Bioinformatics, Vol 13, Iss 1, p 176 (2012)

Background Chromatin immunoprecipitation combined with high-throughput sequencing (ChIP-Seq) is the most frequently used method to identify the binding sites of transcription factors. Active binding sites can be seen as peaks in enrichment profiles w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1100bb7e9a1aef123e8b1369c0766739
https://doi.org/10.1186/1471-2105-13-176

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