Zobrazeno 1 - 10 of 296 pro vyhledávání: '"Karl H, Plate"'
1
Akademický článek
DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma
Autor: Pinar Cakmak, Philipp Jurmeister, Iris Divé, Pia S. Zeiner, Joachim P. Steinbach, Tim R. Fenton, Karl H. Plate, Marcus Czabanka, Patrick N. Harter, Katharina J. Weber
Publikováno v: Clinical Epigenetics, Vol 16, Iss 1, Pp 1-17 (2024)
Abstract Background Giant cell (gc)-enriched glioblastoma (gcGB) represents a distinct histological variant of isocitrate dehydrogenase wild-type adult-type glioblastoma with notable enlarged mono- or multinuclear tumor cells. While some studies sugg
Externí odkaz: https://doaj.org/article/8526f144477745d7a6ce35afef5ef37a
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2
Akademický článek
Wnt/β-Catenin-Signaling Modulates Megakaryopoiesis at the Megakaryocyte-Erythrocyte Progenitor Stage in the Hematopoietic System
Autor: Burak H. Yalcin, Jadranka Macas, Eliza Wiercinska, Patrick N. Harter, Malak Fawaz, Tessa Schmachtel, Ilaria Ghiro, Ewa Bieniek, Djuro Kosanovic, Sonja Thom, Marcus Fruttiger, Makoto M. Taketo, Ralph T. Schermuly, Michael A. Rieger, Karl H. Plate, Halvard Bonig, Stefan Liebner
Publikováno v: Cells, Vol 12, Iss 23, p 2765 (2023)
The bone marrow (BM) hematopoietic system (HS) gives rise to blood cells originating from hematopoietic stem cells (HSCs), including megakaryocytes (MKs) and red blood cells (erythrocytes; RBCs). Many steps of the cell-fate decision remain to be eluc
Externí odkaz: https://doaj.org/article/5c1864d15d2e4f4aa6d34637c384b43b
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3
Akademický článek
The immune suppressive microenvironment affects efficacy of radio‐immunotherapy in brain metastasis
Autor: Katja Niesel, Michael Schulz, Julian Anthes, Tijna Alekseeva, Jadranka Macas, Anna Salamero‐Boix, Aylin Möckl, Timm Oberwahrenbrock, Marco Lolies, Stefan Stein, Karl H Plate, Yvonne Reiss, Franz Rödel, Lisa Sevenich
Publikováno v: EMBO Molecular Medicine, Vol 13, Iss 5, Pp 1-19 (2021)
Abstract The tumor microenvironment in brain metastases is characterized by high myeloid cell content associated with immune suppressive and cancer‐permissive functions. Moreover, brain metastases induce the recruitment of lymphocytes. Despite thei
Externí odkaz: https://doaj.org/article/00137b811f904876a7198d982dadfa0c
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4
Akademický článek
DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma
Autor: Bastian Schilling, Sascha Tierling, Katharina Filipski, Michael Scherer, Kim N. Zeiner, Andreas Bucher, Johannes Kleemann, Philipp Jurmeister, Tabea I. Hartung, Markus Meissner, Karl H. Plate, Tim R. Fenton, Pia S. Zeiner, Patrick N. Harter
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 7 (2021)
Background Therapies based on targeting immune checkpoints have revolutionized the treatment of metastatic melanoma in recent years. Still, biomarkers predicting long-term therapy responses are lacking.Methods A novel approach of reference-free decon
Externí odkaz: https://doaj.org/article/ab979c45047c46cd8cb514714ad3742b
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5
The endothelial-enriched lncRNA LINC00607 mediates angiogenic function
Autor: Frederike Boos, James A. Oo, Timothy Warwick, Stefan Günther, Judit Izquierdo Ponce, Melina Lopez, Diba Rafii, Giulia Buchmann, Minh Duc Pham, Zahraa S. Msheik, Tianfu Li, Sandra Seredinski, Shaza Haydar, Sepide Kashefiolasl, Karl H. Plate, Rüdiger Behr, Matthias Mietsch, Jaya Krishnan, Soni S. Pullamsetti, Sofia-Iris Bibli, Rabea Hinkel, Andrew H. Baker, Reinier A. Boon, Marcel H. Schulz, Ilka Wittig, Francis J. Miller, Ralf P. Brandes, Matthias S. Leisegang
Publikováno v: Basic Research in Cardiology, 118(1):5. Springer
Boos, F, Oo, J A, Warwick, T, Günther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic research in cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Boos, F, Oo, J A, Warwick, T, G?nther, S, Izquierdo Ponce, J, Lopez, M, Rafii, D, Buchmann, G, Pham, M D, Msheik, Z S, Li, T, Seredinski, S, Haydar, S, Kashefiolasl, S, Plate, K H, Behr, R D, Mietsch, M, Krishnan, J, Pullamsetti, S S, Bibli, S-I, Hinkel, R, Baker, A H, Boon, R A, Schulz, M H, Wittig, I, Miller, F J, Brandes, R P & Leisegang, M S 2023, ' The endothelial-enriched lncRNA LINC00607 mediates angiogenic function ', Basic Research in Cardiology, vol. 118, no. 1, 5 . https://doi.org/10.1007/s00395-023-00978-3
Basic Research in Cardiology, 118(1):5. D. Steinkopff-Verlag
Long non-coding RNAs (lncRNAs) can act as regulatory RNAs which, by altering the expression of target genes, impact on the cellular phenotype and cardiovascular disease development. Endothelial lncRNAs and their vascular functions are largely undefin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ebbb1adb912075138984c27d421e77e
https://doi.org/10.1007/s00395-023-00978-3
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7
Immuno-PET Imaging of Tumour PD-L1 Expression in Glioblastoma
Autor: Kramer-Marek, Gitanjali Sharma, Marta C. Braga, Chiara Da Pieve, Wojciech Szopa, Tatjana Starzetz, Karl H. Plate, Wojciech Kaspera, Gabriela
Publikováno v: Cancers; Volume 15; Issue 12; Pages: 3131
There is no established method to assess the PD-L1 expression in brain tumours. Therefore, we investigated the suitability of affibody molecule (ZPD-L1) radiolabelled with F-18 (Al18F) and Ga-68 to measure the expression of PD-L1 in xenograft mouse m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=multidiscipl::2d8f61801ad86874d6ba5ee2e54ffa03
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