Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Karl J L Fernandes"'
Autor:
Melanie Loix, Sam Vanherle, Marta Turri, Stephan Kemp, Karl J. L. Fernandes, Jerome J. A. Hendriks, Jeroen F. J. Bogie
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-15 (2024)
Abstract Disturbances in the fatty acid lipidome are increasingly recognized as key drivers in the progression of various brain disorders. In this review article, we delve into the impact of Δ9 fatty acid desaturases, with a particular focus on stea
Externí odkaz:
https://doaj.org/article/d0cd345d6a534169b3d87a3b0071d96d
Autor:
Laura K. Hamilton, Paule E. H. M’Bra, Sophia Mailloux, Manon Galoppin, Anne Aumont, Karl J. L. Fernandes
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Evidence from genetic and epidemiological studies point to lipid metabolism defects in both the brain and periphery being at the core of Alzheimer’s disease (AD) pathogenesis. Previously, we reported that central inhibition of the rate-lim
Externí odkaz:
https://doaj.org/article/727f5ff5e5f646b18dbc82d5031be3e6
Autor:
Catherine-Alexandra Grégoire, David Bonenfant, Adalie Le Nguyen, Anne Aumont, Karl J L Fernandes
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e86237 (2014)
Environmental enrichment (EE) exerts powerful effects on brain physiology, and is widely used as an experimental and therapeutic tool. Typical EE paradigms are multifactorial, incorporating elements of physical exercise, environmental complexity, soc
Externí odkaz:
https://doaj.org/article/ab342410cf1849ada7e82bda161cb1bb
Autor:
Steve Lacroix, Laura K Hamilton, Alexandre Vaugeois, Stéfanny Beaudoin, Christian Breault-Dugas, Isabelle Pineau, Sébastien A Lévesque, Catherine-Alexandra Grégoire, Karl J L Fernandes
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85916 (2014)
The adult mammalian spinal cord has limited regenerative capacity in settings such as spinal cord injury (SCI) and multiple sclerosis (MS). Recent studies have revealed that ependymal cells lining the central canal possess latent neural stem cell pot
Externí odkaz:
https://doaj.org/article/1aa97cd7ab874964b5ee587b5eddf703
Autor:
Laura K. Hamilton, Gaël Moquin-Beaudry, Chenicka L. Mangahas, Federico Pratesi, Myriam Aubin, Anne Aumont, Sandra E. Joppé, Alexandre Légiot, Annick Vachon, Mélanie Plourde, Catherine Mounier, Martine Tétreault, Karl J. L. Fernandes
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/9953dc3130f340d693a49140e14e055f
Autor:
Laura K, Hamilton, Gaël, Moquin-Beaudry, Chenicka L, Mangahas, Federico, Pratesi, Myriam, Aubin, Anne, Aumont, Sandra E, Joppé, Alexandre, Légiot, Annick, Vachon, Mélanie, Plourde, Catherine, Mounier, Martine, Tétreault, Karl J L, Fernandes
Publikováno v:
Nature Communications. 13
The defining features of Alzheimer’s disease (AD) include alterations in protein aggregation, immunity, lipid metabolism, synapses, and learning and memory. Of these, lipid abnormalities are the least understood. Here, we investigate the role of St
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6299bcaaad31b69b800547b04475dc
https://doi.org/10.1038/s41467-022-29506-y
https://doi.org/10.1038/s41467-022-29506-y
Autor:
Catherine-Alexandra Grégoire, Stephanie Tobin, Brianna L. Goldenstein, Éric Samarut, Andréanne Leclerc, Anne Aumont, Pierre Drapeau, Stephanie Fulton, Karl J. L. Fernandes
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Frontiers in Molecular Neuroscience
Frontiers in Molecular Neuroscience
Environmental enrichment (EE) is a powerful stimulus of brain plasticity and is among the most accessible treatment options for brain disease. In rodents, EE is modeled using multi-factorial environments that include running, social interactions, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ccc90cde737c540a959645f93ed9ff
http://journal.frontiersin.org/article/10.3389/fnmol.2018.00126/full
http://journal.frontiersin.org/article/10.3389/fnmol.2018.00126/full
Autor:
Laura K, Hamilton, Karl J L, Fernandes
Publikováno v:
Biology of the cell. 110(1)
Neural stem cell (NSC) activity and adult neurogenesis are physiologically relevant regulators of adult brain structure, function and repair. Given these roles, the NSC impairments observed in a wide range of neurodegenerative and psychiatric conditi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78bb4b8ccef9c56bf20d30b7bf6d1544
https://pubmed.ncbi.nlm.nih.gov/28980327
https://pubmed.ncbi.nlm.nih.gov/28980327
Autor:
David R. Kaplan, Karl J. L. Fernandes, Jean G. Toma, Mahnaz Akhavan, Abbas F. Sadikot, Freda D. Miller, Fanie Barnabé-Heider
Publikováno v:
Nature Cell Biology. 3:778-784
We describe here the isolation of stem cells from juvenile and adult rodent skin. These cells derive from the dermis, and clones of individual cells can proliferate and differentiate in culture to produce neurons, glia, smooth muscle cells and adipoc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acceb41a5161658fc607249107eec9a1
https://doi.org/10.1038/ncb0901-778
https://doi.org/10.1038/ncb0901-778
Autor:
Laura K, Hamilton, Anne, Aumont, Carl, Julien, Alexandra, Vadnais, Frédéric, Calon, Karl J L, Fernandes
Publikováno v:
The European journal of neuroscience. 32(6)
Alzheimer's disease (AD) affects cognitive modalities that are known to be regulated by adult neurogenesis, such as hippocampal- and olfactory-dependent learning and memory. However, the relationship between AD-associated pathologies and alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::34264341c4d0d0522283aa85d36ef687
https://pubmed.ncbi.nlm.nih.gov/20726889
https://pubmed.ncbi.nlm.nih.gov/20726889