Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Karl J. Mathis"'
Autor:
Huey-Sheng Shieh, Grace E. Munie, Nicole Caspers, Alfredo G. Tomasselli, James R. Kiefer, Karl J. Mathis, Arthur J. Wittwer, Micky D. Tortorella, Scott S. Woodard, Mark E. Schnute, Jennifer M. Williams, Anne-Marie Malfait
Publikováno v:
Protein Science. 20:735-744
A ((1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl) succinamide derivative (here referred to as Compound 12) shows significant activity toward many matrix metalloproteinases (MMPs), including MMP-2, MMP-8, MMP-9, and MMP-13. Modeling studies had predicte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7956cccbf2929ee94ea4a421918afe33
https://doi.org/10.1002/pro.606
https://doi.org/10.1002/pro.606
Autor:
Beverly A. Reitz, Joseph W. Leone, Michael J. Bienkowski, Daniel F. Curran, Karl J. Mathis, Thomas L. Emmons, Jacqueline E. Day, Mary E. Shuck, Mark C. Walker, Alfredo G. Tomasselli, H. David Fischer
Publikováno v:
Protein Expression and Purification. 65:133-139
Soluble guanylate cyclase (sGC) has been purified from 100 L cell culture infected by baculovirus using the newer and highly effective titerless infected-cells preservation and scale-up (TIPS) method. Successive passage of the enzyme through DEAE, Ni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429666b5c5f068867bf311b4dcaba1ae
https://doi.org/10.1016/j.pep.2009.01.001
https://doi.org/10.1016/j.pep.2009.01.001
Autor:
Beverly A. Reitz, Thomas L. Emmons, Alfredo G. Tomasselli, H. David Fischer, Michael J. Bienkowski, S. Edward Lee, David Wasilko, Karl J. Mathis, Kim Jonelle Stutzman-Engwall
Publikováno v:
Protein Expression and Purification. 65:122-132
Compounds capable of stimulating soluble guanylate cyclase (sGC) activity might become important new tools to treat hypertension. While rational design of these drugs would be aided by elucidation of the sGC three-dimensional structure and molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d67ccc292e9fe1d6be21cbe94fae775
https://doi.org/10.1016/j.pep.2009.01.002
https://doi.org/10.1016/j.pep.2009.01.002
Autor:
Scott D. Hauser, Peter C. Isakson, Karl J. Mathis, Dean J. Welsch, David Paul Creely, Gwen G. Krivi
Publikováno v:
Proceedings of the National Academy of Sciences. 91:9745-9749
Leukotriene-C4 synthase (LTC4S; EC 2.5.1.37) catalyzes the committed step in the biosynthesis of the peptidoleukotrienes, which are important in the pathogenesis of asthma. Antibodies were generated to a synthetic peptide based on the partial amino a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d63b9baa98c097c24a4a4a38075c7ebb
https://doi.org/10.1073/pnas.91.21.9745
https://doi.org/10.1073/pnas.91.21.9745
Autor:
Karl J. Mathis, Madeleine H. Li, Alan M. Easton, Clara I. Villamil, Barta Thomas E, Grace E. Munie, Daniel P. Becker, Jennifer M. Williams, James R. Kiefer, Louis J. Bedell, Rico Joseph G, Susan L. Hockerman
Publikováno v:
Bioorganicmedicinal chemistry letters. 21(10)
Seeking compounds preferentially potent and selective for MMP-13, we reported in the preceding Letter on a series of hydroxamic acids with a flexible benzamide tail groups.(1a) Here, we replace the amide moiety with non-hydrolyzable heterocycles in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78ffe35bcbf17ed83e09ea89e7da6550
https://pubmed.ncbi.nlm.nih.gov/21507637
https://pubmed.ncbi.nlm.nih.gov/21507637
Autor:
Chris P. Carron, Madeleine H. Li, Daniel P. Becker, T. Sunyer, John N. Freskos, Louis J. Bedell, Boehm Terri L, Chris L. Funckes-Shippy, Decrescenzo Gary A, Clara I. Villamil, Joseph J. McDonald, Grace E. Munie, Jeffery N. Carroll, Pramod P. Mehta, Jun Yao, Brian R. Bond, Craig Swearingen, Jennifer M. Williams, Barta Thomas E, Marcia I. Heron, Dean Welsch, Karl J. Mathis, Carol Pearcy Howard, James R. Kiefer, Susan L. Hockerman, Alan M. Easton, Ying Yu
Publikováno v:
Journal of medicinal chemistry. 53(18)
α-Sulfone-α-piperidine and α-tetrahydropyranyl hydroxamates were explored that are potent inhibitors of MMP's-2, -9, and -13 that spare MMP-1, with oral efficacy in inhibiting tumor growth in mice and left-ventricular hypertrophy in rats and in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9685357a0ce79c92aebc66064d268699
https://pubmed.ncbi.nlm.nih.gov/20726512
https://pubmed.ncbi.nlm.nih.gov/20726512
Autor:
Grace E. Munie, Nicole Caspers, Alfredo G. Tomasselli, Karl J. Mathis, Jennifer M. Williams, Mark E. Schnute, Anne-Marie Malfait, Arthur J. Wittwer, Micky D. Tortorella, Scott S. Woodard, Huey-Sheng Shieh
Publikováno v:
The Journal of biological chemistry. 284(36)
Several inhibitors of a series of cis-1(S)2(R)-amino-2-indanol-based compounds were reported to be selective for the aggrecanases, ADAMTS-4 and -5 over other metalloproteases. To understand the nature of this selectivity for aggrecanases, the inhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d0a2eb43e69ba44b9b16749d11329b
https://pubmed.ncbi.nlm.nih.gov/19586907
https://pubmed.ncbi.nlm.nih.gov/19586907
Autor:
Xiong Li, Jacqueline E. Day, James R. Kiefer, Wei Huang, John I. Trujillo, Robin A. Weinberg, Li Xing, Karl J. Mathis, Kuniko K. Kretzmer, Beverley A. Reitz, Nicole Caspers, Lori Christine, Robert P. Compton, Roderick A. Stegeman, Atli Thorarensen, Ann D. Wrightstone
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(3)
The inhibition of PKC-zeta has been proposed to be a potential drug target for immune and inflammatory diseases. A series of 2-(6-phenyl-1H indazol-3-yl)-1H-benzo[d]imidazoles with initial high crossover to CDK-2 has been optimized to afford potent a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7275cc8174bc04bb0cebcacc3f8d98f3
https://pubmed.ncbi.nlm.nih.gov/19097791
https://pubmed.ncbi.nlm.nih.gov/19097791
Publikováno v:
Protein expression and purification. 60(1)
Soluble guanylate cyclase (sGC), the main target of nitric oxide (NO), is a cytosolic, heme-containing, heterodimeric enzyme that catalyzes the conversion of guanosine 5'-triphosphate (GTP) to 3,5'-cyclic guanosine monophosphate (cGMP) and pyrophosph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::333b347fc027126489975559cfbcdf7c
https://pubmed.ncbi.nlm.nih.gov/18430586
https://pubmed.ncbi.nlm.nih.gov/18430586
Autor:
Alfredo G. Tomasselli, Margaret H. Marino, Timothy E. Benson, James R. Kiefer, Huey-Sheng Shieh, Jennifer M. Williams, Joseph W. Leone, Elizabeth C. Arner, Micky D. Tortorella, Anne-Marie Malfait, Joe F. Wiese, Jeffery N. Carroll, Robert L. Hills, Karl J. Mathis
Publikováno v:
The Journal of biological chemistry. 283(3)
Aggrecanase-2 (a disintegrin and metalloproteinase with thrombospondin motifs-5 (ADAMTS-5)), a member of the ADAMTS protein family, is critically involved in arthritic diseases because of its direct role in cleaving the cartilage component aggrecan.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b14dbcacf23c170de304f5917acac697
https://pubmed.ncbi.nlm.nih.gov/17991750
https://pubmed.ncbi.nlm.nih.gov/17991750