Zobrazeno 1 - 10
of 600
pro vyhledávání: '"Karl A. Lang"'
Autor:
Paul M. Betka, Stuart N. Thomson, Ryan Sincavage, C. Zoramthara, C. Lalremruatfela, Karl A. Lang, Michael S. Steckler, Devojit Bezbaruah, Pradip Borgohain, Leonardo Seeber
Publikováno v:
Geochemistry, Geophysics, Geosystems, Vol 22, Iss 12, Pp n/a-n/a (2021)
Abstract The Bengal Basin preserves the erosional signals of coupled tectonic‐climatic change during late Cenozoic development of the Himalayan orogen, yet regional correlation and interpretation of these signals remains incomplete. We present a ne
Externí odkaz:
https://doaj.org/article/e1fe7355be30463b8a8aa05848105b70
Publikováno v:
Financial Innovation, Vol 8, Iss 1, Pp 1-4 (2022)
Externí odkaz:
https://doaj.org/article/d92e5aed40954fe4b79734f45b38c0c3
Autor:
Haifeng C. Xu, Jun Huang, Aleksandra A. Pandyra, Piyush Pandey, Ruifeng Wang, Zeli Zhang, Yuan Zhuang, Christoph G.W. Gertzen, Carsten Münk, Diran Herebian, Arndt Borkhardt, Mike Recher, Holger Gohlke, Irene Esposito, Martin Oberbarnscheidt, Dieter Häussinger, Karl S. Lang, Philipp A. Lang
Publikováno v:
Hepatology Communications, Vol 6, Iss 7, Pp 1620-1633 (2022)
Major histocompatibility complex I (MHC‐I) molecules present epitopes on the cellular surface of antigen‐presenting cells to prime cytotoxic clusters of differentiation 8 (CD8)+ T cells (CTLs), which then identify and eliminate other cells such a
Externí odkaz:
https://doaj.org/article/162c721aae254ca7b08f8550afa6f30a
Autor:
Phyllis F. Cheung, JiaJin Yang, Rui Fang, Arianna Borgers, Kirsten Krengel, Anne Stoffel, Kristina Althoff, Chi Wai Yip, Elaine H. L. Siu, Linda W. C. Ng, Karl S. Lang, Lamin B. Cham, Daniel R. Engel, Camille Soun, Igor Cima, Björn Scheffler, Jana K. Striefler, Marianne Sinn, Marcus Bahra, Uwe Pelzer, Helmut Oettle, Peter Markus, Esther M. M. Smeets, Erik H. J. G. Aarntzen, Konstantinos Savvatakis, Sven-Thorsten Liffers, Smiths S. Lueong, Christian Neander, Anna Bazarna, Xin Zhang, Annette Paschen, Howard C. Crawford, Anthony W. H. Chan, Siu Tim Cheung, Jens T. Siveke
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Immune responses to pancreatic ductal adenocarcinoma can be inhibited by cancer cells. Here the authors show that high levels of progranulin in PDAC inhibits immune responses by reducing MHC class I antigen presentation through enhanced degradation o
Externí odkaz:
https://doaj.org/article/c9aa189db2194c2eba13f30f461a6fdd
Autor:
Philip Podschwadt, Anna Malyshkina, Sonja Windmann, Athanasios Papadamakis, Leonie Kerkmann, Dennis Lapuente, Matthias Tenbusch, Mengji Lu, Michael Schindler, Karl Sebastian Lang, Wiebke Hansen, Wibke Bayer
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Retroviral envelope (Env) proteins have long been recognized to exhibit immunosuppressive properties, which affect the CD8+ T-cell response to an infection but also to immunization. Interestingly, we previously showed in the Friend murine leukemia vi
Externí odkaz:
https://doaj.org/article/f61df26f123f489f9237b43dcb2f1058
Autor:
Anne Günther, Matthias Hose, Hanna Abberger, Fabian Schumacher, Ylva Veith, Burkhard Kleuser, Kai Matuschewski, Karl Sebastian Lang, Erich Gulbins, Jan Buer, Astrid M Westendorf, Wiebke Hansen
Publikováno v:
eLife, Vol 11 (2022)
Acid ceramidase (Ac) is part of the sphingolipid metabolism and responsible for the degradation of ceramide. As bioactive molecule, ceramide is involved in the regulation of many cellular processes. However, the impact of cell-intrinsic Ac activity a
Externí odkaz:
https://doaj.org/article/d7bfdd0ec15f450d8112fb8ebc0a7fda
Autor:
Haifeng C. Xu, Ruifeng Wang, Prashant V. Shinde, Lara Walotka, Anfei Huang, Gereon Poschmann, Jun Huang, Wei Liu, Kai Stühler, Heiner Schaal, Andreas Bergthaler, Aleksandra A. Pandyra, Cornelia Hardt, Karl S. Lang, Philipp A. Lang
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Using different strains of the lymphocytic choriomeningitis virus (LCMV), Xu, Wang et al. show that a slow viral propagation limits type I interferon (IFN-I) production and viral persistence in mice. This study suggests a reduced viral propagation as
Externí odkaz:
https://doaj.org/article/e64f13b539b04accba130bd3d10b5844
Autor:
Julia Zöller, Jana-Fabienne Ebel, Vishal Khairnar, Verena Schmitt, Robert Klopfleisch, Jana Meiners, Virginia Seiffart, Wiebke Hansen, Jan Buer, Bernhard B. Singer, Karl S. Lang, Astrid M. Westendorf
Publikováno v:
Gut Microbes, Vol 11, Iss 6, Pp 1790-1805 (2020)
The incidence of gastrointestinal infections continues to increase, and infectious colitis contributes significantly to morbidity and mortality worldwide. Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) has been discovered to be s
Externí odkaz:
https://doaj.org/article/ff034aef2bb14218ab6925a441b6330f
Autor:
Judith Lang, Patrick Bohn, Hilal Bhat, Holger Jastrow, Bernd Walkenfort, Feyza Cansiz, Julian Fink, Michael Bauer, Dominik Olszewski, Ana Ramos-Nascimento, Vikas Duhan, Sarah-Kim Friedrich, Katrin Anne Becker, Adalbert Krawczyk, Michael J. Edwards, Andreas Burchert, Magdalena Huber, Justa Friebus-Kardash, Joachim R. Göthert, Cornelia Hardt, Hans Christian Probst, Fabian Schumacher, Karl Köhrer, Burkhard Kleuser, Eduard B. Babiychuk, Beate Sodeik, Jürgen Seibel, Urs F. Greber, Philipp A. Lang, Erich Gulbins, Karl S. Lang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Macrophages are critical in limiting replication of herpes simplex virus type 1 (HSV-1). Here the authors show how acid ceramidase and its enzymatic product sphingosine enable multivesicular bodies to function as an anti-viral mechanism.
Externí odkaz:
https://doaj.org/article/ce87beeac86246829e4b47c4ed971f39
Autor:
Wei Liu, Paweł Stachura, Haifeng C. Xu, Nikkitha Umesh Ganesh, Fiona Cox, Ruifeng Wang, Karl S. Lang, Jay Gopalakrishnan, Dieter Häussinger, Bernhard Homey, Philipp A. Lang, Aleksandra A. Pandyra
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 39, Iss 1, Pp 1-16 (2020)
Abstract Background New therapies are urgently needed in melanoma particularly in late-stage patients not responsive to immunotherapies and kinase inhibitors. Methods Drug screening, IC50 determinations as well as synergy assays were detected by the
Externí odkaz:
https://doaj.org/article/4e58bc7a3f57475c980c5ecf84365c51