Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Karl B. Thor"'
Publikováno v:
Continence, Vol 1, Iss , Pp 100006- (2022)
Pudendal (PUD) efferent activity contracts urethral rhabdosphincters to resist urine leakage. This study evaluates the potential for PUD nerve stimulation to provide benefit for urinary incontinence. Acute responses of the urethral rhabdosphincter to
Externí odkaz:
https://doaj.org/article/a4bcc9b1403c42e79e7c94d0324e4397
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 101:171-179
The feasibility of eliciting defecation and urination after intranasal (IN) or sublingual (SL) delivery of a small peptide NK2 receptor agonist, [Lys5, MeLeu9, Nle10]-NKA(4–10), was examined using prototype formulations in dogs. In anesthetized ani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4982a622407f86d4619cc1de523aff06
https://doi.org/10.1139/cjpp-2022-0498
https://doi.org/10.1139/cjpp-2022-0498
Autor:
Nadia M J Rupniak, Elisabetta Perdona, Cristiana Griffante, Palmina Cavallini, Anna Sava, Daniel J Ricca, Karl B Thor, Edward C Burgard, Mauro Corsi
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205894 (2018)
A series of peptide NK2 receptor agonists was evaluated for affinity, potency, efficacy, and selectivity at human recombinant NK2 and NK1 receptors expressed in CHO cells to identify compounds with the greatest separation between NK2 and NK1 receptor
Externí odkaz:
https://doaj.org/article/d70499d02d034dafa8d7da3ed632d030
Publikováno v:
Spinal Cord. 59:1013-1017
STUDY DESIGN Animal proof of principle study. OBJECTIVES Bladder and bowel dysfunction are common after spinal cord injury (SCI) and in the elderly. Neurokinin 2 receptor agonists are known to produce on-demand urination and defecation in adult SCI r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bc7f13c2f4950edd3fcd8094bd011d4d
https://doi.org/10.1038/s41393-021-00684-8
https://doi.org/10.1038/s41393-021-00684-8
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e73771 (2013)
Time- and vehicle-related variability of bladder and urethral rhabdosphincter (URS) activity as well as cardiorespiratory and blood chemistry values were examined in the acetic acid-induced bladder irritation model in α-chloralose-anesthetized femal
Externí odkaz:
https://doaj.org/article/043f60084018474b8ffecfc86caef5ca
Publikováno v:
Spinal cord. 59(9)
Animal proof of principle study.Bladder and bowel dysfunction are common after spinal cord injury (SCI) and in the elderly. Neurokinin 2 receptor agonists are known to produce on-demand urination and defecation in adult SCI rats. This study compared
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::39291553c71271aa4ee8f5ec49feca4d
https://pubmed.ncbi.nlm.nih.gov/34404911
https://pubmed.ncbi.nlm.nih.gov/34404911
Publikováno v:
J Neurotrauma
Acute administration of [Lys5,Me,Leu9,Nle10]-NKA(4-10) (LMN-NKA) produces contractions of the detrusor and rectum with voiding in intact and acutely spinal cord injured (SCI) rats. In the current study, the ability of LMN-NKA (10 μg/kg or 100 μg/kg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b624531955c535c2e072c1fa03c76f84
https://europepmc.org/articles/PMC7071061/
https://europepmc.org/articles/PMC7071061/
Autor:
Karl B. Thor, Jiayang Sun, Anita Kaiser, Abby Bolon, Jennifer French, Dennis Bourbeau, Tara Jeji, Roman Kouznetsov, Bill Fertig, Jane Wierbicky, Wei Dai, Graham H. Creasey, Bruno Gallo Santacruz, Alexander G. Rabchevsky, Tracey Wheeler
Publikováno v:
Spinal cord
Study Design: Survey. Objectives: To investigate the needs and priorities of people with spinal cord injury for managing neurogenic bladder and bowel function and to determine their willingness to adopt neuromodulation interventions for these functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2becae0bf000bea7af88d05d2c3548
https://pubmed.ncbi.nlm.nih.gov/32895475
https://pubmed.ncbi.nlm.nih.gov/32895475
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 391:907-914
The effects of the tachykinin NK2 receptor agonist LMN-NKA ([Lys5,MeLeu9,Nle10]-NKA(4-10)) on colorectal and arterial blood pressure were examined in anesthetized macaques. Intravenous (IV) administration of 1–100 μg/kg caused dose-related increas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7236e2cf8f0393b7f5ca84d2e699fb80
https://doi.org/10.1007/s00210-018-1520-6
https://doi.org/10.1007/s00210-018-1520-6
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 366:136-144
Tachykinin neurokinin 2 (NK2) receptor agonists may have potential to alleviate clinical conditions associated with bladder and gastrointestinal underactivity by stimulating contraction of visceral smooth muscle. The ability of [Lys5,MeLeu9,Nle10]-ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a5939a6f239c83cb851441f1fff86245
https://doi.org/10.1124/jpet.118.248765
https://doi.org/10.1124/jpet.118.248765