Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Karl F. Hoffmann"'
Autor:
Iain W. Chalmers, Christoph Grunau, Josephine Forde-Thomas, Karl F. Hoffmann, Andrea Brancale, Cassandra A. Celatka, Gilda Padalino, Jay H. Kalin, Hugh Y. Rienhoff Jr., Damien Lassalle, Philip A. Cole
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: Schistosoma mansoni, a parasitic worm species responsible for the neglected tropical disease schistosomiasis, undergoes strict developmental regulation of gene expression that is carefully controlled by both genetic and epigenetic process
Externí odkaz:
https://doaj.org/article/4dd3f4ccaedf4ebd9cfa3454b89491e8
Autor:
Ruby White, Javier Sotillo, María Eugenia Ancarola, Anne Borup, Anders Toftegaard Boysen, Paul J. Brindley, Edit I. Buzás, Serena Cavallero, Sujittra Chaiyadet, Iain W. Chalmers, Marcela A. Cucher, Maude Dagenais, Chelsea N. Davis, Eileen Devaney, Maria A. Duque‐Correa, Ramon Marc Eichenberger, Santiago Fontenla, Thomas A. Gasan, Cornelis H. Hokke, Maja Kosanovic, Marije E. Kuipers, Thewarach Laha, Alex Loukas, Rick M. Maizels, Antonio Marcilla, Hynek Mazanec, Russell M. Morphew, Kyriaki Neophytou, Linh Thuy Nguyen, Esther Nolte‐‘t Hoen, Michael Povelones, Mark W. Robinson, Alicia Rojas, Irma Schabussova, Hermelijn H. Smits, Sivapong Sungpradit, Lucienne Tritten, Bradley Whitehead, Amin Zakeri, Peter Nejsum, Amy H. Buck, Karl F. Hoffmann
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 1, Pp n/a-n/a (2023)
Abstract Over the last decade, research interest in defining how extracellular vesicles (EVs) shape cross‐species communication has grown rapidly. Parasitic helminths, worm species found in the phyla Nematoda and Platyhelminthes, are well‐recogni
Externí odkaz:
https://doaj.org/article/46a18460ff6e4def83a43ae02a7ed46f
Autor:
Kate A. Rawlinson, Adam J. Reid, Zhigang Lu, Patrick Driguez, Anna Wawer, Avril Coghlan, Geetha Sankaranarayanan, Sarah K. Buddenborg, Carmen Diaz Soria, Catherine McCarthy, Nancy Holroyd, Mandy Sanders, Karl F. Hoffmann, David Wilcockson, Gabriel Rinaldi, Matthew Berriman
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-21 (2021)
Abstract Background The consequences of the earth’s daily rotation have led to 24-h biological rhythms in most organisms. Even some parasites are known to have daily rhythms, which, when in synchrony with host rhythms, can optimise their fitness. U
Externí odkaz:
https://doaj.org/article/9c514beb10074835b2b16a2af319d0f5
Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
Autor:
Anand Chakroborty, Deiniol R. Pritchard, Marc E. Bouillon, Anna Cervi, Rolf Kraehenbuehl, Charlotte Wild, Caroline Fenn, Peter Holdsworth, Colin Capner, Gilda Padalino, Josephine E. Forde-Thomas, Joseph Payne, Brendan G. Smith, Maggie Fisher, Martina Lahmann, Mark S. Baird, Karl F. Hoffmann
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1869 (2023)
Infection with Fasciola hepatica (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic potential of
Externí odkaz:
https://doaj.org/article/6e8ca26b7c334320af200daf96523567
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
More than a billion people are infected with parasitic worms, including nematodes, such as hookworms, and flatworms, such as blood flukes. Few drugs are available to treat worm infections, but high-throughput screening approaches hold promise to iden
Externí odkaz:
https://doaj.org/article/e3082db7b8294ed899c342fca94eeb51
Autor:
Gilda Padalino, Avril Coghlan, Giampaolo Pagliuca, Josephine E. Forde-Thomas, Matthew Berriman, Karl F. Hoffmann
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1359 (2023)
Schistosomiasis is one of the most important neglected tropical diseases. Until an effective vaccine is registered for use, the cornerstone of schistosomiasis control remains chemotherapy with praziquantel. The sustainability of this strategy is at s
Externí odkaz:
https://doaj.org/article/45e27b46d0fb4961ac6c0c9f61f8ecce
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 559-570 (2018)
Schistosomiasis endangers the lives of greater than 200 million people every year and is predominantly controlled by a single class chemotherapy, praziquantel (PZQ). Development of PZQ replacement (to combat the threat of PZQ insensitivity/resistance
Externí odkaz:
https://doaj.org/article/c2d48592aaed42c3a4575dd70e76d802
Autor:
Helen L. Whiteland, Anand Chakroborty, Josephine E. Forde-Thomas, Alessandra Crusco, Alan Cookson, Jackie Hollinshead, Caroline A. Fenn, Barbara Bartholomew, Peter A. Holdsworth, Maggie Fisher, Robert J. Nash, Karl F. Hoffmann
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 465-474 (2018)
Two economically and biomedically important platyhelminth species, Fasciola hepatica (liver fluke) and Schistosoma mansoni (blood fluke), are responsible for the neglected tropical diseases (NTDs) fasciolosis and schistosomiasis. Due to the absence o
Externí odkaz:
https://doaj.org/article/d7538bd8d6a54de3a201e4bbc39ca081
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Background: Schistosomiasis, caused by infection with blood fluke schistosomes, is a neglected tropical disease of considerable importance in resource-poor communities throughout the developing world. In the absence of an immunoprophylactic vaccine a
Externí odkaz:
https://doaj.org/article/31cf05d82be2454fa2e8fe12662ea693
Publikováno v:
Wellcome Open Research, Vol 5 (2020)
Background: Schistosomiasis, caused by infection with blood fluke schistosomes, is a neglected tropical disease of considerable importance in resource-poor communities throughout the developing world. In the absence of an immunoprophylactic vaccine a
Externí odkaz:
https://doaj.org/article/a58929e082ec4bc98f60c5c9bf0d4000