Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Karl J. Wahlin"'
Autor:
Jason W. Adams, Annabelle Vinokur, Janaína S. de Souza, Charles Austria, Bruno S. Guerra, Roberto H. Herai, Karl J. Wahlin, Alysson R. Muotri
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113867- (2024)
Summary: Individuals with Williams syndrome (WS), a neurodevelopmental disorder caused by hemizygous loss of 26–28 genes at 7q11.23, characteristically portray a hypersocial phenotype. Copy-number variations and mutations in one of these genes, GTF
Externí odkaz:
https://doaj.org/article/77e344c08eb6407895cdd8d2439e33a3
Autor:
Devansh Agarwal, Nicholas Dash, Kevin W. Mazo, Manan Chopra, Maria P. Avila, Amit Patel, Ryan M. Wong, Cairang Jia, Hope Do, Jie Cheng, Colette Chiang, Shawna L. Jurlina, Mona Roshan, Michael W. Perry, Jong M. Rho, Risa Broyer, Cassidy D. Lee, Robert N. Weinreb, Cezar Gavrilovici, Nicholas W. Oesch, Derek S. Welsbie, Karl J. Wahlin
Publikováno v:
npj Regenerative Medicine, Vol 8, Iss 1, Pp 1-18 (2023)
Abstract In optic neuropathies, including glaucoma, retinal ganglion cells (RGCs) die. Cell transplantation and endogenous regeneration offer strategies for retinal repair, however, developmental programs required for this to succeed are incompletely
Externí odkaz:
https://doaj.org/article/382428f7635b42d8a434f9b8270d4a90
Autor:
Devansh Agarwal, Rian Kuhns, Christos N. Dimitriou, Emmalyn Barlow, Karl J. Wahlin, Ray A. Enke
Publikováno v:
Scientific Data, Vol 9, Iss 1, Pp 1-8 (2022)
Measurement(s) mRNA Sequencing Technology Type(s) Next Generation Sequencing Factor Type(s) Tissue Source • Tissue Type Sample Characteristic - Organism Homo sapiens Sample Characteristic - Environment cell culture
Externí odkaz:
https://doaj.org/article/e88a6e7fbb0444ab97101dd30188d4ed
Autor:
Itzy E. Morales Pantoja, Lena Smirnova, Alysson R. Muotri, Karl J. Wahlin, Jeffrey Kahn, J. Lomax Boyd, David H. Gracias, Timothy D. Harris, Tzahi Cohen-Karni, Brian S. Caffo, Alexander S. Szalay, Fang Han, Donald J. Zack, Ralph Etienne-Cummings, Akwasi Akwaboah, July Carolina Romero, Dowlette-Mary Alam El Din, Jesse D. Plotkin, Barton L. Paulhamus, Erik C. Johnson, Frederic Gilbert, J. Lowry Curley, Ben Cappiello, Jens C. Schwamborn, Eric J. Hill, Paul Roach, Daniel Tornero, Caroline Krall, Rheinallt Parri, Fenna Sillé, Andre Levchenko, Rabih E. Jabbour, Brett J. Kagan, Cynthia A. Berlinicke, Qi Huang, Alexandra Maertens, Kathrin Herrmann, Katya Tsaioun, Raha Dastgheyb, Christa Whelan Habela, Joshua T. Vogelstein, Thomas Hartung
Publikováno v:
Frontiers in Artificial Intelligence, Vol 6 (2023)
The brain is arguably the most powerful computation system known. It is extremely efficient in processing large amounts of information and can discern signals from noise, adapt, and filter faulty information all while running on only 20 watts of powe
Externí odkaz:
https://doaj.org/article/aebc0f0cd878418ebed9205a612b1932
Publikováno v:
Stem Cell Research, Vol 66, Iss , Pp 103006- (2023)
Müller glia are non-neuronal support cells that play a vital role in the homeostasis of the eye. Their radial-oriented processes span the width of the retina and respond to injury through a cellular response that can be detrimental or protective dep
Externí odkaz:
https://doaj.org/article/c38895d84b1943e6b8121c866cd31cef
Autor:
Srinivasa R. Sripathi, Ming-Wen Hu, Ravi Chakra Turaga, Rebekah Mikeasky, Ganesh Satyanarayana, Jie Cheng, Yukan Duan, Julien Maruotti, Karl J. Wahlin, Cynthia A. Berlinicke, Jiang Qian, Noriko Esumi, Donald J. Zack
Publikováno v:
Cells, Vol 12, Iss 8, p 1155 (2023)
Epithelial-mesenchymal transition (EMT), which is well known for its role in embryonic development, malignant transformation, and tumor progression, has also been implicated in a variety of retinal diseases, including proliferative vitreoretinopathy
Externí odkaz:
https://doaj.org/article/d5409e6c65bb44babe7141eeb0848c9b
Autor:
Shawna L. Jurlina, Melissa K. Jones, Devansh Agarwal, Diana V. De La Toba, Netra Kambli, Fei Su, Heather M. Martin, Ryan Anderson, Ryan M. Wong, Justin Seid, Saisantosh V. Attaluri, Melissa Chow, Karl J. Wahlin
Publikováno v:
Genes, Vol 13, Iss 12, p 2363 (2022)
Pluripotent stem cells (PSCs) offer an exciting resource for probing human biology; however, gene-editing efficiency remains relatively low in many cell types, including stem cells. Gene-editing using the CRISPR-Cas9 system offers an attractive solut
Externí odkaz:
https://doaj.org/article/c3d363319b4447f2a0aa2d600cc60a08
Autor:
Elizabeth Gage, Devansh Agarwal, Calvin Chenault, Kameron Washington-Brown, Sarah Szvetecz, Nusrat Jahan, Zixiao Wang, Melissa K. Jones, Donald J. Zack, Ray A. Enke, Karl J. Wahlin
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 14 (2022)
Complex transcriptional gene regulation allows for multifaceted isoform production during retinogenesis, and novel isoforms transcribed from a single locus can have unlimited potential to code for diverse proteins with different functions. In this st
Externí odkaz:
https://doaj.org/article/e291028d982b4cdc981fb3079bc96c40
Autor:
Kang-Chieh Huang, Mong-Lien Wang, Shih-Jen Chen, Jean-Cheng Kuo, Won-Jing Wang, Phan Nguyen Nhi Nguyen, Karl J. Wahlin, Jyh-Feng Lu, Audrey A. Tran, Michael Shi, Yueh Chien, Aliaksandr A. Yarmishyn, Ping-Hsing Tsai, Tien-Chun Yang, Wann-Neng Jane, Chia-Ching Chang, Chi-Hsien Peng, Thorsten M. Schlaeger, Shih-Hwa Chiou
Publikováno v:
Stem Cell Reports, Vol 13, Iss 5, Pp 906-923 (2019)
Summary: X-linked juvenile retinoschisis (XLRS), linked to mutations in the RS1 gene, is a degenerative retinopathy with a retinal splitting phenotype. We generated human induced pluripotent stem cells (hiPSCs) from patients to study XLRS in a 3D ret
Externí odkaz:
https://doaj.org/article/b9f017c6d6624217abb79abd14c148e3
Autor:
Karl J. Wahlin, Jie Cheng, Shawna L. Jurlina, Melissa K. Jones, Nicholas R. Dash, Anna Ogata, Nawal Kibria, Sunayan Ray, Kiara C. Eldred, Catherine Kim, Jacob S. Heng, Jenny Phillips, Robert J. Johnston, David M. Gamm, Cynthia Berlinicke, Donald J. Zack
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Human pluripotent stem cells (PSCs) represent a powerful tool to investigate human eye development and disease. When grown in 3D, they can self-assemble into laminar organized retinas; however, variation in the size, shape and composition of individu
Externí odkaz:
https://doaj.org/article/9163c7a815ae44529b224062f12f13fe