Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Karl J Lewis"'
Autor:
Perla C. Reyes Fernandez, Christian S. Wright, Adrianna N. Masterson, Xin Yi, Tristen V. Tellman, Andrei Bonteanu, Katie Rust, Megan L. Noonan, Kenneth E. White, Karl J. Lewis, Uma Sankar, Julia M. Hum, Gregory Bix, Danielle Wu, Alexander G. Robling, Rajesh Sardar, Mary C. Farach-Carson, William R. Thompson
Publikováno v:
Biomolecules, Vol 12, Iss 12, p 1857 (2022)
Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified “tethering elements” (TEs) spanning the pericellular space of osteocytes and transmitting mechanical
Externí odkaz:
https://doaj.org/article/a1392b417754406fb1656b6685dd4912
The mTORC2 Component Rictor Is Required for Load‐Induced Bone Formation in Late‐Stage Skeletal Cells
Autor:
Karl J Lewis, Xin Yi, Christian S Wright, Emily Z Pemberton, Whitney A Bullock, William R Thompson, Alexander G Robling
Publikováno v:
JBMR Plus, Vol 4, Iss 7, Pp n/a-n/a (2020)
ABSTRACT Bone relies on mechanical cues to build and maintain tissue composition and architecture. Our understanding of bone cell mechanotransduction continues to evolve, with a few key signaling pathways emerging as vital. Wnt/β‐catenin, for exam
Externí odkaz:
https://doaj.org/article/6299d5d7b70041cf8a6f6af606efa486
Autor:
Evan G. Buettmann, Carolyn Chlebek, Carly A. Lockard, Sade W. Clayton, Karl J. Lewis, Kelsey H. Collins
Publikováno v:
Journal of Orthopaedic Research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::964841487b53d29c5e7f3ad083d8e60a
https://doi.org/10.1002/jor.25588
https://doi.org/10.1002/jor.25588
Autor:
Mitchell B. Schaffler, Mia M. Thi, David C. Spray, Macy Castaneda, James F. Boorman-Padgett, Karl J. Lewis
Publikováno v:
Journal of Visualized Experiments.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c50a5d6e03a2936a204c31390247fde3
https://doi.org/10.3791/64366
https://doi.org/10.3791/64366
Autor:
Karl J. Lewis
Publikováno v:
Connective tissue research. 63(1)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7965421b3032c4ddefa5b5f602dd07
https://pubmed.ncbi.nlm.nih.gov/34781792
https://pubmed.ncbi.nlm.nih.gov/34781792
Autor:
Daniel J. Horan, April M. Hoggatt, Hiroki Yokota, Fredrick M. Pavalko, Alexander G. Robling, Whitney A. Bullock, Karl J. Lewis, Steven Hann, Matthew L. Warman, Gabriela G. Loots, Aimy Sebastian
Publikováno v:
J Bone Miner Res
Mechanical stimulation is a key regulator of bone mass, maintenance, and turnover. Wnt signaling is a key regulator of mechanotransduction in bone, but the role of β-catenin-an intracellular signaling node in the canonical Wnt pathway-in disuse mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9447b85ff3cffdce2ca1d0fefdd85aa4
https://doi.org/10.1002/jbmr.3812
https://doi.org/10.1002/jbmr.3812
The mTORC2 Component Rictor Is Required for Load‐Induced Bone Formation in Late‐Stage Skeletal Cells
Autor:
Xin Yi, Alexander G. Robling, Whitney A. Bullock, Karl J. Lewis, Emily Z. Pemberton, Christian S. Wright, William R. Thompson
Publikováno v:
JBMR Plus
JBMR Plus, Vol 4, Iss 7, Pp n/a-n/a (2020)
JBMR Plus, Vol 4, Iss 7, Pp n/a-n/a (2020)
Bone relies on mechanical cues to build and maintain tissue composition and architecture. Our understanding of bone cell mechanotransduction continues to evolve, with a few key signaling pathways emerging as vital. Wnt/β‐catenin, for example, is e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03161aa3539297558c4b0014bfc143ee
http://europepmc.org/articles/PMC7340445
http://europepmc.org/articles/PMC7340445
Autor:
Robin M. Queen, Deana Mercer, Karl J. Lewis, James C. Iatridis, Brenda Frederick, Kharma C. Foucher, Clare M. Rimnac, Christopher J. Hernandez, Jennifer J. Westendorf, Marjolein C. H. van der Meulen, Tamara Alliston, X. Sherry Liu, Kenneth M. Kozloff, Ruth Ochia
Publikováno v:
Journal of orthopaedic research : official publication of the Orthopaedic Research SocietyREFERENCES. 38(8)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dea6920ae3e7c2a7f699f9650b161be3
https://pubmed.ncbi.nlm.nih.gov/32267012
https://pubmed.ncbi.nlm.nih.gov/32267012
Autor:
Mia M. Thi, Karl J. Lewis, Zeynep Seref-Ferlengez, Samuel Stephen, Sheldon Weinbaum, David C. Spray, Joyce Louie, Robert J. Majeska, Pamela Cabahug-Zuckerman, James F. Boorman-Padgett, Mitchell B. Schaffler, Jelena Basta-Pljakic
Publikováno v:
Bone
Microstructural adaptation of bone in response to mechanical stimuli is diminished with estrogen deprivation. Here we tested in vivo whether ovariectomy (OVX) alters the acute response of osteocytes, the principal mechanosensory cells of bone, to mec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afdaa1ba18844bc2821f38ef48d3a60a
https://doi.org/10.1016/j.bone.2021.116072
https://doi.org/10.1016/j.bone.2021.116072
Autor:
Sheldon Weinbaum, Dorra Frikha-Benayed, Samuel Stephen, Karl J. Lewis, Mitchell B. Schaffler, Mia M. Thi, Robert J. Majeska, Joyce Louie, Zeynep Seref-Ferlengez, David C. Spray
Publikováno v:
Proceedings of the National Academy of Sciences. 114:11775-11780
Osteocytes are considered to be the major mechanosensory cells of bone, but how osteocytes in vivo process, perceive, and respond to mechanical loading remains poorly understood. Intracellular calcium (Ca2+) signaling resulting from mechanical stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5827b43dffa3d49fb8783aa04061b41f
https://doi.org/10.1073/pnas.1707863114
https://doi.org/10.1073/pnas.1707863114