Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Karl Heinonen"'
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Akademický článek
The CD40 agonist HERA-CD40L results in enhanced activation of antigen presenting cells, promoting an anti-tumor effect alone and in combination with radiotherapy
Autor: Jamie Frankish, Debayan Mukherjee, Erminia Romano, Katharina Billian-Frey, Matthias Schröder, Karl Heinonen, Christian Merz, Mauricio Redondo Müller, Christian Gieffers, Oliver Hill, Meinolf Thiemann, Jamie Honeychurch, Tim Illidge, Jaromir Sykora
Publikováno v: Frontiers in Immunology, Vol 14 (2023)
IntroductionThe ability to modulate and enhance the anti-tumor immune responses is critical in developing novel therapies in cancer. The Tumor Necrosis Factor (TNF) Receptor Super Family (TNFRSF) are potentially excellent targets for modulation which
Externí odkaz: https://doaj.org/article/3a2c8f98856e4fc4a7c38804f359c93f
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2
Akademický článek
HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality
Autor: David M. Richards, Viola Marschall, Katharina Billian-Frey, Karl Heinonen, Christian Merz, Mauricio Redondo Müller, Julian P. Sefrin, Matthias Schröder, Jaromir Sykora, Harald Fricke, Oliver Hill, Christian Gieffers, Meinolf Thiemann
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Abstract Background Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the im
Externí odkaz: https://doaj.org/article/04921d3723f8400dab5dcc210d3292d0
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3
Akademický článek
A Single-Chain-Based Hexavalent CD27 Agonist Enhances T Cell Activation and Induces Anti-Tumor Immunity
Autor: Meinolf Thiemann, David M. Richards, Karl Heinonen, Michael Kluge, Viola Marschall, Christian Merz, Mauricio Redondo Müller, Tim Schnyder, Julian P. Sefrin, Jaromir Sykora, Harald Fricke, Christian Gieffers, Oliver Hill
Publikováno v: Frontiers in Oncology, Vol 8 (2018)
Tumor necrosis factor receptor superfamily member 7 (TNFRSF7, CD27), expressed primarily by T cells, and its ligand CD27L (TNFSF7, CD70) provide co-stimulatory signals that boost T cell activation, differentiation, and survival. Agonistic stimulation
Externí odkaz: https://doaj.org/article/025eb8d7f2eb4ce1b1593f12beb4631b
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4
The Hexavalent CD40 Agonist HERA-CD40L Induces T-Cell–mediated Antitumor Immune Response Through Activation of Antigen-presenting Cells
Autor: Jaromir Sykora, Mauricio Redondo Müller, Meinolf Thiemann, Oliver Hill, David M. Richards, Christian Gieffers, Christian Merz, Karl Heinonen, Harald Fricke, Tim Schnyder, Viola Marschall
Publikováno v: Journal of Immunotherapy. 41:385-398
CD40 ligand (TNFSF5/CD154/CD40L), a member of the tumor necrosis factor (TNF) superfamily is a key regulator of the immune system. The cognate receptor CD40 (TNFRSF5) is expressed broadly on antigen-presenting cells and many tumor types, and has emer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0a8811004b002a8c10842d1f6b4e4d
https://doi.org/10.1097/cji.0000000000000246
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5
Abstract 1587: Generation and characterization of novel bispecific molecules combining single-chain-CD40L with anti-CEA, anti-CD95L or anti-PD-L1 targeting moieties
Autor: Oliver Hill, Katharina Billian-Frey, Matthias Schroeder, Christian Gieffers, Jaromir Sykora, Meinolf Thiemann, Jamie Frankish, Karl Heinonen, Mauricio Redondo-Mueller
Publikováno v: Cancer Research. 81:1587-1587
CD40 ligand is a member of the TNF superfamily (TNF-SF) and a key regulator of the immune system. Its cognate receptor CD40 is expressed on antigen-presenting cells and on many tumor types, and has emerged as an attractive target for immunological ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4346b0e723541a8ba807d33133558caf
https://doi.org/10.1158/1538-7445.am2021-1587
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6
HERA-GITRL activates T cells and promotes anti-tumor efficacy independent of FcγR-binding functionality
Autor: Oliver Hill, Christian Merz, Meinolf Thiemann, Christian Gieffers, David M. Richards, Julian P. Sefrin, Katharina Billian-Frey, Mauricio Redondo Müller, Karl Heinonen, Harald Fricke, Jaromir Sykora, Matthias Schröder, Viola Marschall
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-13 (2019)
Journal for Immunotherapy of Cancer
Background Glucocorticoid-induced TNFR-related protein (TNFRSF18, GITR, CD357), expressed by T cells, and its ligand (TNFSF18, GITRL), expressed by myeloid populations, provide co-stimulatory signals that boost T cell activity. Due to the important r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26a4544601aef382ac432bcd4c5d9ff0
https://doi.org/10.1186/s40425-019-0671-4
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7
Abstract 1076: Hexavalent HERA-CD40L induces a productive T cell-mediated anti-tumor immune response and shows superior activity in comparison to benchmark CD40 agonistic antibodies
Autor: Mauricio Redondo Müller, Katharina Billian-Frey, Matthias Schröder, Jaromir Sykora, David M. Richards, Christian Merz, Oliver Hill, Meinolf Thiemann, Julian P. Sefrin, Christian Gieffers, Karl Heinonen
Publikováno v: Cancer Research. 80:1076-1076
TNF Receptor Superfamily members (TNF-R-SF), including CD40, are key regulators of the immune system and have been immunotherapeutic targets for over 20 years. CD40 signaling serves as an important co-stimulatory signal for antigen-presenting cells (
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2801fdc6b176be3b8ae56d5c77bc5793
https://doi.org/10.1158/1538-7445.am2020-1076
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8
Abstract 4460: Novel bispecific molecules combining HERA-CD40L with anti-CEA or with anti-PD-L1 for targeting
Autor: Meinolf Thiemann, Oliver Hill, Jaromir Sykora, Christian Gieffers, Karl Heinonen, Christian Merz, Julian P. Sefrin, Katharina Billian-Frey, David M. Richards, Mauricio Redondo Müller, Matthias Schröder
Publikováno v: Cancer Research. 80:4460-4460
CD40 ligand is a member of the TNF superfamily and a key regulator of the immune system. Its cognate receptor CD40 is expressed on antigen-presenting cells and on many tumor types, and has emerged as an attractive target for immunological cancer trea
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b1688ed3c12cec5986293aa35ef50db
https://doi.org/10.1158/1538-7445.am2020-4460
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10
Abstract 4845: HERA-CD27L, a true CD27 agonist, is a hexavalent CD27 ligand that enhances T cell activation and induces potent anti-tumor immunity
Autor: Christian Gieffers, Mauricio Redondo Müller, Jaromir Sykora, Karl Heinonen, Harald Fricke, Meinolf Thiemann, Katharina Billian-Frey, Christian Merz, Julian P. Sefrin, Matthias Schröder, David M. Richards, Oliver Hill, Viola Marschall
Publikováno v: Cancer Research. 79:4845-4845
Agonistic stimulation of TNFRSF members like CD27 is a promising strategy to boost anti-tumor responses. Although antibodies are effective inhibitors of signaling, they have shown minimal agonistic activity due to their limited binding domains, flexi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6692d8a0b970a37a27f3fbbc82fb11d0
https://doi.org/10.1158/1538-7445.am2019-4845
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