Zobrazeno 1 - 10
of 367
pro vyhledávání: '"Karl Heinz Krause"'
Autor:
Francis Rousset, Patrick Salmon, Simon Bredl, Ophélie Cherpin, Marta Coelho, Renier Myburgh, Marco Alessandrini, Michael Perny, Marta Roccio, Roberto F. Speck, Pascal Senn, Karl Heinz Krause
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 14, Iss , Pp 351-363 (2019)
Synthetic microRNA (miRNA) minigenes (SMIGs) have a major potential for molecular therapy; however, their optimal architecture still needs to be determined. We have previously optimized the stem structure of miRNA hairpins for efficient gene knockdow
Externí odkaz:
https://doaj.org/article/9eaa2cb7bc0c4581aa060442360c4b87
Redox activation of excitatory pathways in auditory neurons as mechanism of age-related hearing loss
Autor:
Francis Rousset, German Nacher-Soler, Marta Coelho, Sten Ilmjarv, Vivianne Beatrix Christina Kokje, Antoine Marteyn, Yves Cambet, Michael Perny, Marta Roccio, Vincent Jaquet, Pascal Senn, Karl Heinz Krause
Publikováno v:
Redox Biology, Vol 30, Iss , Pp - (2020)
Age-related hearing (ARHL) loss affects a large part of the human population with a major impact on our aging societies. Yet, underlying mechanisms are not understood, and no validated therapy or prevention exists. NADPH oxidases (NOX), are important
Externí odkaz:
https://doaj.org/article/7acaa3de12cc454c88aa37a7e2e37b3e
Autor:
Sarah Garrido-Urbani, Stephane Jemelin, Christine Deffert, Stéphanie Carnesecchi, Olivier Basset, Cédric Szyndralewiez, Freddy Heitz, Patrick Page, Xavier Montet, Liliane Michalik, Jack Arbiser, Curzio Rüegg, Karl Heinz Krause, Beat A Imhof
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e14665 (2011)
Reactive oxygen species, ROS, are regulators of endothelial cell migration, proliferation and survival, events critically involved in angiogenesis. Different isoforms of ROS-generating NOX enzymes are expressed in the vasculature and provide distinct
Externí odkaz:
https://doaj.org/article/032a823d976247cfae18c310474e5fc0
Autor:
Sarah Garrido-Urbani, Stephane Jemelin, Christine Deffert, Stéphanie Carnesecchi, Olivier Basset, Cédric Szyndralewiez, Freddy Heitz, Patrick Page, Xavier Montet, Liliane Michalik, Jack Arbiser, Curzio Rüegg, Karl Heinz Krause, Beat A. Imhof
Publikováno v:
PLoS ONE, Vol 6, Iss 2 (2011)
Externí odkaz:
https://doaj.org/article/f7fc34c293ec4c64874cbe196ac53731
Autor:
Audrey Roussel-Gervais, Stéphanie Sgroi, Yves Cambet, Sylvain Lemeille, Tamara Seredenina, Karl-Heinz Krause, Vincent Jaquet
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 17 (2023)
The tropomyosin receptor kinase B (TrkB) is encoded by the NTRK2 gene. It belongs to the family of transmembrane tyrosine kinases, which have key roles in the development and maintenance of the nervous system. Brain-derived neurotrophic factor (BDNF)
Externí odkaz:
https://doaj.org/article/5490a6c7719248d6b37acd6f28691abb
Publikováno v:
Redox Biology, Vol 66, Iss , Pp 102851- (2023)
NADPH oxidases are superoxide-producing enzymes that play a role in host defense, biosynthetic pathways, as well as cellular signaling. Humans have 7 NOX isoforms (NOX1-5, DUOX1,2), while mice and rats lack NOX5 and therefore have only 6 NOX isoforms
Externí odkaz:
https://doaj.org/article/3b7cac1af87842dbb7c1b9211f1647ad
Autor:
Alexey Koval, Jiabin Xu, Nathalia Williams, Mirco Schmolke, Karl-Heinz Krause, Vladimir L. Katanaev
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 4 (2023)
ABSTRACT The Wnt signaling pathway within host cells regulates infections by several pathogenic bacteria and viruses. Recent studies suggested that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection depends on β-catenin and can b
Externí odkaz:
https://doaj.org/article/4e314ea1f7b142d99b59c67816167ade
Autor:
Aleksandra Malgorzata Siedlar, Tamara Seredenina, Anna Faivre, Yves Cambet, Marie-José Stasia, Dominik André-Lévigne, Marie-Luce Bochaton-Piallat, Brigitte Pittet-Cuénod, Sophie de Seigneux, Karl-Heinz Krause, Ali Modarressi, Vincent Jaquet
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102609- (2023)
Differentiation of fibroblasts to myofibroblasts is governed by the transforming growth factor beta (TGF-β) through a mechanism involving redox signaling and generation of reactive oxygen species (ROS). Myofibroblasts synthesize proteins of the extr
Externí odkaz:
https://doaj.org/article/507fecb164a84209b10ef09ff4779ba1
Autor:
Felix Renaudin, Didier Hannouche, Karim Oudina, Maude Gerbaix, Manon McGilligan Subilia, Joris Paccaud, Vincent Jaquet, Karl-Heinz Krause, Serge Ferrari, Thomas Laumonier
Publikováno v:
RMD Open, Vol 9, Iss 1 (2023)
Objective Low-grade inflammation plays a pivotal role in osteoarthritis (OA) through exposure to reactive oxygen species (ROS). In chondrocytes, NADPH oxidase 4 (NOX4) is one of the major ROS producers. In this study, we evaluated the role of NOX4 on
Externí odkaz:
https://doaj.org/article/c8cbeace34ae43b2ad0ce31e27257e90
Autor:
German Nacher-Soler, Antoine Marteyn, Natasha Barenzung, Stéphanie Sgroi, Karl-Heinz Krause, Pascal Senn, Francis Rousset
Publikováno v:
Frontiers in Neurology, Vol 13 (2022)
The reactive oxygen species (ROS)-generating enzyme NOX3 has recently been implicated in the pathophysiology of several acquired forms of sensorineural hearing loss, including cisplatin-, noise- and age-related hearing loss. NOX3 is highly and specif
Externí odkaz:
https://doaj.org/article/a0b63fc415a141ed9b378c83e6b2103b