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Akademický článek

On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development

Autor: Patrick J. O’Dwyer, Georgios Imanidis, Karl J. Box, Christos Reppas

Publikováno v: Pharmaceutics, Vol 12, Iss 3, p 272 (2020)

A small-scale biphasic dissolution setup and a small-scale dissolution-permeation (D-P) setup were evaluated for their usefulness in simulating the luminal precipitation of three lipophilic weak bases—dipyridamole, ketoconazole and itraconazole. Th

Externí odkaz: https://doaj.org/article/654759486b4e406f93bd46e1917a97b0

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Oral biopharmaceutics tools: recent progress from partnership through the Pharmaceutical Education and Research with Regulatory Links collaboration

Autor: Laura J. Henze, Christos Reppas, Jennifer B. Dressman, Marina Statelova, Chara Litou, Christina Pentafragka, Patrick J O'Dwyer, Karl J. Box, Brendan T. Griffin, Maria Vertzoni

Publikováno v: Journal of Pharmacy and Pharmacology. 73:437-446

ObjectivesTo summarise key contributions of the Pharmaceutical Education and Research with Regulatory Links (PEARRL) project (2016–2020) to the optimisation of existing and the development of new biopharmaceutics tools for evaluating the in vivo pe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2786ebf080a4e3efc047c84cefde61
https://doi.org/10.1093/jpp/rgaa055

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On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state

Autor: Patrick J. O’Dwyer Karl J. Box Georgios Imanidis Maria Vertzoni Christos Reppas

A small-scale two-stage biphasic system, a small-scale two-stage dissolution-permeation system, the Erweka mini-paddle apparatus, and the BioGIT system were evaluated for their usefulness in assessing the intraluminal performance of two low solubilit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______2127::088b79291a6f83c851e30699a01e388a
https://pergamos.lib.uoa.gr/uoa/dl/object/uoadl:2962522

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Applying Computational Predictions of Biorelevant Solubility Ratio Upon Self-Emulsifying Lipid-Based Formulations Dispersion to Predict Dose Number

Autor: Joseph P. O'Shea, Niklas J. Koehl, Harriet Bennett-Lenane, Karl J. Box, Patrick J O'Dwyer, Brendan T. Griffin

Publikováno v: Journal of pharmaceutical sciences. 110(1)

Computational approaches are increasingly utilised in development of bio-enabling formulations, including self-emulsifying drug delivery systems (SEDDS), facilitating early indicators of success. This study investigated if in silico predictions of dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d92dad9e59dd66159aabfa447241c8
https://pubmed.ncbi.nlm.nih.gov/33144233

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Combining biorelevant in vitro and in silico tools to investigate the in vivo performance of the amorphous solid dispersion formulation of etravirine in the fed state

Autor: Jennifer B. Dressman, Karl J. Box, David B. Turner, Edmund Kostewicz, René Holm, Martin Kuentz, Chara Litou, Nico Holmstock, Jens Ceulemans

Publikováno v: European Journal of Pharmaceutical Sciences

Introduction : In the development of bio-enabling formulations, innovative in vivo predictive tools to understand and predict the in vivo performance of such formulations are needed. Etravirine, a non-nucleoside reverse transcriptase inhibitor, is cu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1dd04f1a01df8b73f4a01e8f7595685
http://publikationen.ub.uni-frankfurt.de/files/53224/Etravirine_research_paper_local_repository.pdf

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On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development

Autor: Karl J. Box, Christos Reppas, Patrick J O'Dwyer, Georgios Imanidis

Publikováno v: Pharmaceutics
Volume 12
Issue 3
Pharmaceutics, Vol 12, Iss 3, p 272 (2020)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d2f99c790562a378e93c61779346b1

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On the usefulness of four in vitro methodologies in screening for product related differences in tacrolimus exposure after oral administration of amorphous solid dispersions with modified release characteristics in the fasted state

Autor: Georgia Tsakiridou, Patrick J. O'Dwyer, Antonios Margaritis, Karl J. Box, Maria Vertzoni, Lida Kalantzi, Christos Reppas

Publikováno v: Journal of Drug Delivery Science and Technology. 69:102990

Objective: To investigate the usefulness of four in vitro methodologies in screening for product related differences in tacrolimus exposure after oral administration of amorphous solid dispersions with modified release characteristics in the fasted s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952bf21c2d1d3431baa163236d9b6d1f
https://doi.org/10.1016/j.jddst.2021.102990

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On the usefulness of four in vitro methods in assessing the intraluminal performance of poorly soluble, ionisable compounds in the fasted state

Autor: Georgios Imanidis, Karl J. Box, Maria Vertzoni, Patrick J O'Dwyer, Christos Reppas

Publikováno v: European Journal of Pharmaceutical Sciences

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9763ad2a44a90c0d8eb82e59ca28af53
https://doi.org/10.1016/j.ejps.2021.106034

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