Zobrazeno 1 - 10
of 261
pro vyhledávání: '"Karl Herrup"'
Publikováno v:
Biomedicines, Vol 12, Iss 6, p 1327 (2024)
Alzheimer’s disease (AD) is a neurodegenerative illness with a typical age of onset exceeding 65 years of age. The age dependency of the condition led us to track the appearance of DNA damage in the frontal cortex of individuals who died with a dia
Externí odkaz:
https://doaj.org/article/c103e12aad8f419abec98b1256ce7a7d
Autor:
Hajime Takase, Gen Hamanaka, Ryo Ohtomo, Hidehiro Ishikawa, Kelly K. Chung, Emiri T. Mandeville, Josephine Lok, Myriam Fornage, Karl Herrup, Kai-Hei Tse, Eng H. Lo, Ken Arai
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
White matter damage caused by cerebral hypoperfusion is a major hallmark of subcortical ischemic vascular dementia (SIVD), which is the most common subtype of vascular cognitive impairment and dementia (VCID) syndrome. In an aging society, the number
Externí odkaz:
https://doaj.org/article/25f21b31cb26423c8c40c5188442765d
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-19 (2018)
Abstract Background Inflammation plays a critical role in accelerating the progression of neurodegenerative diseases, such as Alzheimer’s disease (AD) and ataxia telangiectasia (A-T). In A-T mouse models, LPS-induced neuroinflammation advances the
Externí odkaz:
https://doaj.org/article/eff4aa90337e4e079edfb06c9eda2732
Publikováno v:
Journal of Eye Movement Research, Vol 13, Iss 1 (2020)
Previous research has shown that exposure to Japanese gardens reduces physiological measures of stress, e.g. heart rate, in both healthy subjects and dementia patients. However, the correlation between subjects’ physiological responses and their vi
Externí odkaz:
https://doaj.org/article/02c0db9d2a904a468946d7bb509cac25
Autor:
Kiran Bhaskar, Nicole Maphis, Guixiang Xu, Nicholas H. Varvel, Olga N. Kokiko-Cochran, Jason P. Weick, Susan M. Staugaitis, Astrid Cardona, Richard M. Ransohoff, Karl Herrup, Bruce T. Lamb
Publikováno v:
Neurobiology of Disease, Vol 62, Iss , Pp 273-285 (2014)
Massive neuronal loss is a key pathological hallmark of Alzheimer's disease (AD). However, the mechanisms are still unclear. Here we demonstrate that neuroinflammation, cell autonomous to microglia, is capable of inducing neuronal cell cycle events (
Externí odkaz:
https://doaj.org/article/aa7b7a2767a347dda18b20f23efe615d
Publikováno v:
Marine Drugs, Vol 17, Iss 2, p 79 (2019)
Cell cycle reentry is a unified mechanism shared by several neurodegenerative diseases, including Alzheimer’s disease (AD) and Ataxia Telangiectasia (A-T). This phenotype is often related to neuroinflammation in the central nervous system. To mimic
Externí odkaz:
https://doaj.org/article/c26af17ecb814f2c9513aa61903a50de
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0147134 (2016)
Chronic inflammation is associated with activated microglia and reactive astrocytes and plays an important role in the pathogenesis of neurodegenerative diseases such as Alzheimer's. Both in vivo and in vitro studies have demonstrated that inflammato
Externí odkaz:
https://doaj.org/article/4a633ce214324eccbf3c4de82ac41736
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130645 (2015)
[This corrects the article DOI: 10.1371/journal.pone.0085863.].
Externí odkaz:
https://doaj.org/article/cf00689e77a44d60864bc673a1d553bf
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85863 (2014)
In ataxia-telangiectasia (A-T) the death of neurons is associated with the loss of neuronal cell cycle control. In most Atm(-/-) mouse models, however, these cell cycle anomalies are present but the phenotype of neuronal cell loss found in humans is
Externí odkaz:
https://doaj.org/article/d4b84396302e4b98910ccadebd4d459e
Autor:
Jianmin Chen, Karl Herrup
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33177 (2012)
Glutamine is the most abundant free amino acid in the human blood stream and is 'conditionally essential' to cells. Its intracellular levels are regulated both by the uptake of extracellular glutamine via specific transport systems and by its intrace
Externí odkaz:
https://doaj.org/article/02f8f41bf615464f89d70cac85e7feb6