Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Karl Haslam"'
Publikováno v:
Case Reports in Hematology, Vol 2018 (2018)
Although transformation of the myeloproliferative neoplasms (MPNs) to acute myeloid leukemia (AML) is well documented, development of an MPN in patients previously treated for, and in remission from, AML is exceedingly rare. A case is described in wh
Externí odkaz:
https://doaj.org/article/1127949d8f1a45c592e03b2856472f7a
Autor:
Stephen E Langabeer, Karl Haslam
Publikováno v:
Journal of Clinical and Diagnostic Research, Vol 11, Iss 4, p EL01 (2017)
Externí odkaz:
https://doaj.org/article/244c25083bf044f3833ad8ccd45b1ef0
Autor:
Mireille Crampe, Karl Haslam, Emma Groarke, Eileen Kelleher, Derville O’Shea, Eibhlin Conneally, Stephen E. Langabeer
Publikováno v:
Case Reports in Hematology, Vol 2017 (2017)
A minority of chronic myeloid leukemia patients (CML) express a variety of atypical BCR-ABL1 fusion variants and, of these, the e6a2 BCR-ABL1 fusion is generally associated with an aggressive disease course. Progression of CML to blast crisis is asso
Externí odkaz:
https://doaj.org/article/63d3fbb0e30d40d489811df650453fd7
Autor:
Stephen E. Langabeer, Karl Haslam, David O’Brien, Johanna Kelly, Claire Andrews, Ciara Ryan, Richard Flavin, Patrick J. Hayden, Christopher L. Bacon
Publikováno v:
Case Reports in Hematology, Vol 2016 (2016)
The development of acute lymphoblastic leukemia in an existing myeloproliferative neoplasm is rare with historical cases unable to differentiate between concomitant malignancies or leukemic transformation. Molecular studies of coexisting JAK2 V617F-p
Externí odkaz:
https://doaj.org/article/6e7474b03b2c455185d6e7c45669da52
Autor:
Stephen E. Langabeer, James Nolan, Karl Haslam, Lindsey Clarke, Richard Flavin, Eibhlin Conneally
Publikováno v:
Case Reports in Hematology, Vol 2015 (2015)
Monitoring of the JAK2 V617F allele burden in myeloproliferative neoplasms after allogeneic stem cell transplantation is useful to determine levels of residual disease and has the potential to detect early relapse and guide subsequent clinical interv
Externí odkaz:
https://doaj.org/article/b8855ef5b84240e1ba37882dfb928e26
Autor:
Karl Haslam, Stephen E. Langabeer, Johanna Kelly, Natasha Coen, Niamh M. O’Connell, Eibhlin Conneally
Publikováno v:
Case Reports in Hematology, Vol 2012 (2012)
Hematopoietic myeloproliferative neoplasms (MPNS) with rearrangements of the receptor tyrosine kinase FGFR1 gene, located on chromosome 8p11, are uncommon and associated with diverse presentations such as atypical chronic myeloid leukemia, acute myel
Externí odkaz:
https://doaj.org/article/84f9c065d1744312a697f3360f4d84a6
Autor:
Stephen E. Langabeer, Johanna Kelly, Karl Haslam, John Quinn, Eibhlin Conneally, Ruth Morrell
Publikováno v:
Clinical and Translational Oncology. 20:420-423
Chronic neutrophilic leukemia is a rare form of myeloproliferative neoplasm characterized by mature neutrophil hyperleukocytosis. The majority of patients harbor somatic mutations of CSF3R gene and are potentially amenable to targeted therapy with JA
Publikováno v:
Hematology/Oncology and Stem Cell Therapy, Vol 10, Iss 2, Pp 85-88 (2017)
Molecular monitoring of BCR–ABL1 transcript levels using quantitative polymerase chain reaction is an essential part of the modern management of chronic myeloid leukemia patients treated with tyrosine kinase inhibitors. Establishing the diagnostic
Autor:
Ciara Mullen, Janusz Krawczyk, Sinead Lahiff, Michael O'Dwyer, Evelyn Keady, Moutaz A Abdelrahman, Thomas Keaney, Stehpen Langabeer, Amjad Hayat, Karl Haslam, Terry J. Smith, Louise O'Connor, Barry Glynn, Margaret Murray, Melanie J. Percy
Publikováno v:
Journal of Clinical Pathology. 70:662-668
Aims Somatic insertions/deletions in exon 9 of the calreticulin gene have been identified in patients with essential thrombocythemia and primary myelofibrosis. Over 55 mutations have been discovered, 80% of which consist of either type 1 52-bp deleti
Autor:
Mireille Crampe, Eibhlin Conneally, Emma Groarke, Karl Haslam, Derville O'Shea, Eileen Kelleher, Stephen E. Langabeer
Publikováno v:
Case Reports in Hematology
Case Reports in Hematology, Vol 2017 (2017)
Case Reports in Hematology, Vol 2017 (2017)
A minority of chronic myeloid leukemia patients (CML) express a variety of atypicalBCR-ABL1fusion variants and, of these, the e6a2BCR-ABL1fusion is generally associated with an aggressive disease course. Progression of CML to blast crisis is associat