Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Karl E. Miletti-González"'
CD44 promotes multi-drug resistance by protecting P-glycoprotein from FBXO21-mediated ubiquitination
Autor:
Roman P. Wernyj, Abhilash K. Ravindranath, Lorna Rodriguez-Rodriguez, Muthu N. Kumaran, Swayamjot Kaur, Elaine T. Lim, Rigel Chan, Karl E. Miletti-González, Kiran Madura
Publikováno v:
Oncotarget
Here we demonstrate that a ubiquitin E3-ligase, FBXO21, targets the multidrug resistance transporter, ABCB1, also known as P-glycoprotein (P-gp), for proteasomal degradation. We also show that the Ser291-phosphorylated form of the multifunctional pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f89377ab94c9a547c1b3d2be699720d
https://doi.org/10.18632/oncotarget.4763
https://doi.org/10.18632/oncotarget.4763
Autor:
Marina Chekmareva, Roman P. Wernyj, Kathleen W. Scotto, Muthu N. Kumaran, Gregory D. Miles, Elaine T. Lim, Karl E. Miletti-González, Michael Reiss, Kyle A. Murphy, Elisa V. Bandera, Swayamjot Kaur, Rigel Chan, Debra S. Heller, David J. Foran, Wenjin Chen, Abhilash K. Ravindranath, Lorna Rodriguez-Rodriguez
Publikováno v:
Journal of Biological Chemistry. 287:18995-19007
CD44 is a multifunctional cell receptor that conveys a cancer phenotype, regulates macrophage inflammatory gene expression and vascular gene activation in proatherogenic environments, and is also a marker of many cancer stem cells. CD44 undergoes seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d0b81d647d80eab79fb67d382d80734
https://doi.org/10.1074/jbc.m111.318774
https://doi.org/10.1074/jbc.m111.318774
Autor:
Abhilash K. Ravindranath, Lorna Rodriguez-Rodriguez, Neelakandan Muthukumaran, Karl E. Miletti-González
Publikováno v:
Molecular Cancer Research. 4:511-520
Chronic inflammation is implicated in the pathophysiology of ovarian cancer. Tumor necrosis factor-α (TNF-α), a major inflammatory cytokine, is abundant in the ovarian cancer microenvironment. TNF-α modulates the expression of CD44 in normal T lym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a12a6c3a6dfab58c9d6ae112afff62e0
https://doi.org/10.1158/1541-7786.mcr-05-0232
https://doi.org/10.1158/1541-7786.mcr-05-0232
Publikováno v:
The Journal of eukaryotic microbiology. 55(6)
Strains of the opportunistic fungal pathogen Candida albicans vary in the presence or absence of a self-splicing group I intron ribozyme (Ca.LSU) in the 25S rRNA gene on chromosome R. Strains of C. albicans typically either lack or contain this riboz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcf348bf447effb772711d598193bbb
https://pubmed.ncbi.nlm.nih.gov/19120798
https://pubmed.ncbi.nlm.nih.gov/19120798
Autor:
William N. Hait, Karl E. Miletti-González, Shiling Chen, Lorna Rodriguez-Rodriguez, Jin Ming Yang, Weichung Joe Shih, Kevin Apolito, Neelakandan Muthukumaran, Giuseppa N. Saglimbeni, Xiaohua Wu
Publikováno v:
Cancer research. 65(15)
Invasion and metastases of cancer cells and the development of resistance to anticancer therapies are the main causes of morbidity and mortality from cancer. For more than two decades, these two important but not clearly related aspects in the biolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::931a44544db93ff01e7b4ebae8c23ca7
https://pubmed.ncbi.nlm.nih.gov/16061646
https://pubmed.ncbi.nlm.nih.gov/16061646
Autor:
Christine L. Hostetter, Karl E. Miletti-González, Neelakandan Muthukumaran, Judith C. Keen, Abhilash K. Ravindranath, Lorna Rodriguez-Rodriguez
Publikováno v:
Cancer Research. 71:3078-3078
CD44, a major hyaluronic acid (HA) receptor, is involved in cell migration, metastasis and tumor progression. While in normal ovarian epithelium CD44 is not expressed, ovarian carcinoma cells express multiple CD44 isoforms as the tumor progresses and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3417dec07c50c93285220c340d7a6fe
https://doi.org/10.1158/1538-7445.am2011-3078
https://doi.org/10.1158/1538-7445.am2011-3078