Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Karl E, Zahn"'
Autor:
Monica Bubenik, Pavel Mader, Philippe Mochirian, Fréderic Vallée, Jillian Clark, Jean-François Truchon, Alexander L. Perryman, Victor Pau, Igor Kurinov, Karl E. Zahn, Marie-Eve Leclaire, Robert Papp, Marie-Claude Mathieu, Martine Hamel, Nicole M. Duffy, Claude Godbout, Matias Casas-Selves, Jean-Pierre Falgueyret, Prasamit S. Baruah, Olivier Nicolas, Rino Stocco, Hugo Poirier, Giovanni Martino, Alexanne Bonneau Fortin, Anne Roulston, Amandine Chefson, Stéphane Dorich, Miguel St-Onge, Purvish Patel, Charles Pellerin, Stéphane Ciblat, Thomas Pinter, Francis Barabé, Majida El Bakkouri, Paranjay Parikh, Christian Gervais, Agnel Sfeir, Yael Mamane, Stephen J. Morris, W. Cameron Black, Frank Sicheri, Michel Gallant
Publikováno v:
Journal of Medicinal Chemistry. 65:13198-13215
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::947c93bf7b6803db8ed4beb935e92af5
https://doi.org/10.1021/acs.jmedchem.2c00998
https://doi.org/10.1021/acs.jmedchem.2c00998
Autor:
Susan S. Wallace, Karl E. Zahn, Brittany L. Carroll, Sylvie Doublié, John P. Hanley, Julie A. Dragon
Publikováno v:
Nucleic Acids Research
Base excision repair (BER) is the main pathway protecting cells from the continuous damage to DNA inflicted by reactive oxygen species. BER is initiated by DNA glycosylases, each of which repairs a particular class of base damage. NTHL1, a bifunction
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f06ded4ede037a39b89a578b48d674d
https://doi.org/10.1093/nar/gkab1162
https://doi.org/10.1093/nar/gkab1162
Autor:
Monica, Bubenik, Pavel, Mader, Philippe, Mochirian, Fréderic, Vallée, Jillian, Clark, Jean-François, Truchon, Alexander L, Perryman, Victor, Pau, Igor, Kurinov, Karl E, Zahn, Marie-Eve, Leclaire, Robert, Papp, Marie-Claude, Mathieu, Martine, Hamel, Nicole M, Duffy, Claude, Godbout, Matias, Casas-Selves, Jean-Pierre, Falgueyret, Prasamit S, Baruah, Olivier, Nicolas, Rino, Stocco, Hugo, Poirier, Giovanni, Martino, Alexanne Bonneau, Fortin, Anne, Roulston, Amandine, Chefson, Stéphane, Dorich, Miguel, St-Onge, Purvish, Patel, Charles, Pellerin, Stéphane, Ciblat, Thomas, Pinter, Francis, Barabé, Majida, El Bakkouri, Paranjay, Parikh, Christian, Gervais, Agnel, Sfeir, Yael, Mamane, Stephen J, Morris, W Cameron, Black, Frank, Sicheri, Michel, Gallant
Publikováno v:
Journal of medicinal chemistry. 65(19)
DNA polymerase theta (Polθ) is an attractive synthetic lethal target for drug discovery, predicted to be efficacious against breast and ovarian cancers harboring BRCA-mutant alleles. Here, we describe our hit-to-lead efforts in search of a selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::531f44b082fb5f00fe6c2f82d97a48bc
https://pubmed.ncbi.nlm.nih.gov/36126059
https://pubmed.ncbi.nlm.nih.gov/36126059
Autor:
Sylvie eDoublié, Karl E Zahn
Publikováno v:
Frontiers in Microbiology, Vol 5 (2014)
Three DNA polymerases of the B family function at the replication fork in eukaryotic cells: DNA polymerases α, δ, and ε. DNA polymerase α, an heterotetramer composed of two primase subunits and two polymerase subunits, initiates replication. DNA
Externí odkaz:
https://doaj.org/article/d18ef01c93b84349bf2e92122afbd4f0
Autor:
Karl E Zahn, Ryan B. Jensen
Publikováno v:
Genes, Vol 12, Iss 1310, p 1310 (2021)
Genes
Genes
The POLQ gene encodes DNA polymerase θ, a 2590 amino acid protein product harboring DNA-dependent ATPase, template-dependent DNA polymerase, dNTP-dependent endonuclease, and 5′–dRP lyase functions. Polymerase θ participates at an essential step
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fa2ae22d0e7cf15d0f07a82bc26e7ac
https://doi.org/10.3390/genes12091310
https://doi.org/10.3390/genes12091310
Publikováno v:
Mol Cell
Cancers with hereditary defects in homologous recombination rely on DNA polymerase θ (pol θ) for repair of DNA double-strand breaks. During end-joining, pol θ aligns microhomology tracts internal to 5′-resected broken ends, after which an uniden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c0ef9550b0e158d2b23e7372477891
https://doi.org/10.1016/j.molcel.2021.01.021
https://doi.org/10.1016/j.molcel.2021.01.021
Publikováno v:
Nature Structural & Molecular Biology. 22:304-311
DNA polymerase θ protects against genomic instability via an alternative end-joining repair pathway for DNA double-strand breaks. Polymerase θ is overexpressed in breast, lung and oral cancers, and reduction of its activity in mammalian cells incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94b4378996aa0fcceb66153263979fea
https://doi.org/10.1038/nsmb.2993
https://doi.org/10.1038/nsmb.2993
Autor:
Karl E. Zahn, Roger A. Greenberg
Resection of double-strand breaks (DSBs) plays a critical role in their detection and appropriate repair. The 3' ssDNA protrusion formed through resection activates the ATR-dependent DNA damage response (DDR) and is required for DSB repair by homolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654e97ee3bc02496fee67e08c3edc4e6
https://europepmc.org/articles/PMC5287110/
https://europepmc.org/articles/PMC5287110/
Publikováno v:
Biochemistry. 50:10350-10358
5-Hydroxycytosine (5-OHC) is a stable oxidation product of cytosine associated with an increased frequency of C → T transition mutations. When this lesion escapes recognition by the base excision repair pathway and persists to serve as a templating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29cb3a4d4b48ecbbbb5297f33add7b5c
https://doi.org/10.1021/bi201219s
https://doi.org/10.1021/bi201219s
Publikováno v:
Current Opinion in Structural Biology. 21:358-369
Deducing the structure of the DNA double helix in 1953 implied the mode of its replication: Watson-Crick (WC) base pairing might instruct an enzyme, now known as the DNA polymerase, during the synthesis of a daughter stand complementary to a single s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d046b8304e6c802d6c2433e8ba52045b
https://doi.org/10.1016/j.sbi.2011.03.008
https://doi.org/10.1016/j.sbi.2011.03.008