Zobrazeno 1 - 10
of 170
pro vyhledávání: '"Karl G, Wagner"'
Publikováno v:
International Journal of Pharmaceutics: X, Vol 6, Iss , Pp 100222- (2023)
As performance of ternary amorphous solid dispersions (ASDs) depends on the solid-state characteristics and polymer mixing, a comprehensive understanding of synergistic interactions between the polymers in regard of dissolution enhancement of poorly
Externí odkaz:
https://doaj.org/article/55f38ad821f544fc9eb6772daffec688
Autor:
Katharina Dauer, Kevin Kayser, Felix Ellwanger, Achim Overbeck, Arno Kwade, Heike P. Karbstein, Karl G. Wagner
Publikováno v:
International Journal of Pharmaceutics: X, Vol 6, Iss , Pp 100196- (2023)
Understanding of generation, extent and location of thermomechanical stress in small-scale (< 3 g) ram and twin-screw melt-extrusion is crucial for mechanistic correlations to the stability of protein particles (lysozyme and BSA) in PEG-matrices. The
Externí odkaz:
https://doaj.org/article/49d3b690b008401ab896548ce704099d
Autor:
Issraa Al-Obaidi, Anna K. Krome, Karl G. Wagner, Kenneth Pfarr, Annette C. Kuesel, Hannah K. Batchelor
Publikováno v:
Parasites & Vectors, Vol 15, Iss 1, Pp 1-22 (2022)
Abstract It is recognised that paediatric indications and age-appropriate formulations are required to ensure that paediatric populations receive appropriate pharmacotherapeutic treatment. The lack of information on dosing, efficacy and safety data (
Externí odkaz:
https://doaj.org/article/cb081ec4d0ac400c810988dfbaf38ade
Publikováno v:
Pharmaceutics, Vol 16, Iss 4, p 553 (2024)
Fused deposition modeling (FDM) is a rather new technology in the production of personalized dosage forms. The melting and printing of polymer–active pharmaceutical ingredient (API)—mixtures can be used to produce oral dosage forms with different
Externí odkaz:
https://doaj.org/article/3c55bd2ff680481eaf8e45634bcc156a
Autor:
Tim Becker, Jan Heitkötter, Anna K. Krome, Andrea Schiefer, Kenneth Pfarr, Alexandra Ehrens, Miriam Grosse, Birthe Sandargo, Ingo Stammberger, Marc Stadler, Marc P. Hübner, Stefan Kehraus, Achim Hoerauf, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 16, Iss 3, p 386 (2024)
Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates vehicle screening for or
Externí odkaz:
https://doaj.org/article/67c81d037ce842dc8ccd3f679297af6f
Publikováno v:
International Journal of Pharmaceutics: X, Vol 4, Iss , Pp 100115- (2022)
A current trend in the development of amorphous solid dispersions (ASDs) is the combination of two polymers for synergistic enhancement in supersaturation of poorly soluble drugs. We investigated the supersaturation potential of celecoxib (CXB) using
Externí odkaz:
https://doaj.org/article/17388f6ce75d4d6f88c0ec338fef96af
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1978 (2023)
Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passiv
Externí odkaz:
https://doaj.org/article/5f72874ba88d4fa29fb30d017eaf7e79
Autor:
Katharina Dauer, Karl G. Wagner
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 723 (2023)
Hot-melt extrusion (HME) is used for the production of solid protein formulations mainly for two reasons: increased protein stability in solid state and/or long-term release systems (e.g., protein-loaded implants). However, HME requires considerable
Externí odkaz:
https://doaj.org/article/740cb299186a42759453020aec0a4e80
Publikováno v:
Pharmaceutics, Vol 15, Iss 3, p 764 (2023)
Spray drying is one of the most frequently used solvent-based processes for manufacturing amorphous solid dispersions (ASDs). However, the resulting fine powders usually require further downstream processing when intended for solid oral dosage forms.
Externí odkaz:
https://doaj.org/article/a284073bd6cd41e496d7ae1563a9cb06
Autor:
Bashar Ibraheem, Karl G. Wagner
Publikováno v:
International Journal of Pharmaceutics: X, Vol 3, Iss , Pp 100075- (2021)
Enabling formulations often depend on functional excipients. However, the question remains whether excipients regarded as standard establish similar interactions and subsequently improvement of solubility when employed at unusual manufacturing proces
Externí odkaz:
https://doaj.org/article/01b46d2bc41a4f59bb2645df91c3f63a