Abrogation of esophageal carcinoma development in miR-31 knockout rats

Autor: Karl J. Smalley, Ruiyan Jing, Sili Fan, Carlo M. Croce, Guidantonio Malagoli Tagliazucchi, Louise Y.Y. Fong, Oliver Fiehn, Joseph Altemus, Cristian Taccioli, Kay Huebner, Alexey Palamarchuk, John L. Farber

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 117, iss 11
Proceedings of the National Academy of Sciences of the United States of America

Significance ESCC is a deadly disease with few prevention or treatment options. In a dietary Zn deficiency-promoted rat ESCC model with miR-31–controlled inflammation pathway up-regulation, systemic antimiR-31 reduces miR-31 level and inflammation,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0b9f7bf86c61ecc8eb7556a592d2aa8
http://hdl.handle.net/11577/3339098

Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats

Autor: Kay Huebner, Oliver Fiehn, Zi-Xuan Wang, Sili Fan, Karl J. Smalley, Hongping Chen, Carlo M. Croce, Ruiyan Jing, John L. Farber, Louise Y.Y. Fong, Hansjuerg Alder, Cristian Taccioli

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 115, iss 47
Proceedings of the National Academy of Sciences of the United States of America

Significance Prostate cancer in man is associated with Zn loss, citrate metabolite reduction, overexpression of the miR-183-96-182 cluster, and regulation of Zn homeostasis through Zn transporter suppression. Our mechanistic study shows that a low-Zn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e402208eedbe9795b5c1fdc53aff4e0
https://escholarship.org/uc/item/5gz4s3fb

Dysregulation of miR-31 and miR-21 induced by zinc deficiency promotes esophageal cancer

Autor: Yubao Jiang, Karl J. Smalley, Louise Y.Y. Fong, Kay Huebner, Paolo Fadda, Hansjuerg Alder, Hatice Gulcin Ozer, Hongping Chen, Carlo M. Croce, John L. Farber, Cristian Taccioli

Publikováno v: Carcinogenesis. 33:1736-1744

Zinc deficiency (ZD) increases the risk of esophageal squamous cell carcinoma (ESCC). In a rat model, chronic ZD induces an inflammatory gene signature that fuels ESCC development. microRNAs regulate gene expression and are aberrantly expressed in ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48725c99499242156182308403abf7dd
https://doi.org/10.1093/carcin/bgs204

Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: Inefficacy of genetic or pharmacological disruption of COX-2

Autor: Xianglan Liu, Louise Y.Y. Fong, Yubao Jiang, Karl J. Smalley, Denis C. Guttridge, Maurisa Riley, John L. Farber

Publikováno v: International Journal of Cancer. 122:978-989

Zinc deficiency in humans is associated with an increased risk of upper aerodigestive tract (UADT) cancer. In rodents, zinc deficiency predisposes to carcinogenesis by causing proliferation and alterations in gene expression. We examined whether in z

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9981d4a2e25c23a35e03c09c53cf625
https://doi.org/10.1002/ijc.23221

Protein, fat, and carbohydrate requirements during starvation: anaplerosis and cataplerosis

Autor: Oliver E Owen, Karl J Smalley, David A D’Alessio, Maria A Mozzoli, Elizabeth K Dawson

Publikováno v: The American Journal of Clinical Nutrition. 68:12-34

The purpose of this work was to clarify the essentiality of glucose production from amino acids in obese subjects undergoing prolonged starvation and to provide an explanation for death after the depletion of lean body mass when some body fat is stil

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49acd1ed0d7522a8e85234186abf4acb
https://doi.org/10.1093/ajcn/68.1.12