Zobrazeno 1 - 10
of 86
pro vyhledávání: '"Karl E. Herbert"'
Publikováno v:
Redox Biology, Vol 14, Iss , Pp 198-210 (2018)
There is a need for robust in vitro models to sensitively capture skeletal muscle adverse toxicities early in the research and development of novel xenobiotics. To this end, an in vitro rat skeletal muscle model (L6) was used to study the translation
Externí odkaz:
https://doaj.org/article/aeccb96a1745433db51e566b4be09a39
Autor:
Nima Abbasian, Alan Bevington, James O. Burton, Karl E. Herbert, Alison H. Goodall, Nigel J. Brunskill
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 19, p 6993 (2020)
Hyperphosphataemia increases cardiovascular mortality in patients with kidney disease. Direct effects of high inorganic phosphate (Pi) concentrations have previously been demonstrated on endothelial cells (ECs), including generation of procoagulant e
Externí odkaz:
https://doaj.org/article/d96f7307206e414faf96bd0bcc105367
Publikováno v:
Redox Biology, Vol 1, Iss 1, Pp 411-417 (2013)
Mitochondria are a major source of cellular oxidants and have been implicated in aging and associated pathologies, notably cardiovascular diseases. Vascular cell senescence is observed in experimental and human cardiovascular pathologies. Our previou
Externí odkaz:
https://doaj.org/article/3fbe7ab81fad4ceb98c7ca7ecc7912a6
Autor:
Karl E. Herbert, Nima Abbasian, Alan Bevington, Nigel J. Brunskill, James O. Burton, Alison H. Goodall
Publikováno v:
International Journal of Molecular Sciences
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 6993, p 6993 (2020)
Volume 21
Issue 19
International Journal of Molecular Sciences, Vol 21, Iss 6993, p 6993 (2020)
Hyperphosphataemia increases cardiovascular mortality in patients with kidney disease. Direct effects of high inorganic phosphate (Pi) concentrations have previously been demonstrated on endothelial cells (ECs), including generation of procoagulant e
Publikováno v:
Drug Metabolism and Disposition. 46:1053-1065
Drug-induced cardiotoxicity may be modulated by endogenous arachidonic acid (AA)-derived metabolites known as epoxyeicosatrienoic acids (EETs) synthesized by cytochrome P450 2J2 (CYP2J2). The biologic effects of EETs, including their protective effec
Publikováno v:
Redox Biology, Vol 14, Iss, Pp 198-210 (2018)
Redox Biology
Redox Biology
There is a need for robust in vitro models to sensitively capture skeletal muscle adverse toxicities early in the research and development of novel xenobiotics. To this end, an in vitro rat skeletal muscle model (L6) was used to study the translation
Autor:
Karl E. Herbert, Clett Erridge
Publikováno v:
Cardiovascular Research. 114:226-232
Systemic inflammation, induced by disease or experimental intervention, is well established to result in elevated levels of circulating triglycerides, and reduced levels of high-density lipoprotein-cholesterol (HDL-C), in most mammalian species. Howe
Publikováno v:
American journal of physiology. Renal physiology. 315(5)
Extracellular vesicles (EVs), including microparticles (MPs) and exosomes (EXOs), are derived from a wide range of mammalian cells including blood platelets, endothelial cells, and kidney cells and can be detected in body fluids including blood and u
Autor:
Laurence Dawkins‐Hall, Karl E. Herbert, Meetal Satishkumar Solanki, Amy Pointon, Barry C Jones
Publikováno v:
The FASEB Journal. 32
Publikováno v:
Abstracts.
Endothelial cells play roles in regulating blood flow and in control of inflammation, both of which play important roles in atherogenesis. It is known that the NLRP3 inflammasome is involved in innate defence mechanisms in monocytes and macrophages a