Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Karl J Fryxell"'
Autor:
Regina Lynn Leckie, Lauren E Oberlin, Michelle W Voss, Ruchika S Prakash, Amanda eSzabo-Reed, Laura eChaddock-Heyman, Siobhan M Phillips, Neha P Gothe, Emily eMailey, Victoria Jeanne Vieira-Potter, Stephen A Martin, Brandt D Pence, Mingkuan eLin, Raja eParasuraman, Pamela M Greenwood, Karl J Fryxell, Jeffrey eWoods, Edward eMcAuley, Arthur F Kramer, Kirk I Erickson
Publikováno v:
Frontiers in Human Neuroscience, Vol 8 (2014)
Executive function declines with age, but engaging in aerobic exercise may attenuate decline. One mechanism by which aerobic exercise may preserve executive function is through the up-regulation of brain-derived neurotropic factor (BDNF), which also
Externí odkaz:
https://doaj.org/article/9fab68a62c0a4cf693b4f3025d7bea60
Autor:
R. Logan Murphy, Laura L. Locklear, Rebecca L Walton, Alexandra D Hudson, Karl J. Fryxell, M Haris Niaz
Publikováno v:
Psychopharmacology. 238:3477-3497
Cd81 -/- (knockout) mice have previously been reported to have reduced cocaine preference and increased striatal dopamine content and dopamine turnover, but normal learning and memory in the Morris water maze. The effects of Cd81 on other behaviors a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f5a067819d115e033b71cc8d1ce78aa
https://doi.org/10.1007/s00213-021-05966-w
https://doi.org/10.1007/s00213-021-05966-w
Autor:
Laura N. Smith, Susan E. Bachus, Karl J. Fryxell, Robert F. Smith, Craig G. McDonald, Tracey L. Wheeler
Publikováno v:
Pharmacology Biochemistry and Behavior. 103:723-734
Adolescents with Attention Deficit Hyperactivity Disorder (ADHD) have higher rates of smoking than adolescents without ADHD. Since methylphenidate is the primary drug used to treat ADHD, it is likely that many adolescents are exposed to both methylph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d5362dd355e392c9be381c5214d19c1
https://doi.org/10.1016/j.pbb.2012.12.005
https://doi.org/10.1016/j.pbb.2012.12.005
Publikováno v:
Neuropharmacology. 63:582-592
Nicotine has both rewarding and aversive properties in rodents, as shown by intravenous self-administration, intracranial self-stimulation, and conditioned place preference experiments. However, high throughput models of nicotine reward have not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc66e05e35c00104f640a069d530e94c
https://doi.org/10.1016/j.neuropharm.2012.04.037
https://doi.org/10.1016/j.neuropharm.2012.04.037
Autor:
Reshma Kumar, Mingkuan Lin, Raja Parasuraman, Ramya Sundararajan, Karl J. Fryxell, Pamela M. Greenwood
Publikováno v:
Journal of Cognitive Neuroscience. 21:2139-2153
We investigated the relation between the two systems of visuospatial attention and working memory by examining the effect of normal variation in cholinergic and noradrenergic genes on working memory performance under attentional manipulation. We prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe2f82065053e920dd9a6cd733720d54
https://doi.org/10.1162/jocn.2008.21164
https://doi.org/10.1162/jocn.2008.21164
Publikováno v:
Proceedings of the National Academy of Sciences. 106:3633-3638
It is widely appreciated that neurotransmission systems interact in their effects on human cognition, but those interactions have been little studied. We used genetics to investigate pharmacological evidence of synergisms in nicotinic/muscarinic inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cc287b11db94fb179bee60c3fda9f9c
https://doi.org/10.1073/pnas.0807891106
https://doi.org/10.1073/pnas.0807891106
Publikováno v:
Biological Psychiatry. 61:56-64
Background Previous data in humans and animal models has suggested connections between anxiety, depression, smoking behavior, and nicotine dependence. The importance of these connections has been confirmed by clinical studies that led to the recent F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5deabc38b4389cbab855a61386aca7
https://doi.org/10.1016/j.biopsych.2006.03.038
https://doi.org/10.1016/j.biopsych.2006.03.038
Autor:
Amita D. Merchant, Karl J. Fryxell, Robert F. Smith, Amy K. Eppolito, Laura L. Locklear, Ko-Fei Ker, Oksana Polesskaya, Craig G. McDonald, Laura N. Smith, Tracey L. Wheeler
Publikováno v:
Neurotoxicology and Teratology. 29:126-140
Humans often start smoking during adolescence. Recent results suggest that rodents may also be particularly vulnerable to nicotine dependence during adolescence. We examined the effect of chronic nicotine exposure on gene expression profiles during a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1648a162e95d31fab7ccba5c7280d6b2
https://doi.org/10.1016/j.ntt.2006.11.005
https://doi.org/10.1016/j.ntt.2006.11.005
Publikováno v:
Stroke. 32:6-11
Background —CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy) is an inherited condition that causes repeated small-scale strokes in adults. CADASIL is caused only by mutations in the human NOTCH3 g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::86e6614420695d748508d0a5f03300b6
https://doi.org/10.1161/01.str.32.1.6
https://doi.org/10.1161/01.str.32.1.6
Autor:
Karl J. Fryxell
Publikováno v:
Trends in Genetics. 12:364-369
Gene duplication mutants arise spontaneously at a high rate in bacteria, bacteriophages, insects and mammalian cells, and are generally viable. Thus, the rate-limiting step in the evolutionary process of gene duplication and divergence was probably n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5add4c6fab664567aef1e3381766069e
https://doi.org/10.1016/s0168-9525(96)80020-5
https://doi.org/10.1016/s0168-9525(96)80020-5