Zobrazeno 1 - 8 of 8 pro vyhledávání: '"Karl H. Nollstadt"'
1
Lipopeptide antifungal agents: Amine conjugates of the semi-synthetic pneumocandins L-731,373 and L-733,560
Autor: Catherine James, Richard Hajdu, Randy Thompson, Jean A. Marrinan, Bartizal Kenneth F, James M. Balkovec, George K. Abruzzo, Robert A. Zambias, Karl H. Nollstadt
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 7:2021-2026
Amine conjugates of the semi-synthetic 1,3-β-(D)-glucan synthesis inhibitors L-731,373 (3) and L-733,560 (4) were prepared and evaluated for in vitro and in vivo antifungal activity. Tricationic analogs were more potent than the dicationic which wer
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e9dc5e9fe51f63e066f2b9349c3a568
https://doi.org/10.1016/s0960-894x(97)00359-4
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2
Antifungal lipopeptides: Structure-activity relationships of 3-hydroxyglutamine-modified pneumocandin B0 derivatives
Autor: George K. Abruzzo, Robert A. Zambias, Bartizal Kenneth F, Jean A. Marrinan, Catherine James, Milton L. Hammond, Karl H. Nollstadt, Cameron M. Douglas, James M. Balkovec
Publikováno v: Bioorganic & Medicinal Chemistry Letters. 5:2357-2362
Selective methanolysis or dehydration followed by reduction of the 3-hydroxyglutamine residue of pneumocandin B0 (1) or its dideoxy analog 5 (L-692,289) gave the methyl 3-hydroxyglutamate and 3-hydroxyornithine analogs 6 and 9, respectively. Further
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f66f9396fc53dac00eea23cf3ad4a8a9
https://doi.org/10.1016/0960-894x(95)00407-k
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4
Treatment of Pneumocystis carinii pneumonia with 1,3-beta-glucan synthesis inhibitors
Autor: Karl H. Nollstadt, M. A. Romancheck, Robert E. Schwartz, Kenneth E. Wilson, Vanmiddlesworth Frank L, Mervyn J. Turner, L. A. Pittarelli, Robert A. Fromtling, Dennis M. Schmatz
Publikováno v: Proceedings of the National Academy of Sciences. 87:5950-5954
Pneumocystis carinii pneumonia is a major cause of death in AIDS patients in the United States. The presently available treatments have limited use due to a high incidence of adverse reactions. Therefore, there is an urgent need for a safer method fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a1fd413622cdb5df7bf1339f2349743
https://doi.org/10.1073/pnas.87.15.5950
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5
Use of beta-1,3-glucan-specific antibody to study the cyst wall of Pneumocystis carinii and effects of pneumocandin B0 analog L-733,560
Autor: Dennis M. Schmatz, H Fujioka, M Aikawa, M A Powles, Karl H. Nollstadt
Publikováno v: Antimicrobial agents and chemotherapy. 38(10)
A new class of promising antipneumocystis agents, cyclic lipopeptide pneumocandin analogs, has been shown to effectively prevent Pneumocystis carinii cyst development in murine models. These compounds are believed to inhibit the biosynthesis of beta-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b5e366558eb679cf6b6f4f6080fe170
https://pubmed.ncbi.nlm.nih.gov/7840554
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6
L-687,781, a new member of the papulacandin family of beta-1,3-D-glucan synthesis inhibitors. I. Fermentation, isolation, and biological activity
Autor: Mary Nallin Omstead, George M. Garrity, Marcia Zweerink, Susan S. Honeycutt, Gerald F. Bills, Kenneth E. Wilson, Dennis M. Schmatz, Robert A. Fromtling, Ken Bartizal, Vanmiddlesworth Frank L, Karl H. Nollstadt
Publikováno v: The Journal of antibiotics. 44(1)
A new β-1, 3-D-glucan synthesis inhibitor, L-687, 781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687, 781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c3ac4d409415f47bd92a97dd4ad5c43
https://pubmed.ncbi.nlm.nih.gov/2001985
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7
Potential of the sulfobetaine detergent zwittergent 3-12 as a desorbing agent in biospecific and bioselective affinity chromatography
Autor: Anne Gurnett, Karl H. Nollstadt, Mark J. Gnozzio, Mark S. Crane, Mervyn J. Turner, Dennis M. Schmatz, Yashwant D. Karkhanis
Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 497:87-100
The isolation in our laboratories of several antigens of interest from sporulated oocysts of Eimeria species by bioselective adsorption on matrices containing immobilized antigen-specific immunoglobulins IgG was initially unsuccessful. The preparatio
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80fe36c27035df94defbd7e5cb87b144
https://doi.org/10.1016/0378-4347(89)80008-8
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8
Anti-idiotypic antibody with potential use as an Eimeria tenella sporozoite antigen surrogate for vaccination of chickens against coccidiosis
Autor: Balbir S. Bhogal, E B Jacobson, Yashwant D. Karkhanis, Dennis M. Schmatz, Karl H. Nollstadt
Publikováno v: Infection and immunity. 56(5)
Anti-idiotypic antibodies were raised in rabbits against four monoclonal antibodies with specificity for the surface antigenic determinants of Eimeria tenella sporozoites, the infective stage of the coccidial parasite. Two of the monoclonal antibodie
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59be0f18f6d8660d08a6cf80f5f6d287
https://pubmed.ncbi.nlm.nih.gov/3258583
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