Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Karl F, Hoffmann"'
Autor:
Iain W. Chalmers, Christoph Grunau, Josephine Forde-Thomas, Karl F. Hoffmann, Andrea Brancale, Cassandra A. Celatka, Gilda Padalino, Jay H. Kalin, Hugh Y. Rienhoff Jr., Damien Lassalle, Philip A. Cole
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: Schistosoma mansoni, a parasitic worm species responsible for the neglected tropical disease schistosomiasis, undergoes strict developmental regulation of gene expression that is carefully controlled by both genetic and epigenetic process
Externí odkaz:
https://doaj.org/article/4dd3f4ccaedf4ebd9cfa3454b89491e8
Autor:
Ruby White, Javier Sotillo, María Eugenia Ancarola, Anne Borup, Anders Toftegaard Boysen, Paul J. Brindley, Edit I. Buzás, Serena Cavallero, Sujittra Chaiyadet, Iain W. Chalmers, Marcela A. Cucher, Maude Dagenais, Chelsea N. Davis, Eileen Devaney, Maria A. Duque‐Correa, Ramon Marc Eichenberger, Santiago Fontenla, Thomas A. Gasan, Cornelis H. Hokke, Maja Kosanovic, Marije E. Kuipers, Thewarach Laha, Alex Loukas, Rick M. Maizels, Antonio Marcilla, Hynek Mazanec, Russell M. Morphew, Kyriaki Neophytou, Linh Thuy Nguyen, Esther Nolte‐‘t Hoen, Michael Povelones, Mark W. Robinson, Alicia Rojas, Irma Schabussova, Hermelijn H. Smits, Sivapong Sungpradit, Lucienne Tritten, Bradley Whitehead, Amin Zakeri, Peter Nejsum, Amy H. Buck, Karl F. Hoffmann
Publikováno v:
Journal of Extracellular Vesicles, Vol 12, Iss 1, Pp n/a-n/a (2023)
Abstract Over the last decade, research interest in defining how extracellular vesicles (EVs) shape cross‐species communication has grown rapidly. Parasitic helminths, worm species found in the phyla Nematoda and Platyhelminthes, are well‐recogni
Externí odkaz:
https://doaj.org/article/46a18460ff6e4def83a43ae02a7ed46f
Autor:
Kate A. Rawlinson, Adam J. Reid, Zhigang Lu, Patrick Driguez, Anna Wawer, Avril Coghlan, Geetha Sankaranarayanan, Sarah K. Buddenborg, Carmen Diaz Soria, Catherine McCarthy, Nancy Holroyd, Mandy Sanders, Karl F. Hoffmann, David Wilcockson, Gabriel Rinaldi, Matthew Berriman
Publikováno v:
BMC Biology, Vol 19, Iss 1, Pp 1-21 (2021)
Abstract Background The consequences of the earth’s daily rotation have led to 24-h biological rhythms in most organisms. Even some parasites are known to have daily rhythms, which, when in synchrony with host rhythms, can optimise their fitness. U
Externí odkaz:
https://doaj.org/article/9c514beb10074835b2b16a2af319d0f5
Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
Autor:
Anand Chakroborty, Deiniol R. Pritchard, Marc E. Bouillon, Anna Cervi, Rolf Kraehenbuehl, Charlotte Wild, Caroline Fenn, Peter Holdsworth, Colin Capner, Gilda Padalino, Josephine E. Forde-Thomas, Joseph Payne, Brendan G. Smith, Maggie Fisher, Martina Lahmann, Mark S. Baird, Karl F. Hoffmann
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1869 (2023)
Infection with Fasciola hepatica (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic potential of
Externí odkaz:
https://doaj.org/article/6e8ca26b7c334320af200daf96523567
Publikováno v:
Wellcome Open Research, Vol 7 (2022)
More than a billion people are infected with parasitic worms, including nematodes, such as hookworms, and flatworms, such as blood flukes. Few drugs are available to treat worm infections, but high-throughput screening approaches hold promise to iden
Externí odkaz:
https://doaj.org/article/e3082db7b8294ed899c342fca94eeb51
Autor:
Gilda Padalino, Avril Coghlan, Giampaolo Pagliuca, Josephine E. Forde-Thomas, Matthew Berriman, Karl F. Hoffmann
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1359 (2023)
Schistosomiasis is one of the most important neglected tropical diseases. Until an effective vaccine is registered for use, the cornerstone of schistosomiasis control remains chemotherapy with praziquantel. The sustainability of this strategy is at s
Externí odkaz:
https://doaj.org/article/45e27b46d0fb4961ac6c0c9f61f8ecce
Autor:
Benjamin J Hulme, Kathrin K Geyer, Josephine E Forde-Thomas, Gilda Padalino, Dylan W Phillips, Wannaporn Ittiprasert, Shannon E Karinshak, Victoria H Mann, Iain W Chalmers, Paul J Brindley, Cornelis H Hokke, Karl F Hoffmann
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1009828 (2022)
α-galactosidase (α-GAL) and α-N-acetylgalactosaminidase (α-NAGAL) are two glycosyl hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on proteins and lipids. Mutations in the human genes encoding either en
Externí odkaz:
https://doaj.org/article/05828ee02d5c4a1e99b9770422f25c16
Autor:
Thomas A Gasan, Marije E Kuipers, Grisial H Roberts, Gilda Padalino, Josephine E Forde-Thomas, Shona Wilson, Jakub Wawrzyniak, Edridah M Tukahebwa, Karl F Hoffmann, Iain W Chalmers
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009981 (2021)
Extracellular Vesicles (EVs) are an integral component of cellular/organismal communication and have been found in the excreted/secreted (ES) products of both protozoan and metazoan parasites. Within the blood fluke schistosomes, EVs have been isolat
Externí odkaz:
https://doaj.org/article/b2621b7e6e32434c869297e253311374
Autor:
Nicola Caldwell, Rana Afshar, Beatriz Baragaña, Amaya L. Bustinduy, Conor R. Caffrey, James J. Collins, Daniela Fusco, Amadou Garba, Mark Gardner, Mireille Gomes, Karl F. Hoffmann, Michael Hsieh, Nathan C. Lo, Case W. McNamara, Justin Komguep Nono, Gilda Padalino, Kevin D. Read, Meta Roestenberg, Thomas Spangenberg, Sabine Specht, Ian H. Gilbert
Publikováno v:
ACS Infectious Diseases. 9:1046-1055
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef56205a89b9183d45c0d37e1c82e2e6
https://doi.org/10.1021/acsinfecdis.3c00081
https://doi.org/10.1021/acsinfecdis.3c00081
Autor:
Holly M Craven, Riccardo Bonsignore, Vasilis Lenis, Nicolo Santi, Daniel Berrar, Martin Swain, Helen Whiteland, Angela Casini, Karl F Hoffmann
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 2, p e0008770 (2021)
Schistosomiasis is a neglected tropical disease that currently affects over 250 million individuals worldwide. In the absence of an immunoprophylactic vaccine and the recognition that mono-chemotherapeutic control of schistosomiasis by praziquantel h
Externí odkaz:
https://doaj.org/article/9e1a5bac354f45a2b843a94e1b7f943f