Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Karl Josef, Föhr"'
Autor:
Eva Fuchs, David Alexander Christian Messerer, Georg Karpel-Massler, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Karl Josef Föhr
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Background: Tumor therapeutics are aimed to affect tumor cells selectively while sparing healthy ones. For this purpose, a huge variety of different drugs are in use. Recently, also blockers of voltage-gated sodium channels (VGSCs) have been recogniz
Externí odkaz:
https://doaj.org/article/ea8b12b4d6c54831986fd1d8e41a7744
Autor:
Lisa Wohlgemuth, Alexander Elias Paul Stratmann, Frederik Münnich, Stefan Bernhard, Bertram Dietrich Thomaß, Finn Münnich, Adam Omar Khalaf Mohamed, Marco Mannes, Christoph Quirin Schmidt, Kristina Nilsson Ekdahl, Bo Nilsson, Michael Fauler, Karl Josef Föhr, Markus Huber-Lang, David Alexander Christian Messerer
Publikováno v:
Cells, Vol 11, Iss 20, p 3297 (2022)
The cellular and fluid phase-innate immune responses of many diseases predominantly involve activated neutrophil granulocytes and complement factors. However, a comparative systematic analysis of the early impact of key soluble complement cleavage pr
Externí odkaz:
https://doaj.org/article/db36629063ec4c59a107324e29498e2a
Autor:
Stefan Hug, Stefan Bernhard, Alexander Elias Paul Stratmann, Maike Erber, Lisa Wohlgemuth, Christiane Leonie Knapp, Jonas Martin Bauer, Laura Vidoni, Michael Fauler, Karl Josef Föhr, Peter Radermacher, Andrea Hoffmann, Markus Huber-Lang, David Alexander Christian Messerer
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Platelet-activating factor (PAF) is an important mediator of the systemic inflammatory response. In the case of sepsis, proper activation and function of neutrophils as the first line of cellular defense are based on a well-balanced physiological res
Externí odkaz:
https://doaj.org/article/5547ca7041df478095f408b281305e1d
Autor:
Karl Josef Föhr, Ariadni Nastos, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, David Alexander Christian Messerer
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Atomoxetine, a neuroactive drug, is approved for the treatment of attention-deficit/hyperactivity disorder (ADHD). It is primarily known as a high affinity blocker of the noradrenaline transporter, whereby its application leads to an increased level
Externí odkaz:
https://doaj.org/article/317ba4affcba473d8d930d70d3d8f639
Autor:
Alexander Elias Paul Stratmann, Lisa Wohlgemuth, Maike Elisabeth Erber, Stefan Bernhard, Stefan Hug, Michael Fauler, Laura Vidoni, Adam Omar Khalaf Mohamed, Bertram Dietrich Thomaß, Frederik Münnich, Laura Stukan, Karl Josef Föhr, Marco Mannes, Markus Stefan Huber-Lang, David Alexander Christian Messerer
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1504 (2021)
Neutrophils provide rapid and efficient defense mechanisms against invading pathogens. Upon stimulation with proinflammatory mediators, including complement factors and bacterial peptides, neutrophils respond with changes in their membrane potential,
Externí odkaz:
https://doaj.org/article/d686275d19eb4ea392ad8bb551c7eabe
Autor:
Karl Josef Föhr, Michael Rapp, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, David Alexander Christian Messerer
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 21; Pages: 12890
Aripiprazole is an atypical antipsychotic drug, which is prescribed for many psychiatric diseases such as schizophrenia and mania in bipolar disorder. It primarily acts as an agonist of dopaminergic and other G-protein coupled receptors. So far, an i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37e7f8b666f728f220ed7921138f5ae7
https://pubmed.ncbi.nlm.nih.gov/36361681
https://pubmed.ncbi.nlm.nih.gov/36361681
Autor:
Melanie, Mettang, Viola, Meyer-Pannwitt, Georg, Karpel-Massler, Shaoxia, Zhou, Neil O, Carragher, Karl Josef, Föhr, Bernd, Baumann, Lisa, Nonnenmacher, Stefanie, Enzenmüller, Meike, Dahlhaus, Markus D, Siegelin, Sebastien, Stroh, Daniel, Mertens, Pamela, Fischer-Posovszky, E Marion, Schneider, Marc-Eric, Halatsch, Klaus-Michael, Debatin, Mike-Andrew, Westhoff
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018)
Scientific Reports
Scientific Reports
Due to the highly invasive nature of Glioblastoma (GB), complete surgical resection is not feasible, while motile tumour cells are often associated with several specific brain structures that enhance treatment-resistance. Here, we investigate the the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5850f091883cddaeb023143ff44e6847
http://link.springer.com/article/10.1038/s41598-018-23592-z
http://link.springer.com/article/10.1038/s41598-018-23592-z
Autor:
Raphael, Hesse, Bjoern, von Einem, Franziska, Wagner, Patricia, Bott, Daniel, Schwanzar, Rosemary J, Jackson, Karl Josef, Föhr, Ludwig, Lausser, Katja S, Kroker, Christian, Proepper, Paul, Walther, Hans A, Kestler, Tara L, Spires-Jones, Tobias, Boeckers, Holger, Rosenbrock, Christine A F, von Arnim
Publikováno v:
Experimental neurology. 304
One major pathophysiological hallmark of Alzheimer's disease (AD) is senile plaques composed of amyloid β (Aβ). In the amyloidogenic pathway, cleavage of the amyloid precursor protein (APP) is shifted towards Aβ production and soluble APPβ (sAPP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::343cb254e1375635f29c4839f4f337ca
https://pubmed.ncbi.nlm.nih.gov/29466703
https://pubmed.ncbi.nlm.nih.gov/29466703
Autor:
Jean-François Ghersi-Egea, Karl-Josef Föhr, Burkhard Schlosshauer, Stefan Fennrich, David E. Ray, Heike Stier
Publikováno v:
Methods in Cell Science. 18:283-291
The goal of the current research was to define an in vitro system that can replace in vivo experimentation but reflects as far as possible aspects of the intact situation of the developing nervous system of mammals. Tissue slices of postnatal rat hip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3353a5e65b146149b23eaf6d51f19cd4
https://doi.org/10.1007/bf00127905
https://doi.org/10.1007/bf00127905
Autor:
Oliver, Adolph, Karl Josef, Föhr
Publikováno v:
Current clinical pharmacology.
Recent investigations of pain mechanisms leading to the induction and maintenance of long-term potentiation (LTP) in the spinal cord have identified a huge number of molecular targets that might be appropriate for therapeutically intervention. In thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dcdabc744f711589b3d20594c0cad75d
https://pubmed.ncbi.nlm.nih.gov/22283614
https://pubmed.ncbi.nlm.nih.gov/22283614