Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Karl Dane Wittrup"'
Autor:
Guangan Hu, Yang Su, Byong Ha Kang, Zhongqi Fan, Ting Dong, Douglas R. Brown, Jaime Cheah, Karl Dane Wittrup, Jianzhu Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Macrophages may polarize into different states with distinct regulatory functions for inflammation. Here the authors perform high-throughput in vitro screening of a library of ~4000 compounds to identify those with specific effects on human macrophag
Externí odkaz:
https://doaj.org/article/1550a867bc7a4e05979cb68615b93744
Autor:
Howard L. Kaufman, Karl Dane Wittrup, Michael Schmidt, Gregory Papastoitsis, Darrell J. Irvine
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundInterleukin-12 (IL-12) is a potent pro-inflammatory cytokine that promotes Th1 skewing, IFNγ expression, T- and NK-cell activation, and antigen presentation. In animal models, IL-12 can elicit robust anti-tumor responses through activation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e514ac30409dfeec6d03b7289ce6e52
https://doaj.org/article/2ee322a227ad4b53a27f3181c4582373
https://doaj.org/article/2ee322a227ad4b53a27f3181c4582373
Autor:
Teresa Dinter, Sarah E. Blatt, Leon Yim, Ellen Duong, Karl Dane Wittrup, Tim B. Fessenden, Emi Lutz, Arjun Bhutkar, Stefani Spranger
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundConventional dendritic cells (cDC) are critical mediators of protective anti-tumor CD8+ T-cell responses.1 Batf3-driven DC1 are the predominant cDC subset driving anti-tumor immunity due to their specialized ability to cross-present antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0841f4db7bbb84d585a0964a2a0bded7
https://doaj.org/article/a6fdc843a0cb449bade1f3ba22b5ad85
https://doaj.org/article/a6fdc843a0cb449bade1f3ba22b5ad85
Autor:
Ellen, Duong, Tim B, Fessenden, Emi, Lutz, Teresa, Dinter, Leon, Yim, Sarah, Blatt, Arjun, Bhutkar, Karl Dane, Wittrup, Stefani, Spranger
Publikováno v:
Immunity. 55(2)
Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor immunity. To delineate the DC states associated with productive anti-tumor T cell immunity, we compared spontaneously regressing and progressing tumors. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::84f1b1f5eb3595bf536aeb9b01de0c88
https://pubmed.ncbi.nlm.nih.gov/34800368
https://pubmed.ncbi.nlm.nih.gov/34800368
Autor:
Jianzhu Chen, Jaime Cheah, Douglas Brown, Ting Dong, Yang Su, Karl Dane Wittrup, Guangan Hu, Byong Ha Kang, Zhongqi Fan
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Macrophages are plastic and, in response to different local stimuli, can polarize toward multi-dimensional spectrum of phenotypes, including the pro-inflammatory M1-like and the anti-inflammatory M2-like states. Using a high-throughput phenotypic scr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::977f1eaa1e7d5a39240abf8b5de5d043
http://europepmc.org/articles/PMC7858590
http://europepmc.org/articles/PMC7858590
Autor:
Karl Dane Wittrup, Sarah E. Blatt, Leon Yim, Stefani Spranger, Tim B. Fessenden, Ellen Duong, Emi Lutz, Teresa Dinter, Arjun Bhutkar
Publikováno v:
Immunity. 55:308-323.e9
Summary Tumor-infiltrating dendritic cells (DCs) assume varied functional states that impact anti-tumor immunity. To delineate the DC states associated with productive anti-tumor T cell immunity, we compared spontaneously regressing and progressing t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d655e4251ae25dc8b6237c496ea03c73
https://doi.org/10.1016/j.immuni.2021.10.020
https://doi.org/10.1016/j.immuni.2021.10.020
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A769-A769
BackgroundWhile immune checkpoint blockade therapy has improved progression-free survival in patients suffering from cancer over other treatments,1–4 these typically elicit durable responses in only minority of patients, in part because of the high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bfce558f68fdf1591f117f2585c672e
https://doi.org/10.1136/jitc-2021-sitc2021.738
https://doi.org/10.1136/jitc-2021-sitc2021.738
Autor:
Vidit Bhandarkar, Maria Zagorulya, Elen Torres-Mejia, Duncan M. Morgan, J Love, Noor Momin, Stefani Spranger, Brendan Horton, Karl Dane Wittrup
Publikováno v:
Journal for ImmunoTherapy of Cancer. 9:A326-A326
BackgroundIn non-small cell lung cancer (NSCLC), response to checkpoint blockade therapy (CBT) is associated with tumor-infiltrating CD8+ T cells, but not all T cell-infiltrated tumors respond to CBT. The subgroup of T cell-infiltrated but CBT-resist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a469adc060054ce31a030c819c027434
https://doi.org/10.1136/jitc-2021-sitc2021.303
https://doi.org/10.1136/jitc-2021-sitc2021.303
Autor:
Joshua D. Shamblin, Wen Li, Kathleen B. J. Pommert, Mark S. Klempner, Ashley E. Piper, Thomas R. Sprague, Pamela J. Glass, Arthur J. Goff, Colby A. Souders, Keith A. Reimann, Andrew B. Ward, Laura M. Walker, Karl Dane Wittrup, Erica Ollmann Saphire, Dennis R. Burton, Heidi L. Smith, Charles D. Murin, Eric Krauland, Tillman U. Gerngross, Suzanne E. Wollen, Lisa A. Cavacini, Devin Sok, Hannah L. Turner, Marnie L. Fusco, Zachary A. Bornholdt
Publikováno v:
Science. 351:1078-1083
Profiling the antibody response to Ebola The recent Ebola virus outbreak in West Africa illustrates the need not only for a vaccine but for potential therapies, too. One promising therapy is monoclonal antibodies that target Ebola's membrane-anchored
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e18b330bff1e10e41fea474bc5f592f
https://doi.org/10.1126/science.aad5788
https://doi.org/10.1126/science.aad5788
